WO2008078715A1 - Therapeutic agent for inflammatory myopathy containing il-6 antagonist as active ingredient - Google Patents
Therapeutic agent for inflammatory myopathy containing il-6 antagonist as active ingredient Download PDFInfo
- Publication number
- WO2008078715A1 WO2008078715A1 PCT/JP2007/074751 JP2007074751W WO2008078715A1 WO 2008078715 A1 WO2008078715 A1 WO 2008078715A1 JP 2007074751 W JP2007074751 W JP 2007074751W WO 2008078715 A1 WO2008078715 A1 WO 2008078715A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- therapeutic agent
- inflammatory myopathy
- antagonist
- active ingredient
- inflammatory
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
Abstract
It is intended to provide an excellent therapeutic agent for inflammatory myopathy which can significantly suppress symptoms of inflammatory myopathy such as abnormal inflammatory cell infiltration in muscle fibers and does not have disadvantages of conventional drugs such as a general decrease in immunocompetence. That is, the invention relates to a therapeutic agent for inflammatory myopathy characterized by containing IL-6 antagonist as an active ingredient. In the therapeutic agent for inflammatory myopathy, the IL-6 antagonist is preferably an antibody against IL-6 receptor, a monoclonal antibody or the like.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006351695A JP2010095445A (en) | 2006-12-27 | 2006-12-27 | Therapeutic agent for inflammatory myopathy containing il-6 antagonist as active ingredient |
JP2006-351695 | 2006-12-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008078715A1 true WO2008078715A1 (en) | 2008-07-03 |
Family
ID=39562504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2007/074751 WO2008078715A1 (en) | 2006-12-27 | 2007-12-21 | Therapeutic agent for inflammatory myopathy containing il-6 antagonist as active ingredient |
Country Status (5)
Country | Link |
---|---|
JP (1) | JP2010095445A (en) |
AR (1) | AR064538A1 (en) |
CL (1) | CL2007003817A1 (en) |
PE (1) | PE20081547A1 (en) |
WO (1) | WO2008078715A1 (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8398980B2 (en) | 2004-03-24 | 2013-03-19 | Chugai Seiyaku Kabushiki Kaisha | Subtypes of humanized antibody against interleuken-6 receptor |
US8568720B2 (en) | 2007-12-27 | 2013-10-29 | Chugai Seiyaku Kabushiki Kaisha | High concentration antibody-containing liquid formulation |
US8580264B2 (en) | 2010-11-08 | 2013-11-12 | Genentech, Inc. | Subcutaneously administered anti-IL-6 receptor antibody |
US8709409B2 (en) | 2003-04-28 | 2014-04-29 | Chugai Seiyaku Kabushiki Kaisha | Method for treating rheumatoid arthritis by administering an anti-IL-6 antibody and methotrexate |
US8840884B2 (en) | 2002-02-14 | 2014-09-23 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing solution pharmaceuticals |
US9017677B2 (en) | 1997-03-21 | 2015-04-28 | Chugai Seiyaku Kabushiki Kaisha | Methods of treating a disease mediated by sensitized T cells |
US9255145B2 (en) | 2001-04-02 | 2016-02-09 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agent for chronic arthritides diseases of childhood-related diseases |
US10168326B2 (en) | 2013-07-04 | 2019-01-01 | F. Hoffmann-La Roche Inc. | Interference-suppressed immunoassay to detect anti-drug antibodies in serum samples |
US10501769B2 (en) | 2009-10-26 | 2019-12-10 | Hoffmann-La Roche Inc. | Method for the production of a glycosylated immunoglobulin |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0899902A (en) * | 1994-09-30 | 1996-04-16 | Chugai Pharmaceut Co Ltd | Immature type myeloma cell treating agent containing il--6 receptor as active ingredient |
