WO2008087917A1 - 視細胞への分化誘導方法 - Google Patents

視細胞への分化誘導方法 Download PDF

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Publication number
WO2008087917A1
WO2008087917A1 PCT/JP2008/050305 JP2008050305W WO2008087917A1 WO 2008087917 A1 WO2008087917 A1 WO 2008087917A1 JP 2008050305 W JP2008050305 W JP 2008050305W WO 2008087917 A1 WO2008087917 A1 WO 2008087917A1
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progenitor cell
retinal progenitor
culture
cell
differentiation
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PCT/JP2008/050305
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English (en)
French (fr)
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Masayo Takahashi
Fumitaka Osakada
Michiko Mandai
Hanako Ikeda
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Riken
Kyoto University
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Priority to US12/523,444 priority Critical patent/US9133435B2/en
Priority to EP08703169A priority patent/EP2128244A4/en
Priority to JP2008554025A priority patent/JP5441099B2/ja
Publication of WO2008087917A1 publication Critical patent/WO2008087917A1/ja

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Abstract

　本発明は、無血清培地中で霊長類の胚性幹細胞を浮遊凝集体として培養すること、及び培養物から網膜前駆細胞を得ることを含む、霊長類の網膜前駆細胞の製造方法を提供する。本発明は更に、胚性幹細胞から分化誘導された、単離された網膜前駆細胞を、接着条件下、ガンマセクレターゼ阻害剤の存在下で培養すること、及び培養物から視細胞前駆体を得ることを含む、視細胞前駆体の製造方法を提供する。
PCT/JP2008/050305 2007-01-18 2008-01-11 視細胞への分化誘導方法 WO2008087917A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/523,444 US9133435B2 (en) 2007-01-18 2008-01-11 Method for induction/differentiation into photoreceptor cell
EP08703169A EP2128244A4 (en) 2007-01-18 2008-01-11 INDUCTION / DIFFERENTIATION METHOD IN PHOTORECEPTOR CELL
JP2008554025A JP5441099B2 (ja) 2007-01-18 2008-01-11 視細胞への分化誘導方法

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JP2007-009617 2007-01-18
JP2007009617 2007-01-18

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WO2008087917A1 true WO2008087917A1 (ja) 2008-07-24

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EP (1) EP2128244A4 (ja)
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WO (1) WO2008087917A1 (ja)

Cited By (24)

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WO2011055855A1 (en) * 2009-11-05 2011-05-12 Riken A method for differentiation induction in cultured stem cells
JP2012511935A (ja) * 2008-12-17 2012-05-31 ザ スクリプス リサーチ インスティチュート 幹細胞の作製と維持
JP2013502234A (ja) * 2009-08-24 2013-01-24 ウイスコンシン アラムナイ リサーチ ファウンデーシヨン 実質的に純粋なヒト網膜前駆細胞培養物、前脳前駆細胞培養物、網膜色素上皮細胞培養物、及び、それらの製造方法
WO2013077425A1 (ja) 2011-11-25 2013-05-30 住友化学株式会社 網膜組織及び網膜関連細胞の製造方法
JP2013128476A (ja) * 2011-11-25 2013-07-04 Sumitomo Chemical Co Ltd 眼杯様構造体の製造方法
JP2013128474A (ja) * 2011-11-25 2013-07-04 Sumitomo Chemical Co Ltd 網膜色素上皮細胞の製造方法
JP2013128477A (ja) * 2011-11-25 2013-07-04 Sumitomo Chemical Co Ltd 網膜層特異的神経細胞を製造する方法
JP2013128475A (ja) * 2011-11-25 2013-07-04 Sumitomo Chemical Co Ltd 網膜組織の製造方法
JP2013530699A (ja) * 2010-06-15 2013-08-01 セルラー ダイナミクス インターナショナル， インコーポレイテッド 生物学的応答の調査のための既製の幹細胞モデルの概要
WO2015087231A1 (en) 2013-12-11 2015-06-18 Pfizer Limited Method for producing retinal pigment epithelial cells
US9133435B2 (en) 2007-01-18 2015-09-15 Riken Method for induction/differentiation into photoreceptor cell
JP2016515382A (ja) * 2013-03-15 2016-05-30 オカタ セラピューティクス， インコーポレイテッド 多能性幹細胞から生成された光受容体および光受容体前駆体
JP2016537967A (ja) * 2013-10-09 2016-12-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 哺乳動物の網膜幹細胞の生産方法及び適用
JP2018526032A (ja) * 2015-09-08 2018-09-13 フジフィルム セルラー ダイナミクス，インコーポレイテッド Ｍａｃｓを用いた幹細胞由来網膜色素上皮の精製
KR20180135482A (ko) * 2016-04-22 2018-12-20 다이닛본 스미토모 세이야꾸 가부시끼가이샤 망막 조직의 제조 방법
US10227563B2 (en) 2008-06-06 2019-03-12 Riken Method for culture of stem cell
JPWO2018074567A1 (ja) * 2016-10-21 2019-08-08 国立大学法人群馬大学 末梢神経細胞の製造方法
KR20190123266A (ko) * 2017-02-17 2019-10-31 쏘흐본느 유니베흐시테 망막 전구 세포, 망막 색소 상피 세포 및 신경 망막 세포를 얻기 위한 피더-비의존적(Feeder-free) 방법
US10519422B2 (en) 2012-02-29 2019-12-31 Riken Method of producing human retinal pigment epithelial cells
US11241460B2 (en) 2013-03-15 2022-02-08 Astellas Institute For Regenerative Medicine Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
US11618883B2 (en) 2017-03-08 2023-04-04 Sumitomo Pharma Co., Ltd. Method for producing retinal pigment epithelial cells
US11649432B2 (en) 2015-09-08 2023-05-16 Sumitomo Pharma Co., Ltd. Method for producing retinal pigment epithelial cells
WO2023149565A1 (ja) * 2022-02-07 2023-08-10 国立大学法人大阪大学 多能性幹細胞から網膜色素上皮細胞への分化誘導方法
WO2024004960A1 (ja) * 2022-06-27 2024-01-04 武田薬品工業株式会社 細胞の培養方法

