WO2008066755A3 - Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents - Google Patents

Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents Download PDF

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Publication number
WO2008066755A3
WO2008066755A3 PCT/US2007/024319 US2007024319W WO2008066755A3 WO 2008066755 A3 WO2008066755 A3 WO 2008066755A3 US 2007024319 W US2007024319 W US 2007024319W WO 2008066755 A3 WO2008066755 A3 WO 2008066755A3
Authority
WO
WIPO (PCT)
Prior art keywords
tyrosine kinase
apicomplexan
kinase inhibitors
kinetolastid
agents
Prior art date
Application number
PCT/US2007/024319
Other languages
French (fr)
Other versions
WO2008066755A2 (en
Inventor
Kojo Mensa-Wilmot
Original Assignee
Univ Georgia Res Found
Kojo Mensa-Wilmot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgia Res Found, Kojo Mensa-Wilmot filed Critical Univ Georgia Res Found
Priority to US12/446,286 priority Critical patent/US8338433B2/en
Priority to EP07867556A priority patent/EP2088863A2/en
Priority to CA002669531A priority patent/CA2669531A1/en
Publication of WO2008066755A2 publication Critical patent/WO2008066755A2/en
Publication of WO2008066755A3 publication Critical patent/WO2008066755A3/en
Priority to US13/676,326 priority patent/US9545410B2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention provides methods of killing, inhibiting the growth, and/or inhibiting the reproduction of kinetoplastid or apicomplexan protozoan with tyrosine kinase inhibitors.
PCT/US2007/024319 2006-11-22 2007-11-21 Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents WO2008066755A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/446,286 US8338433B2 (en) 2006-11-22 2007-11-21 Tyrosine kinase inhibitors as anti-kinetoplastid agents
EP07867556A EP2088863A2 (en) 2006-11-22 2007-11-21 Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents
CA002669531A CA2669531A1 (en) 2006-11-22 2007-11-21 Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents
US13/676,326 US9545410B2 (en) 2006-11-22 2012-11-14 Tyrosine kinase inhibitors as anti-kinetoplastid agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86071706P 2006-11-22 2006-11-22
US60/860,717 2006-11-22

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/446,286 A-371-Of-International US8338433B2 (en) 2006-11-22 2007-11-21 Tyrosine kinase inhibitors as anti-kinetoplastid agents
US13/676,326 Division US9545410B2 (en) 2006-11-22 2012-11-14 Tyrosine kinase inhibitors as anti-kinetoplastid agents

Publications (2)

Publication Number Publication Date
WO2008066755A2 WO2008066755A2 (en) 2008-06-05
WO2008066755A3 true WO2008066755A3 (en) 2009-01-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/024319 WO2008066755A2 (en) 2006-11-22 2007-11-21 Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents

Country Status (4)

Country Link
US (2) US8338433B2 (en)
EP (1) EP2088863A2 (en)
CA (1) CA2669531A1 (en)
WO (1) WO2008066755A2 (en)

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US8246966B2 (en) 2006-08-07 2012-08-21 University Of Georgia Research Foundation, Inc. Trypanosome microsome system and uses thereof
WO2008066755A2 (en) 2006-11-22 2008-06-05 University Of Georgia Research Foundation, Inc. Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents
US8916574B2 (en) * 2009-09-28 2014-12-23 Qilu Pharmaceutical Co., Ltd. 4-(substituted anilino)-quinazoline derivatives useful as tyrosine kinase inhibitors
US9765037B2 (en) 2010-01-28 2017-09-19 University Of Washington Through Its Center For Commercialization Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases
EP2528919B1 (en) * 2010-01-28 2016-11-02 University of Washington Compositions and methods for treating toxoplasmosis. cryptosporidiosis and other apicomplexan protozoan related diseases
CN102766209B (en) * 2012-07-04 2014-09-10 中国检验检疫科学研究院 Monoclonal antibody of anti-perkinsus membrane protein, preparation method and application thereof
KR101441096B1 (en) 2012-11-27 2014-09-25 가톨릭대학교 산학협력단 Composition for preventing and treating Toxoplasma gondii infection comprising gefitinib
US9518026B2 (en) 2013-05-20 2016-12-13 University Of Washington Through Its Center For Commercialization 5-aminopyrazole-4-carboxamide inhibitors of CDPK1 from T. gondii and C. parvum
CN105377262A (en) * 2013-07-11 2016-03-02 普雷西恩护肤公司 Topical treatment of localized scleroderma
KR101508611B1 (en) * 2013-09-02 2015-04-08 가톨릭대학교 산학협력단 Composition for preventing and treating Toxoplasma gondii infection comprising afatinib
KR101508610B1 (en) * 2013-09-02 2015-04-08 가톨릭대학교 산학협력단 Composition for preventing and treating Toxoplasma gondii infection comprising dacomitinib
KR101540739B1 (en) 2013-09-02 2015-08-05 가톨릭대학교 산학협력단 Composition for preventing and treating Toxoplasma gondii infection comprising pelitinib
WO2015030504A1 (en) * 2013-09-02 2015-03-05 가톨릭대학교 산학협력단 Pharmaceutical composition for prevention or treatment of toxoplasmosis, comprising anti-non-small cell lung cancer agent as active ingredient
KR101538385B1 (en) * 2013-09-02 2015-07-29 가톨릭대학교 산학협력단 Composition for preventing and treating Toxoplasma gondii infection comprising crizotinib
WO2015103026A2 (en) * 2014-01-03 2015-07-09 The Regents Of The University Of Michigan Treatment of neurological disorders
PT3134119T (en) * 2014-04-24 2018-11-07 Pfizer Cancer treatment

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Also Published As

Publication number Publication date
CA2669531A1 (en) 2008-06-05
US20130072484A1 (en) 2013-03-21
EP2088863A2 (en) 2009-08-19
WO2008066755A2 (en) 2008-06-05
US9545410B2 (en) 2017-01-17
US20100311742A1 (en) 2010-12-09
US8338433B2 (en) 2012-12-25

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