JPH08208514A (en) * | 1994-10-07 | 1996-08-13 | Chugai Pharmaceut Co Ltd | Chronic articular rheumatism-treating medicine containing il-6 antagonist as active ingredient |
JPH10324639A (en) * | 1997-03-21 | 1998-12-08 | Chugai Pharmaceut Co Ltd | Preventing and therapeutic agent for disease associated with sensitized t cell containing il-6 antagonist as active ingredient |
WO1999047170A1 (en) * | 1998-03-17 | 1999-09-23 | Chugai Seiyaku Kabushiki Kaisha | Preventives or remedies for inflammatory intestinal diseases containing as the active ingredient il-6 antagonists |
WO2000010607A1 (en) * | 1998-08-24 | 2000-03-02 | Chugai Seiyaku Kabushiki Kaisha | Preventives or remedies for pancreatitis containing il-6 antagonists as the active ingredient |
WO2002080969A1 (en) * | 2001-04-02 | 2002-10-17 | Chugai Seiyaku Kabushiki Kaisha | Remedies for infant chronic arthritis-relating diseases |
WO2004039826A1 (en) * | 2001-11-14 | 2004-05-13 | Centocor, Inc. | Anti-il-6 antibodies, compositions, methods and uses |
WO2005061000A1 (en) * | 2003-12-19 | 2005-07-07 | Chugai Seiyaku Kabushiki Kaisha | Remedy for angitis |
-
2006
- 2006-12-27 JP JP2006351695A patent/JP2010095445A/en active Pending
-
2007
- 2007-12-21 WO PCT/JP2007/074751 patent/WO2008078715A1/en active Application Filing
- 2007-12-26 AR ARP070105906A patent/AR064538A1/en unknown
- 2007-12-26 CL CL200703817A patent/CL2007003817A1/en unknown
-
2008
- 2008-01-02 PE PE2008000015A patent/PE20081547A1/en not_active Application Discontinuation
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0899902A (en) * | 1994-09-30 | 1996-04-16 | Chugai Pharmaceut Co Ltd | Immature type myeloma cell treating agent containing il--6 receptor as active ingredient |
JPH08208514A (en) * | 1994-10-07 | 1996-08-13 | Chugai Pharmaceut Co Ltd | Chronic articular rheumatism-treating medicine containing il-6 antagonist as active ingredient |
JPH10324639A (en) * | 1997-03-21 | 1998-12-08 | Chugai Pharmaceut Co Ltd | Preventing and therapeutic agent for disease associated with sensitized t cell containing il-6 antagonist as active ingredient |
WO1999047170A1 (en) * | 1998-03-17 | 1999-09-23 | Chugai Seiyaku Kabushiki Kaisha | Preventives or remedies for inflammatory intestinal diseases containing as the active ingredient il-6 antagonists |
WO2000010607A1 (en) * | 1998-08-24 | 2000-03-02 | Chugai Seiyaku Kabushiki Kaisha | Preventives or remedies for pancreatitis containing il-6 antagonists as the active ingredient |
WO2002080969A1 (en) * | 2001-04-02 | 2002-10-17 | Chugai Seiyaku Kabushiki Kaisha | Remedies for infant chronic arthritis-relating diseases |
WO2004039826A1 (en) * | 2001-11-14 | 2004-05-13 | Centocor, Inc. | Anti-il-6 antibodies, compositions, methods and uses |
WO2005061000A1 (en) * | 2003-12-19 | 2005-07-07 | Chugai Seiyaku Kabushiki Kaisha | Remedy for angitis |
Non-Patent Citations (1)
Title |
---|
SCUDERI F. ET AL.: "IL-6-deficient mice show impaired inflammatory response in a model of myosin-induced experimental myositis", JOURNAL OF NEUROIMMUNOLOGY, vol. 176, July 2006 (2006-07-01), pages 9 - 15, XP025039292, DOI: doi:10.1016/j.jneuroim.2006.03.026 * |
Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9017677B2 (en) | 1997-03-21 | 2015-04-28 | Chugai Seiyaku Kabushiki Kaisha | Methods of treating a disease mediated by sensitized T cells |
US9255145B2 (en) | 2001-04-02 | 2016-02-09 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agent for chronic arthritides diseases of childhood-related diseases |
US8840884B2 (en) | 2002-02-14 | 2014-09-23 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing solution pharmaceuticals |