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WO2012013936A1 (en) * 2010-07-30 2012-02-02 Cambridge Enterprise Limited Corticogenesis of human pluripotent cells
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EP2951290B1 (en) 2013-02-01 2017-11-29 The United States of America, as represented by The Secretary, Department of Health and Human Services Method for generating retinal pigment epithelium (rpe) cells from induced pluripotent stem cells (ipscs)
JP6580989B2 (ja) 2013-08-23 2019-09-25 住友化学株式会社 網膜組織及び網膜関連細胞の製造方法
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WO2015109148A1 (en) 2014-01-16 2015-07-23 The Johns Hopkins University Methods for forming three-dimensional human retinal tissue in vitro
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JP6976939B2 (ja) 2015-10-20 2021-12-08 フジフィルム セルラー ダイナミクス，インコーポレイテッド 遺伝的プログラミングによる多系統造血前駆細胞の作製
JP6987769B2 (ja) 2015-10-26 2022-01-05 セル キュア ニューロサイエンシズ リミテッド 網膜色素上皮細胞の調製法
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CA3086815A1 (en) 2017-12-29 2019-07-04 Cell Cure Neurosciences Ltd. Retinal pigment epithelium cell compositions
CN113038951B (zh) 2018-09-20 2024-04-30 耶达研究及发展有限公司 治疗肌萎缩侧索硬化的方法
EP3754014A1 (en) 2019-06-21 2020-12-23 Centre d'Etude des Cellules Souches (CECS) Automated method for preparing retinal pigment epithelium cells
EP4237084A1 (en) * 2020-11-01 2023-09-06 The Johns Hopkins University Compositions and methods for cellular component transfer therapy
CN113073136A (zh) * 2021-03-31 2021-07-06 中国科学技术大学 感光细胞退化作为阿尔茨海默病诊断靶点的应用
KR102525093B1 (ko) * 2021-04-16 2023-04-27 가톨릭대학교 산학협력단 사람 신경능 유래 코 하비갑개 줄기세포를 유효성분으로 포함하는 망막변성질환 예방 또는 치료용 약학적 조성물
WO2022261320A1 (en) 2021-06-09 2022-12-15 Lineage Cell Therapeutics, Inc. Methods and compositions for treating retinal diseases and conditions
KR20240038013A (ko) 2021-07-28 2024-03-22 리니지 셀 테라퓨틱스, 인크. 망막 색소 상피 세포의 확장
WO2023211857A1 (en) 2022-04-25 2023-11-02 Lineage Cell Therapeutics, Inc. Methods and compositions for treating vision loss

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