WO2008079705A3 - Acyl-transferase - Google Patents

Acyl-transferase Download PDF

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Publication number
WO2008079705A3
WO2008079705A3 PCT/US2007/087334 US2007087334W WO2008079705A3 WO 2008079705 A3 WO2008079705 A3 WO 2008079705A3 US 2007087334 W US2007087334 W US 2007087334W WO 2008079705 A3 WO2008079705 A3 WO 2008079705A3
Authority
WO
WIPO (PCT)
Prior art keywords
transferase
acyl
hgoat
directed
present
Prior art date
Application number
PCT/US2007/087334
Other languages
French (fr)
Other versions
WO2008079705A2 (en
Inventor
Jesus Antonio Gutierrez
Douglas Raymond Perkins
Patricia Jean Solenberg
Original Assignee
Lilly Co Eli
Jesus Antonio Gutierrez
Douglas Raymond Perkins
Patricia Jean Solenberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Jesus Antonio Gutierrez, Douglas Raymond Perkins, Patricia Jean Solenberg filed Critical Lilly Co Eli
Priority to EP07855109A priority Critical patent/EP2102232A2/en
Publication of WO2008079705A2 publication Critical patent/WO2008079705A2/en
Publication of WO2008079705A3 publication Critical patent/WO2008079705A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The present invention is directed to a polypeptide (hGOAT), a novel acyl- transferase. The present invention is also directed to nucleic acids encoding hGOAT and methods of assaying this acyl-transferase.
PCT/US2007/087334 2006-12-20 2007-12-13 Acyl-transferase WO2008079705A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07855109A EP2102232A2 (en) 2006-12-20 2007-12-13 Acyl-transferase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87087906P 2006-12-20 2006-12-20
US60/870,879 2006-12-20

Publications (2)

Publication Number Publication Date
WO2008079705A2 WO2008079705A2 (en) 2008-07-03
WO2008079705A3 true WO2008079705A3 (en) 2008-10-09

Family

ID=39563162

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/087334 WO2008079705A2 (en) 2006-12-20 2007-12-13 Acyl-transferase

Country Status (2)

Country Link
EP (1) EP2102232A2 (en)
WO (1) WO2008079705A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7544466B1 (en) 2007-12-29 2009-06-09 Board Of Regents, The University Of Texas System Ghrelin o-acyltransferase (GOAT) biochemical assay
WO2011053821A1 (en) 2009-10-30 2011-05-05 Tranzyme Pharma, Inc. Macrocyclic ghrelin receptor antagonists and inverse agonists and methods of using the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004093804A2 (en) * 2003-04-18 2004-11-04 Five Prime Therapeutics, Inc. Human polypeptides encoded by polynucleotides and methods of their use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004093804A2 (en) * 2003-04-18 2004-11-04 Five Prime Therapeutics, Inc. Human polypeptides encoded by polynucleotides and methods of their use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 1 May 2001 (2001-05-01), "Homo sapiens FKSG89 (FKSG89) mRNA, complete cds.", XP002489031, retrieved from EBI accession no. EMBL:AF359269 Database accession no. AF359269 *
GUTIERREZ J A ET AL: "Ghrelin octanoylation mediated by an orphan lipid transferase", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 20080429 US, vol. 105, no. 17, 29 April 2008 (2008-04-29), pages 6320 - 6325, XP002489029, ISSN: 0027-8424 1091-6490 *
KANAMOTO N ET AL: "Substantial production of ghrelin by a human medullary thyroid carcinoma cell line", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 2001 US, vol. 86, no. 10, 2001, pages 4984 - 4990, XP002489030, ISSN: 0021-972X *

Also Published As

Publication number Publication date
EP2102232A2 (en) 2009-09-23
WO2008079705A2 (en) 2008-07-03

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