WO2008096732A1 - Microneedle device for diagnosis of allergy - Google Patents

Microneedle device for diagnosis of allergy Download PDF

Info

Publication number
WO2008096732A1
WO2008096732A1 PCT/JP2008/051825 JP2008051825W WO2008096732A1 WO 2008096732 A1 WO2008096732 A1 WO 2008096732A1 JP 2008051825 W JP2008051825 W JP 2008051825W WO 2008096732 A1 WO2008096732 A1 WO 2008096732A1
Authority
WO
WIPO (PCT)
Prior art keywords
allergy
diagnosis
microneedle device
microneedles
microneedle
Prior art date
Application number
PCT/JP2008/051825
Other languages
French (fr)
Japanese (ja)
Inventor
Seiji Tokumoto
Toshiyuki Matsudo
Tetsuji Kuwahara
Original Assignee
Hisamitsu Pharmaceutical Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co., Inc. filed Critical Hisamitsu Pharmaceutical Co., Inc.
Priority to US12/525,818 priority Critical patent/US20100030100A1/en
Priority to JP2008557112A priority patent/JP5241517B2/en
Priority to EP08704452.5A priority patent/EP2119469B1/en
Priority to ES08704452.5T priority patent/ES2473620T3/en
Publication of WO2008096732A1 publication Critical patent/WO2008096732A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0035—Vaccination diagnosis other than by injuring the skin, e.g. allergy test patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Surgical Instruments (AREA)

Abstract

Disclosed is an inexpensive microneedle device for use in the diagnosis of an allergy, which can achieve clear determination on the skin in an allergy diagnosis within a short period by a simple operation. The microneedle device (1) comprises: a microneedle substrate (2); microneedles (3) which are provided on the substrate at a density of 100 to 10000 pieces per 1 cm2, can puncture the skin, and has a length of 50 to 500 μm; and an antigen-holding means (4) which is provided on each of the microneedles and can hold at least one allergy antigen thereon. The microneedles (3) can be produced using a non-metallic, synthetic or natural resin material.
PCT/JP2008/051825 2007-02-06 2008-02-05 Microneedle device for diagnosis of allergy WO2008096732A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/525,818 US20100030100A1 (en) 2007-02-06 2008-02-05 Microneedle Device For Diagnosis Of Allergy
JP2008557112A JP5241517B2 (en) 2007-02-06 2008-02-05 Microneedle device for allergy diagnosis
EP08704452.5A EP2119469B1 (en) 2007-02-06 2008-02-05 Microneedle device for diagnosis of allergy
ES08704452.5T ES2473620T3 (en) 2007-02-06 2008-02-05 Microneedle device for the diagnosis of an allergy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007026650 2007-02-06
JP2007-026650 2007-02-06

Publications (1)

Publication Number Publication Date
WO2008096732A1 true WO2008096732A1 (en) 2008-08-14

Family

ID=39681641

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/051825 WO2008096732A1 (en) 2007-02-06 2008-02-05 Microneedle device for diagnosis of allergy

Country Status (5)

Country Link
US (1) US20100030100A1 (en)
EP (1) EP2119469B1 (en)
JP (1) JP5241517B2 (en)
ES (1) ES2473620T3 (en)
WO (1) WO2008096732A1 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010069252A (en) * 2008-09-22 2010-04-02 Fujifilm Corp Method for manufacturing transdermal absorption sheet
JP2010082401A (en) * 2008-09-29 2010-04-15 Kosumedei Seiyaku Kk Microneedle array
WO2010040271A1 (en) * 2008-10-07 2010-04-15 Tuo Jin Phase-transition polymeric microneedles
WO2010143689A1 (en) * 2009-06-10 2010-12-16 久光製薬株式会社 Microneedle device
JP2013162861A (en) * 2012-02-10 2013-08-22 Bioserentack Co Ltd Microneedle for monitoring intercellular fluid
US8696638B2 (en) 2009-07-23 2014-04-15 Hisamitsu Pharmaceutical Co., Inc. Microneedle array
JP5709530B2 (en) * 2009-01-30 2015-04-30 久光製薬株式会社 Microneedle device
JP2019528108A (en) * 2016-08-12 2019-10-10 プロラゲン カンパニー リミテッド Microneedle patch, method for producing the same, and method for operating the same for diagnosis of allergic diseases
KR102122208B1 (en) * 2020-04-07 2020-06-12 주식회사 라파스 Minimally invasive method for evaluating activity of atopic dermatitis using microneedle patch and minimally invasive atopic dermatitis activity evaluating kit including microneedle patch

