WO2008061673A3 - Drug discovery for cancer - Google Patents

Drug discovery for cancer Download PDF

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Publication number
WO2008061673A3
WO2008061673A3 PCT/EP2007/009910 EP2007009910W WO2008061673A3 WO 2008061673 A3 WO2008061673 A3 WO 2008061673A3 EP 2007009910 W EP2007009910 W EP 2007009910W WO 2008061673 A3 WO2008061673 A3 WO 2008061673A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
gamma
cancer
secretase
collection
Prior art date
Application number
PCT/EP2007/009910
Other languages
French (fr)
Other versions
WO2008061673A2 (en
Inventor
Loo Karen Miriam Johanna Van
Gerardus Johannes Maria Martens
Original Assignee
Synthon Bv
Loo Karen Miriam Johanna Van
Gerardus Johannes Maria Martens
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv, Loo Karen Miriam Johanna Van, Gerardus Johannes Maria Martens filed Critical Synthon Bv
Publication of WO2008061673A2 publication Critical patent/WO2008061673A2/en
Publication of WO2008061673A3 publication Critical patent/WO2008061673A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to a method for identifying compounds which alter the activity of gamma- secretase, comprising providing a collection of compounds; contacting the compounds of the collection with a cell line or organism expressing gamma-secretase; measuring the gamma-secretase activity in the cell line or organism before and after the contact with the compound; and identifying the compounds in the collection that modulate the gamma-secretase activity of the cell line or organism as leads for the development of compounds for use in the treatment of cancer. The invention further relates to the compound thus identified and the use thereof in therapy.
PCT/EP2007/009910 2006-11-24 2007-11-08 Drug discovery for cancer WO2008061673A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2006011266 2006-11-24
EPPCT/EP2006/011266 2006-11-24

Publications (2)

Publication Number Publication Date
WO2008061673A2 WO2008061673A2 (en) 2008-05-29
WO2008061673A3 true WO2008061673A3 (en) 2008-10-02

Family

ID=39272707

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/009910 WO2008061673A2 (en) 2006-11-24 2007-11-08 Drug discovery for cancer

Country Status (1)

Country Link
WO (1) WO2008061673A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004073630A2 (en) * 2003-02-18 2004-09-02 Roskamp Research Llc Anti-angiogenic and anti-tumoral properties of beta and gamma secretase inhibitors
WO2004104037A1 (en) * 2003-05-26 2004-12-02 Sanofi-Aventis Deutschland Gmbh Method for screening inhibitors of the gamma-secretase
EP1702626A1 (en) * 2003-12-30 2006-09-20 Kowa Company Ltd. Inhibitor for the formation of gammad-secretase complex
WO2007028655A2 (en) * 2005-09-09 2007-03-15 H. Lundbeck A/S Drug discovery for neurodevelopmental disorders and their complications

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004073630A2 (en) * 2003-02-18 2004-09-02 Roskamp Research Llc Anti-angiogenic and anti-tumoral properties of beta and gamma secretase inhibitors
WO2004104037A1 (en) * 2003-05-26 2004-12-02 Sanofi-Aventis Deutschland Gmbh Method for screening inhibitors of the gamma-secretase
EP1702626A1 (en) * 2003-12-30 2006-09-20 Kowa Company Ltd. Inhibitor for the formation of gammad-secretase complex
WO2007028655A2 (en) * 2005-09-09 2007-03-15 H. Lundbeck A/S Drug discovery for neurodevelopmental disorders and their complications

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHIROTANI KEIRO ET AL: "Identification of distinct gamma-secretase complexes with different APH-1 variants", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 279, no. 40, 1 October 2004 (2004-10-01), pages 41340 - 41345, XP002418773, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2008061673A2 (en) 2008-05-29

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