WO2008078109A3 - Medicament - Google Patents

Medicament Download PDF

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Publication number
WO2008078109A3
WO2008078109A3 PCT/GB2007/005010 GB2007005010W WO2008078109A3 WO 2008078109 A3 WO2008078109 A3 WO 2008078109A3 GB 2007005010 W GB2007005010 W GB 2007005010W WO 2008078109 A3 WO2008078109 A3 WO 2008078109A3
Authority
WO
WIPO (PCT)
Prior art keywords
agelastatin
medicament
metastasis
modulators
analogue
Prior art date
Application number
PCT/GB2007/005010
Other languages
French (fr)
Other versions
WO2008078109A2 (en
Inventor
Mohamed K. El-Tanani
Karl J. Hale
Soraya Manaviazar
Patrick G. Johnston
Original Assignee
The Queen's University Of Belfast
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Queen's University Of Belfast filed Critical The Queen's University Of Belfast
Publication of WO2008078109A2 publication Critical patent/WO2008078109A2/en
Publication of WO2008078109A3 publication Critical patent/WO2008078109A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

There is disclosed the use of (-)-Agelastatin and / or an agelastatin analogue in the treatment of metastatic disease, pharmaceutical compositions comprising Agelastatin and other active agents, for example chemotherapeutic agents and an assay for the identification of modulators of metastasis and / or invasive cancer.
PCT/GB2007/005010 2006-12-22 2007-12-24 Medicament WO2008078109A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0625783.6 2006-12-22
GBGB0625783.6A GB0625783D0 (en) 2006-12-22 2006-12-22 Medicament

Publications (2)

Publication Number Publication Date
WO2008078109A2 WO2008078109A2 (en) 2008-07-03
WO2008078109A3 true WO2008078109A3 (en) 2009-09-11

Family

ID=37758951

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/005010 WO2008078109A2 (en) 2006-12-22 2007-12-24 Medicament

Country Status (2)

Country Link
GB (1) GB0625783D0 (en)
WO (1) WO2008078109A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
WO2015042239A1 (en) 2013-09-19 2015-03-26 Massachusetts Institute Of Technology Compounds, compositions and methods of agelastatin alkaloids
WO2017197045A1 (en) 2016-05-11 2017-11-16 Movassaghi Mohammad Convergent and enantioselective total synthesis of communesin analogs
WO2018209239A1 (en) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
CA3218791A1 (en) * 2021-05-11 2022-11-17 Baylor University Agelastatin a derivatives and related methods

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004106343A2 (en) * 2003-05-30 2004-12-09 Ufc Limited Agelastatin derivatives of antitumour and gsk-3beta-inhibiting alkaloids
WO2006055578A2 (en) * 2004-11-16 2006-05-26 Temple University - Of The Commonwealth Systems Of Higher Education Asymmetric synthesis of (-)-agelastatin a

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004106343A2 (en) * 2003-05-30 2004-12-09 Ufc Limited Agelastatin derivatives of antitumour and gsk-3beta-inhibiting alkaloids
WO2006055578A2 (en) * 2004-11-16 2006-05-26 Temple University - Of The Commonwealth Systems Of Higher Education Asymmetric synthesis of (-)-agelastatin a

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FURGER K A ET AL: "THE FUNCTIONAL AND CLINICAL ROLES OF OSTEOPONTIN IN CANCER AND METASTASIS", CURRENT MOLECULAR MEDICINE, BENTHAM SCIENCE PUBLISHERS, vol. 1, no. 5, 1 January 2001 (2001-01-01), pages 621 - 632, XP008055151, ISSN: 1566-5240 *
HALE KARL J ET AL: "Chemical biology and mechanism of action studies on the antitumour agent, (-)-Agelastatin A.", ABSTRACTS OF PAPERS AMERICAN CHEMICAL SOCIETY, vol. 228, no. Part 1, August 2004 (2004-08-01), & MEETING OF THE DIVISION OF CHEMICAL TOXICOLOGY OF THE AMERICAN-CHEMICAL-SOCIETY HELD AT THE 228TH N; PHILADELPHIA, PA, USA; AUGUST 22 -26, 2004, pages U909, XP009112708, ISSN: 0065-7727 *

Also Published As

Publication number Publication date
GB0625783D0 (en) 2007-02-07
WO2008078109A2 (en) 2008-07-03

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