WO2008064136A3 - Compounds with activity at retinoic acid receptors - Google Patents

Compounds with activity at retinoic acid receptors Download PDF

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Publication number
WO2008064136A3
WO2008064136A3 PCT/US2007/085027 US2007085027W WO2008064136A3 WO 2008064136 A3 WO2008064136 A3 WO 2008064136A3 US 2007085027 W US2007085027 W US 2007085027W WO 2008064136 A3 WO2008064136 A3 WO 2008064136A3
Authority
WO
WIPO (PCT)
Prior art keywords
disorder
activity
compounds
retinoic acid
acid receptors
Prior art date
Application number
PCT/US2007/085027
Other languages
French (fr)
Other versions
WO2008064136A2 (en
Inventor
Roger Olsson
Fabrice Piu
Birgitte Winther Lund
Original Assignee
Acadia Pharm Inc
Roger Olsson
Fabrice Piu
Birgitte Winther Lund
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acadia Pharm Inc, Roger Olsson, Fabrice Piu, Birgitte Winther Lund filed Critical Acadia Pharm Inc
Publication of WO2008064136A2 publication Critical patent/WO2008064136A2/en
Publication of WO2008064136A3 publication Critical patent/WO2008064136A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Disclosed herein is a compound of Formula (I) and pharmaceutical composition comprising the same. Also disclosed herein are methods of treating, or alleviating the symptoms of, a disease comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I). The disease may be selected from the group consisting of cancer, hyperproliferative disorder, inflammatory disorder, neurological disorder, neurodegenerative disorder, eye disorder, eye condition, depression, pulmonary disorders/conditions, dermatological disorders/conditions, and infertility.
PCT/US2007/085027 2006-11-17 2007-11-16 Compounds with activity at retinoic acid receptors WO2008064136A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86636006P 2006-11-17 2006-11-17
US60/866,360 2006-11-17

Publications (2)

Publication Number Publication Date
WO2008064136A2 WO2008064136A2 (en) 2008-05-29
WO2008064136A3 true WO2008064136A3 (en) 2008-07-10

Family

ID=39430527

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/085027 WO2008064136A2 (en) 2006-11-17 2007-11-16 Compounds with activity at retinoic acid receptors

Country Status (1)

Country Link
WO (1) WO2008064136A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
EP2329817A1 (en) * 2009-09-04 2011-06-08 Ernst-Moritz-Arndt-Universität Greifswald Retinoic acid receptor antagonists, miR-10a inhibitors and inhibitors of HOXB1 or HOXB3 repressors for treating pancreatic cancer
GB0915523D0 (en) 2009-09-07 2009-10-07 Genome Res Ltd Cells and methods for obtaining them
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
EP2864332B1 (en) * 2012-06-22 2016-12-28 The Board of Trustees of The Leland Stanford Junior University Imidazo bicyclic imminium compounds as antitumor agents
GB201321743D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
WO2015109231A1 (en) 2014-01-17 2015-07-23 Cornell University Methods of treating metabolic syndrome related conditions using retinoic acid receptor agonists
WO2015138354A1 (en) 2014-03-10 2015-09-17 Cornell University Combination therapy for head and neck cancer

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110959A (en) * 1996-03-18 2000-08-29 Eisai Co., Ltd. Carboxylic acid derivatives having fused rings
US6521814B1 (en) * 1997-12-22 2003-02-18 Institut National De La Santa Et De La Recherche Medicale Use of ligands for treatment of diseases responsive to retinoids
US6545009B1 (en) * 1998-07-01 2003-04-08 Takeda Chemical Industries, Ltd. Retinoid-related receptor function regulating agent
US6603012B2 (en) * 2000-05-02 2003-08-05 Hoffmann-La Roche Inc. RAR selective retinoid agonists
EP1657242A1 (en) * 2003-08-15 2006-05-17 Banyu Pharmaceutical Co., Ltd. Imidazopyridine derivatives
US20060134670A1 (en) * 2004-11-19 2006-06-22 Fabrice Piu Enabling tools to identify ligands for hormone nuclear receptors
US7087636B2 (en) * 2001-12-19 2006-08-08 Bristol-Myers Squibb Company Fused heterocyclic compounds and analogs thereof, modulators of nuclear hormone receptor function

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110959A (en) * 1996-03-18 2000-08-29 Eisai Co., Ltd. Carboxylic acid derivatives having fused rings
US6521814B1 (en) * 1997-12-22 2003-02-18 Institut National De La Santa Et De La Recherche Medicale Use of ligands for treatment of diseases responsive to retinoids
US6545009B1 (en) * 1998-07-01 2003-04-08 Takeda Chemical Industries, Ltd. Retinoid-related receptor function regulating agent
US6603012B2 (en) * 2000-05-02 2003-08-05 Hoffmann-La Roche Inc. RAR selective retinoid agonists
US7087636B2 (en) * 2001-12-19 2006-08-08 Bristol-Myers Squibb Company Fused heterocyclic compounds and analogs thereof, modulators of nuclear hormone receptor function
EP1657242A1 (en) * 2003-08-15 2006-05-17 Banyu Pharmaceutical Co., Ltd. Imidazopyridine derivatives
US20060134670A1 (en) * 2004-11-19 2006-06-22 Fabrice Piu Enabling tools to identify ligands for hormone nuclear receptors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WELLS: "Ichthyosis", BRITISH MED. JOURNAL, vol. 2, 1966, pages 1504 - 1506 *

Also Published As

Publication number Publication date
WO2008064136A2 (en) 2008-05-29

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