WO2008065544A3 - Genetic predictors of risk for type 2 diabetes mellitus - Google Patents

Genetic predictors of risk for type 2 diabetes mellitus Download PDF

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Publication number
WO2008065544A3
WO2008065544A3 PCT/IB2007/004361 IB2007004361W WO2008065544A3 WO 2008065544 A3 WO2008065544 A3 WO 2008065544A3 IB 2007004361 W IB2007004361 W IB 2007004361W WO 2008065544 A3 WO2008065544 A3 WO 2008065544A3
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WO
WIPO (PCT)
Prior art keywords
risk
type
diabetes mellitus
t2dm
genetic predictors
Prior art date
Application number
PCT/IB2007/004361
Other languages
French (fr)
Other versions
WO2008065544A2 (en
Inventor
Constantin Polychronakos
Rob Sladek
Philippe Froguel
Original Assignee
Univ Mcgill
Constantin Polychronakos
Rob Sladek
Philippe Froguel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Mcgill, Constantin Polychronakos, Rob Sladek, Philippe Froguel filed Critical Univ Mcgill
Publication of WO2008065544A2 publication Critical patent/WO2008065544A2/en
Publication of WO2008065544A3 publication Critical patent/WO2008065544A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Methods of analyzing individuals at risk for the development of Type 2 diabetes mellitus (T2DM). Nucleic acids obtained from biological samples of individuals suffering from T2DM have been analyzed and SNPs associated with T2DM genes have been discovered. In addition, SNPs in linkage disequilibrium with T2DM genes are described.
PCT/IB2007/004361 2006-09-11 2007-09-11 Genetic predictors of risk for type 2 diabetes mellitus WO2008065544A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84358606P 2006-09-11 2006-09-11
US60/843,586 2006-09-11

Publications (2)

Publication Number Publication Date
WO2008065544A2 WO2008065544A2 (en) 2008-06-05
WO2008065544A3 true WO2008065544A3 (en) 2009-03-19

Family

ID=39468332

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/004361 WO2008065544A2 (en) 2006-09-11 2007-09-11 Genetic predictors of risk for type 2 diabetes mellitus

Country Status (1)

Country Link
WO (1) WO2008065544A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2494361B2 (en) 2009-10-26 2019-01-09 Externautics S.p.A. Ovary tumor markers and methods of use thereof
US20120322075A1 (en) 2009-10-26 2012-12-20 Externautics S.P.A. Lung Tumor Markers and Methods of Use Thereof
WO2011051276A1 (en) 2009-10-26 2011-05-05 Externautics S.P.A. Colon and rectal tumor markers and methods of use thereof
CN104395479B (en) * 2012-01-27 2019-03-15 香港中文大学 The biomarker of diabetes
KR20230005816A (en) * 2020-03-06 2023-01-10 드노보 바이오파마 엘엘씨 Compositions and methods for evaluating the efficacy of neurotransmitter transporter inhibitors

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004042358A2 (en) * 2002-11-01 2004-05-21 Decode Genetics Ehf. HUMAN TYPE II DIABETES GENE-SLIT-3 LOCATED ON CHROMOSOME 5q35
FR2847263A1 (en) * 2002-11-18 2004-05-21 Commissariat Energie Atomique New nucleic acid encoding a zinc transporter, useful for diagnosis and treatment of diabetes, also derived proteins, antibodies, transformed cells and organisms, and method for selected islet beta cells
US20050147987A1 (en) * 2000-09-08 2005-07-07 Applera Corporation (Ny) Polymorphisms in known genes associated with type II diabetes and obesity, methods of detection and uses thereof
WO2006022634A1 (en) * 2004-07-22 2006-03-02 Sequenom, Inc. Methods for identifying risk of type ii diabetes and treatments thereof
WO2008065682A2 (en) * 2006-11-30 2008-06-05 Decode Genetics Ehf. Genetic susceptibility variants of type 2 diabetes mellitus

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050147987A1 (en) * 2000-09-08 2005-07-07 Applera Corporation (Ny) Polymorphisms in known genes associated with type II diabetes and obesity, methods of detection and uses thereof
WO2004042358A2 (en) * 2002-11-01 2004-05-21 Decode Genetics Ehf. HUMAN TYPE II DIABETES GENE-SLIT-3 LOCATED ON CHROMOSOME 5q35
FR2847263A1 (en) * 2002-11-18 2004-05-21 Commissariat Energie Atomique New nucleic acid encoding a zinc transporter, useful for diagnosis and treatment of diabetes, also derived proteins, antibodies, transformed cells and organisms, and method for selected islet beta cells
WO2006022634A1 (en) * 2004-07-22 2006-03-02 Sequenom, Inc. Methods for identifying risk of type ii diabetes and treatments thereof
WO2008065682A2 (en) * 2006-11-30 2008-06-05 Decode Genetics Ehf. Genetic susceptibility variants of type 2 diabetes mellitus

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
DATABASE ENTREZ PROTEIN [online] NCBI; 18 May 2005 (2005-05-18), "CAH72347. Reports calmodulin bindin...[gi:55665770]", XP002497998, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV/ENTREZ/VIEWER.FCGI?DB=PROTEIN Database accession no. 55665770 *
DATABASE ENTREZ PROTEIN [online] NCBI; 7 May 2008 (2008-05-07), "CAH72347. Reports calmodulin bindin...[gi:55665770]", XP002497997, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV/ENTREZ/VIEWER.FCGI?DB=PROTEIN Database accession no. 55665770 *
DATABASE PROBE [online] ncbi; 22 February 2006 (2006-02-22), "rs13266634", XP002509338, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV Database accession no. Pr003758580.1 *
DATABASE SNP [online] NCBI; 10 October 2003 (2003-10-10), "rs1193179", XP002497772, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV Database accession no. rs1193179 *
DATABASE SNP [online] NCBI; 13 September 2004 (2004-09-13), "rs3266634", XP002509337, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV Database accession no. rs13266634 *
DIABETES GENETICS INITIATIVE OF BROAD INSTITUTE OF HARVARD AND MIT, LUND UNIVERSITY, AND NOVARTIS INSTITUTES OF BIOMEDICAL RESEARC: "Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.", SCIENCE (NEW YORK, N.Y.) 1 JUN 2007, vol. 316, no. 5829, 1 June 2007 (2007-06-01), pages 1331 - 1336, XP002509336, ISSN: 1095-9203 *
GRANT STRUAN F A ET AL: "Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes", NATURE GENETICS, NATURE PUBLISHING GROUP, NEW YORK, US, vol. 38, no. 3, 1 March 2006 (2006-03-01), pages 320 - 323, XP009096714, ISSN: 1061-4036 *
KANG EUN SEOK ET AL: "The influence of adiponectin gene polymorphism on the rosiglitazone response in patients with type 2 diabetes.", May 2005, DIABETES CARE MAY 2005, VOL. 28, NR. 5, PAGE(S) 1139 - 1144, ISSN: 0149-5992, XP002496473 *
SLADEK ROBERT ET AL: "A genome-wide association study identifies novel risk loci for type 2 diabetes", NATURE, NATURE PUBLISHING GROUP, LONDON, UK, vol. 445, no. 7130, 22 February 2007 (2007-02-22), pages 881 - 885, XP002465137, ISSN: 0028-0836 *
STEPHANE CAUCHI ET AL: "Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study", 22 January 2008, JOURNAL OF MOLECULAR MEDICINE, SPRINGER, BERLIN, DE, PAGE(S) 341 - 348, ISSN: 1432-1440, XP019576423 *

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