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010074239A1 (en) * 2008-12-26 2010-07-01 久光製薬株式会社 Microneedle device
EP2540337B1 (en) * 2010-02-24 2019-04-03 Hisamitsu Pharmaceutical Co., Inc. Micro-needle device and preparation method
JPWO2011105496A1 (en) 2010-02-24 2013-06-20 久光製薬株式会社 Microneedle device
EP3225247B1 (en) * 2010-05-28 2020-09-02 3M Innovative Properties Company Aqueous formulations for coating microneedle arrays
US10244981B2 (en) * 2011-03-30 2019-04-02 SensiVida Medical Technologies, Inc. Skin test image analysis apparatuses and methods thereof
MX2013012349A (en) * 2011-04-22 2014-07-09 Radius Health Inc Method of drug delivery for pth, pthrp and related peptides.
GB2492361A (en) * 2011-06-29 2013-01-02 Hds Ltd Micropatch for contact allergy testing
WO2013001007A1 (en) * 2011-06-29 2013-01-03 Hds Limited An improved micropatch for assessing chemical contact allergy
GB201116143D0 (en) * 2011-09-16 2011-11-02 Univ Greenwich Method of coating microneedle devices
JP6265740B2 (en) 2011-10-06 2018-01-24 久光製薬株式会社 applicator
US8469900B2 (en) * 2011-11-30 2013-06-25 Lincoln Diagnostics, Inc. Allergy testing device and method of testing for allergies
US9011350B2 (en) 2011-11-30 2015-04-21 Lincoln Diagnostics, Inc. Allergy testing device and method of testing for allergies
KR102378235B1 (en) 2012-12-14 2022-03-25 민데라 코포레이션 Methods and devices for detection and acquisition of biomarkers
EP2995342B1 (en) * 2013-05-06 2019-06-26 Juvic Inc. Method for manufacturing microstructure using centrifugal force and microstructure manufactured by same
US10426403B2 (en) 2013-05-08 2019-10-01 The Board Of Trustees Of The Leland Stanford Junior University Methods of testing for allergen sensitivity
JP7019422B2 (en) 2015-04-29 2022-02-15 ラジウス ファーマシューティカルズ，インコーポレイテッド How to treat cancer
CN105078880A (en) * 2015-09-12 2015-11-25 北京化工大学 Macromolecular soluble microneedle used for cutaneous penetration of polypeptide and protein medicines and preparation method of macromolecular soluble microneedle
CN117417263A (en) 2017-01-05 2024-01-19 雷迪厄斯制药公司 Polymorphic forms of RAD1901-2HCL
KR20210030393A (en) 2018-07-04 2021-03-17 래디어스 파마슈티컬스, 인코포레이티드 Polymorphic form of RAD1901-2HCL
US20230148946A1 (en) * 2020-03-27 2023-05-18 Aquavit Pharmaceuticals, Inc. Methods of detecting allergic reactions in subjects using microchannel delivery devices
US11931537B2 (en) 2020-10-05 2024-03-19 SensiVida Medical Technologies Inc. Practice-loadable minimally invasive allergy test system

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58131919A (en) 1981-12-14 1983-08-06 ニコラス・エツチ・マガニアス Allergy test and test strip
JP2506543B2 (en) 1992-01-22 1996-06-12 ベクトン・ディッキンソン・アンド・カンパニー Molecules for delivery by iontophoresis
JP2002535100A (en) 1999-01-28 2002-10-22 サイト パルス サイエンシズ、インコーポレイテッド Delivery of macromolecules into cells
JP2004028900A (en) * 2002-06-27 2004-01-29 Japan Science & Technology Corp Infrared beam condensing device
JP2004528900A (en) 2001-04-20 2004-09-24 アルザ・コーポレーシヨン Microprojection array with coating containing beneficial agent

