WO2008065107A8 - Storage stable tablets based on benzimidazole derivatives coated with a gastro-resistant film - Google Patents

Storage stable tablets based on benzimidazole derivatives coated with a gastro-resistant film

Info

Publication number
WO2008065107A8
WO2008065107A8 PCT/EP2007/062879 EP2007062879W WO2008065107A8 WO 2008065107 A8 WO2008065107 A8 WO 2008065107A8 EP 2007062879 W EP2007062879 W EP 2007062879W WO 2008065107 A8 WO2008065107 A8 WO 2008065107A8
Authority
WO
WIPO (PCT)
Prior art keywords
gastro
core
benzimidazole derivatives
resistant film
storage stable
Prior art date
Application number
PCT/EP2007/062879
Other languages
French (fr)
Other versions
WO2008065107A1 (en
Inventor
Celestino Ronchi
Giancarlo Ceschel
Manuela Astulfoni
Original Assignee
Monteres S R L
Celestino Ronchi
Giancarlo Ceschel
Manuela Astulfoni
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monteres S R L, Celestino Ronchi, Giancarlo Ceschel, Manuela Astulfoni filed Critical Monteres S R L
Publication of WO2008065107A1 publication Critical patent/WO2008065107A1/en
Publication of WO2008065107A8 publication Critical patent/WO2008065107A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Moisture-resistant tablets containing as active principles benzimidazole derivatives and more specifically prazoles, comprising: a) a rapidly disintegrating core containing the active principle, b) a moisture-resistant rapidly disintegrating barrier layer, stabilizing and protecting of the core, applied by compression to the core (a) so as to completely envelop it, characterized in that all the operating steps for both core (a) and outer layer (b) preparation are undertaken in the dry state. Said tablet can be completely coated with a gastro-resistant film applied by conventional techniques.
PCT/EP2007/062879 2006-11-28 2007-11-27 Storage stable tablets based on benzimidazole derivatives coated with a gastro-resistant film WO2008065107A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2006A002290 2006-11-28
ITMI20062290 ITMI20062290A1 (en) 2006-11-28 2006-11-28 TABLETS STABLE WITH STORAGE BASED ON BENZIMIDAZOLE DERIVATIVES COATED WITH GASTRO-RESISTANT FILM

Publications (2)

Publication Number Publication Date
WO2008065107A1 WO2008065107A1 (en) 2008-06-05
WO2008065107A8 true WO2008065107A8 (en) 2008-09-12

Family

ID=38964891

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/062879 WO2008065107A1 (en) 2006-11-28 2007-11-27 Storage stable tablets based on benzimidazole derivatives coated with a gastro-resistant film

Country Status (2)

Country Link
IT (1) ITMI20062290A1 (en)
WO (1) WO2008065107A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010122583A2 (en) * 2009-04-24 2010-10-28 Rubicon Research Private Limited Oral pharmaceutical compositions of acid labile substances
WO2011111027A2 (en) 2010-03-11 2011-09-15 Dexcel Pharma Technologies Ltd. Oral dispersible delayed release tablet formulation
US20150313847A1 (en) * 2012-12-07 2015-11-05 Gumlink A/S Compressed Tablets

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0995447A1 (en) * 1993-09-09 2000-04-26 Takeda Chemical Industries, Ltd. Formulation comprising antibacterial substance and antiulcer substance
SE9600070D0 (en) * 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
GB9710800D0 (en) * 1997-05-23 1997-07-23 Cipla Limited Pharmaceutical composition and method of preparing it
SE9704870D0 (en) * 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulation I
WO2003032953A1 (en) * 2001-10-17 2003-04-24 Takeda Chemical Industries, Ltd. Granules containing acid-unstable chemical in large amount
US20050191353A1 (en) * 2002-08-16 2005-09-01 Amit Krishna Antarkar Process for manufacture of stable oral multiple unit pharmaceutical composition containing benzimidazoles
ATE454906T1 (en) * 2003-07-11 2010-01-15 Astrazeneca Ab SOLID COMPOSITION CONTAINING A PROTON PUMP INHIBITOR
WO2005051362A2 (en) * 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited Oral benzimidazole compositions comprising an active core, an optional separating layer and an enteric coating
EP1722762A2 (en) * 2004-03-02 2006-11-22 Massachusetts Institute of Technology Nanocell drug delivery system
WO2006011159A2 (en) * 2004-06-21 2006-02-02 Torrent Pharmaceuticals Limited Stabilized pharmaceutical composition containing rabeprazole sodium with improved bioavailability
US20060024362A1 (en) * 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture
WO2006085335A2 (en) * 2005-01-03 2006-08-17 Lupin Limited Pharmaceutical composition of acid labile substances
US20060210637A1 (en) * 2005-03-17 2006-09-21 Qpharma, Llc Stable tablet dosage forms of proton pump inhibitors

Also Published As

Publication number Publication date
ITMI20062290A1 (en) 2008-05-29
WO2008065107A1 (en) 2008-06-05

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