WO2008096373A3 - Process for synthesizing highly pure nateglinide polymorphs - Google Patents

Process for synthesizing highly pure nateglinide polymorphs Download PDF

Info

Publication number
WO2008096373A3
WO2008096373A3 PCT/IN2008/000073 IN2008000073W WO2008096373A3 WO 2008096373 A3 WO2008096373 A3 WO 2008096373A3 IN 2008000073 W IN2008000073 W IN 2008000073W WO 2008096373 A3 WO2008096373 A3 WO 2008096373A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymorphs
highly pure
nateglinide
synthesizing highly
pure nateglinide
Prior art date
Application number
PCT/IN2008/000073
Other languages
French (fr)
Other versions
WO2008096373A2 (en
Inventor
Chidambaram Venkateswaran Srinivasan
Gurdeep Singh Sarin
Lalit Wadhwa
Original Assignee
Ind-Swift Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind-Swift Laboratories Limited filed Critical Ind-Swift Laboratories Limited
Publication of WO2008096373A2 publication Critical patent/WO2008096373A2/en
Publication of WO2008096373A3 publication Critical patent/WO2008096373A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives

Abstract

The present invention relates to an improved process for synthesizing highly pure nateglinide of formula-(I). More particularly, the present invention relates to the process for synthesizing highly enantiomerically pure nateglinide form B and form H directly from nateglinide alkyl ester.
PCT/IN2008/000073 2007-02-06 2008-02-06 Process for synthesizing highly pure nateglinide polymorphs WO2008096373A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IN232/DEL/2007 2007-02-06
IN232DE2007 2007-02-06
IN2403/DEL/2007 2007-11-14
IN2403DE2007 2007-11-14
IN215/DEL/2008 2008-01-25
IN215DE2008 2008-01-25

Publications (2)

Publication Number Publication Date
WO2008096373A2 WO2008096373A2 (en) 2008-08-14
WO2008096373A3 true WO2008096373A3 (en) 2010-04-29

Family

ID=39682194

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000073 WO2008096373A2 (en) 2007-02-06 2008-02-06 Process for synthesizing highly pure nateglinide polymorphs

Country Status (1)

Country Link
WO (1) WO2008096373A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227073B1 (en) 2003-07-10 2010-06-28 Richter Gedeon Nyrt Process for the preparation of chirally pure n-(trans-4-isopropyl-cyclohexylcarbonyl)-d-phenyl-alanine (nateglinide) and it's crystalline forms and the cristalline form g
WO2010106550A2 (en) * 2009-03-09 2010-09-23 Neuland Laboratories Ltd. A process for the preparation of n-[[trans-4-(1-methylethyl)cyclohexyl]carbonyl]-d-phenylalanine
WO2011157986A1 (en) 2010-06-14 2011-12-22 Cipla Limited A process for the preparation of nateglinide
CN109369443A (en) * 2018-11-05 2019-02-22 扬子江药业集团江苏海慈生物药业有限公司 A kind of preparation method of new Nateglinide H crystal form

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060148902A1 (en) * 2005-01-03 2006-07-06 Enrico Vigano' Process for the preparation of nateglinide, preferably in B-form

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060148902A1 (en) * 2005-01-03 2006-07-06 Enrico Vigano' Process for the preparation of nateglinide, preferably in B-form

Also Published As

Publication number Publication date
WO2008096373A2 (en) 2008-08-14

Similar Documents

Publication Publication Date Title
WO2007106690A3 (en) Degenerate nucleobase analogs
WO2008151170A3 (en) Process for the synthesis of ramelteon and its intermediates
WO2011139702A3 (en) Modified nucleosides and oligomeric compounds prepared therefrom
MX2010003599A (en) Intermediates and methods for the synthesis of halichondrin b analogs.
WO2010102980A9 (en) Process for preparing substituted 2-nitrobiphenyls
WO2010048477A3 (en) Improved process for preparation of coupled products from 4-amino-3-cyanoquinolines using stabilized intermediates
IL213060A0 (en) Polymorphs of (s)-3-aminomethyl-7-(3-hydroxy-propoxy)-3h-benzo[c][1,2]oxaborol-1-ol
EP2344443A4 (en) Method of preparing of 60% or more cis-di(c4-c20)alkyl cyclohexane-1,4-dicarboxylate
WO2012015681A3 (en) Drug-ligand conjugates, synthesis thereof, and intermediates thereto
WO2010028122A8 (en) Process for making bivalirudin
IL192231A0 (en) An improved process for the preparation of armodafinil
WO2008053334A3 (en) An improved process for preparing rosuvastatin calcium
WO2011024192A3 (en) Novel polymorphs of raltegravir
WO2009053446A3 (en) Pregabalin intermediates and process for preparing them and pregabalin
WO2007132354A3 (en) Process for preparing voriconazole, new polymorphic form of intermediate thereof, and uses thereof
WO2008075205A3 (en) Improved process for the preparation of voriconazole
WO2010065586A3 (en) Preparation of capecitabine
WO2010004578A3 (en) Novel and improved processes for the preparation of paliperidone
WO2013076743A3 (en) Process for the purification of polyaminocarboxylates
WO2010015656A3 (en) Alkoxypyrazoles and the process for their preparation
WO2008096373A3 (en) Process for synthesizing highly pure nateglinide polymorphs
WO2009116081A3 (en) An improved process for the preparation of aprepitant
WO2009062659A3 (en) Polymorphs of enantiopure erdosteine
WO2006122020A3 (en) Process for production of 4-biphenylyazetidin-2-ones
WO2010059916A3 (en) Preparation of docetaxel

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08710276

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08710276

Country of ref document: EP

Kind code of ref document: A2