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713291B2 (en) * 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
WO2002064193A2 (en) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
ATE420676T1 (en) * 2001-10-29 2009-01-15 Becton Dickinson Co DEVICE FOR DELIVERING A SUBSTANCE
AU2002360648B2 (en) * 2001-12-14 2009-01-08 Genetronics, Inc. Methods for particle-assisted polynucleotide immunization using a pulsed electric field
US20050226822A1 (en) * 2002-04-25 2005-10-13 Gaba International Ag Oral care products containing ovomucin
US7591806B2 (en) * 2004-05-18 2009-09-22 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
JP5139301B2 (en) * 2005-09-21 2013-02-06 サーモディクス，インコーポレイティド Coatings and devices containing biodegradable natural polysaccharides

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58131919A (en) 1981-12-14 1983-08-06 ニコラス・エツチ・マガニアス Allergy test and test strip
JP2506543B2 (en) 1992-01-22 1996-06-12 ベクトン・ディッキンソン・アンド・カンパニー Molecules for delivery by iontophoresis
JP2002535100A (en) 1999-01-28 2002-10-22 サイト パルス サイエンシズ、インコーポレイテッド Delivery of macromolecules into cells
JP2004528900A (en) 2001-04-20 2004-09-24 アルザ・コーポレーシヨン Microprojection array with coating containing beneficial agent
JP2004028900A (en) * 2002-06-27 2004-01-29 Japan Science & Technology Corp Infrared beam condensing device

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010069252A (en) * 2008-09-22 2010-04-02 Fujifilm Corp Method for manufacturing transdermal absorption sheet
JP2010082401A (en) * 2008-09-29 2010-04-15 Kosumedei Seiyaku Kk Microneedle array
WO2010040271A1 (en) * 2008-10-07 2010-04-15 Tuo Jin Phase-transition polymeric microneedles
US9320878B2 (en) 2008-10-07 2016-04-26 Tuo Jin Phase-transition polymeric microneedles
JP2012505164A (en) * 2008-10-07 2012-03-01 ジン・トゥオ Phase change polymer microneedle
JP5709530B2 (en) * 2009-01-30 2015-04-30 久光製薬株式会社 Microneedle device
EP2441437A4 (en) * 2009-06-10 2013-05-01 Hisamitsu Pharmaceutical Co Microneedle device
JPWO2010143689A1 (en) * 2009-06-10 2012-11-29 久光製薬株式会社 Microneedle device
CN102458359A (en) * 2009-06-10 2012-05-16 久光制药株式会社 Microneedle device
US8747362B2 (en) 2009-06-10 2014-06-10 Hisamitsu Pharmaceutical Co., Inc Microneedle device
JP5615814B2 (en) * 2009-06-10 2014-10-29 久光製薬株式会社 Microneedle device
EP2441437A1 (en) * 2009-06-10 2012-04-18 Hisamitsu Pharmaceutical Co., Inc. Microneedle device
WO2010143689A1 (en) * 2009-06-10 2010-12-16 久光製薬株式会社 Microneedle device
US8696638B2 (en) 2009-07-23 2014-04-15 Hisamitsu Pharmaceutical Co., Inc. Microneedle array
JP2013162861A (en) * 2012-02-10 2013-08-22 Bioserentack Co Ltd Microneedle for monitoring intercellular fluid
JP2019528108A (en) * 2016-08-12 2019-10-10 プロラゲン カンパニー リミテッド Microneedle patch, method for producing the same, and method for operating the same for diagnosis of allergic diseases
KR102122208B1 (en) * 2020-04-07 2020-06-12 주식회사 라파스 Minimally invasive method for evaluating activity of atopic dermatitis using microneedle patch and minimally invasive atopic dermatitis activity evaluating kit including microneedle patch
WO2021206218A1 (en) * 2020-04-07 2021-10-14 주식회사 라파스 Miminally-invasive atopic dermatitis test method using microneedle patch and minimally-invasive atopic dermatitis test kit comprising microneedle patch
JP7479726B2 (en) 2020-04-07 2024-05-09 ラパス カンパニー リミテッド Minimally invasive atopic dermatitis testing method using a microneedle patch, and a minimally invasive atopic dermatitis testing kit including a microneedle patch

Also Published As

Publication number Publication date
US20100030100A1 (en) 2010-02-04
JP5241517B2 (en) 2013-07-17
EP2119469A4 (en) 2011-06-22
EP2119469A1 (en) 2009-11-18
ES2473620T3 (en) 2014-07-07
JPWO2008096732A1 (en) 2010-05-20
EP2119469B1 (en) 2014-05-14

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