US9051384B2 (en) | 2002-02-14 | 2015-06-09 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing solution formulations |
US10744201B2 (en) | 2003-04-28 | 2020-08-18 | Chugai Seiyaku Kabushiki Kaisha | Method for treating rheumatoid arthritis with a human IL-6 receptor antibody and methotrexate |
US8709409B2 (en) | 2003-04-28 | 2014-04-29 | Chugai Seiyaku Kabushiki Kaisha | Method for treating rheumatoid arthritis by administering an anti-IL-6 antibody and methotrexate |
US9902777B2 (en) | 2004-03-24 | 2018-02-27 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing subtypes of humanized antibody against interleukin-6 receptor |
US8398980B2 (en) | 2004-03-24 | 2013-03-19 | Chugai Seiyaku Kabushiki Kaisha | Subtypes of humanized antibody against interleuken-6 receptor |
US8734800B2 (en) | 2004-03-24 | 2014-05-27 | Chugai Seiyaku Kabushiki Kaisha | Subtypes of humanized antibody against interleukin-6 receptor |
US11008394B2 (en) | 2007-12-27 | 2021-05-18 | Chugai Seiyaku Kabushiki Kaisha | High concentration antibody-containing liquid formulation |
US8568720B2 (en) | 2007-12-27 | 2013-10-29 | Chugai Seiyaku Kabushiki Kaisha | High concentration antibody-containing liquid formulation |
US11767363B2 (en) | 2007-12-27 | 2023-09-26 | Chugai Seiyaku Kabushiki Kaisha | High concentration antibody-containing liquid formulation |
US11584798B2 (en) | 2007-12-27 | 2023-02-21 | Hoffmann-La Roche Inc. | High concentration antibody-containing liquid formulation |
US11359026B2 (en) | 2007-12-27 | 2022-06-14 | Chugai Seiyaku Kabushiki Kaisha | High concentration antibody-containing liquid formulation |
US10501769B2 (en) | 2009-10-26 | 2019-12-10 | Hoffmann-La Roche Inc. | Method for the production of a glycosylated immunoglobulin |
US11021728B2 (en) | 2009-10-26 | 2021-06-01 | Hoffmann-La Roche Inc. | Method for the production of a glycosylated immunoglobulin |
US11136610B2 (en) | 2009-10-26 | 2021-10-05 | Hoffmann-La Roche Inc. | Method for the production of a glycosylated immunoglobulin |
US11377678B2 (en) | 2009-10-26 | 2022-07-05 | Hoffman-La Roche Inc. | Method for the production of a glycosylated immunoglobulin |
US8580264B2 (en) | 2010-11-08 | 2013-11-12 | Genentech, Inc. | Subcutaneously administered anti-IL-6 receptor antibody |
US10874677B2 (en) | 2010-11-08 | 2020-12-29 | Hoffmann-La Roche Inc. | Subcutaneously administered anti-IL-6 receptor antibody |
US9750752B2 (en) | 2010-11-08 | 2017-09-05 | Hoffmann-La Roche Inc. | Subcutaneously administered anti-IL-6 receptor antibody |
US10231981B2 (en) | 2010-11-08 | 2019-03-19 | Chugai Seiyaku Kabushiki Kaisha | Subcutaneously administered anti-IL-6 receptor antibody for treatment of juvenile idiopathic arthritis |
US11622969B2 (en) | 2010-11-08 | 2023-04-11 | Hoffmann-La Roche Inc. | Subcutaneously administered anti-IL-6 receptor antibody |
US11667720B1 (en) | 2010-11-08 | 2023-06-06 | Hoffmann-La Roche Inc. | Subcutaneously administered anti-IL-6 receptor antibody |
US9539263B2 (en) | 2010-11-08 | 2017-01-10 | Genentech, Inc. | Subcutaneously administered anti-IL-6 receptor antibody for treatment of systemic sclerosis |
US10761091B2 (en) | 2013-07-04 | 2020-09-01 | Hoffmann-La Roche, Inc. | Interference-suppressed immunoassay to detect anti-drug antibodies in serum samples |
US10168326B2 (en) | 2013-07-04 | 2019-01-01 | F. Hoffmann-La Roche Inc. | Interference-suppressed immunoassay to detect anti-drug antibodies in serum samples |
Also Published As
Publication number | Publication date |
---|---|
JP2010095445A (en) | 2010-04-30 |
CL2007003817A1 (en) | 2008-06-27 |
AR064538A1 (en) | 2009-04-08 |
PE20081547A1 (en) | 2009-01-18 |
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