WO2008058235A3 - Processes for the preparation of cinacalcet - Google Patents
Processes for the preparation of cinacalcet Download PDFInfo
- Publication number
- WO2008058235A3 WO2008058235A3 PCT/US2007/084073 US2007084073W WO2008058235A3 WO 2008058235 A3 WO2008058235 A3 WO 2008058235A3 US 2007084073 W US2007084073 W US 2007084073W WO 2008058235 A3 WO2008058235 A3 WO 2008058235A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- processes
- cinacalcet
- preparation
- hydrogen
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
- C07C209/50—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Abstract
There are described several processes for making a free base of cinacalcet. One of the described processes goes through an intermediate of the formula (II) where R1 and R2 are both hydrogen, or R1 and R2, together, form a double bond.
Applications Claiming Priority (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2061/CHE/2006 | 2006-11-08 | ||
IN2061CH2006 | 2006-11-08 | ||
US88523607P | 2007-01-17 | 2007-01-17 | |
US88523907P | 2007-01-17 | 2007-01-17 | |
US88524207P | 2007-01-17 | 2007-01-17 | |
US60/885,242 | 2007-01-17 | ||
US60/885,239 | 2007-01-17 | ||
US60/885,236 | 2007-01-17 | ||
US89021307P | 2007-02-16 | 2007-02-16 | |
US60/890,213 | 2007-02-16 | ||
IN524CH2007 | 2007-03-14 | ||
IN524/CHE/2007 | 2007-03-14 | ||
US96906207P | 2007-08-30 | 2007-08-30 | |
US60/969,062 | 2007-08-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008058235A2 WO2008058235A2 (en) | 2008-05-15 |
WO2008058235A3 true WO2008058235A3 (en) | 2008-10-02 |
Family
ID=39365372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/084073 WO2008058235A2 (en) | 2006-11-08 | 2007-11-08 | Processes for the preparation of cinacalcet |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008058235A2 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR070754A1 (en) * | 2007-09-18 | 2010-05-05 | Medichem Sa | IMPROVED PROCESS TO PREPARE CINACALCET CHLORHYDRATE |
KR20110028647A (en) * | 2008-07-08 | 2011-03-21 | 인드-스위프트 래버러토리즈 리미티드 | Process for preparing cinacalcet and pharmaceutically acceptable salts thereof |
US20110318417A1 (en) | 2008-12-08 | 2011-12-29 | Actavis Group Ptc Ehf | Highly pure cinacalcet or a pharmaceutically acceptable salt thereof |
CN102307845B (en) | 2009-02-19 | 2015-04-15 | Zach***股份公司 | Process for preparing cinacalcet hydrochloride |
WO2010103531A2 (en) | 2009-03-09 | 2010-09-16 | Megafine Pharma (P) Ltd. | A new method for the preparation of cinacalcet and new intermediates thereof |
IT1394987B1 (en) * | 2009-07-27 | 2012-08-07 | Dipharma Francis Srl | PROCEDURE FOR THE PREPARATION OF CINACALCET |
IT1396623B1 (en) * | 2009-11-26 | 2012-12-14 | Dipharma Francis Srl | PROCEDURE FOR THE PREPARATION OF CINACALCET AND ITS INTERMEDIATES |
US8921606B2 (en) | 2010-07-16 | 2014-12-30 | Hetero Research Foundation | Process for cinacalcet hydrochloride |
CN101993379B (en) * | 2010-10-22 | 2013-06-19 | 能特科技股份有限公司 | Preparation method of cinacalcet hydrochloride |
CN102718662A (en) * | 2012-07-12 | 2012-10-10 | 杭州新博思生物医药有限公司 | Method for preparing cinacalcet hydrochloride |
FR2995307A1 (en) | 2012-09-07 | 2014-03-14 | Prod Chim Auxiliaires Et De Synthese | PROCESS FOR THE PREPARATION OF CINACALCET AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS |
CN103193655B (en) * | 2013-04-15 | 2015-06-24 | 山东新华制药股份有限公司 | Method for preparing cinacalcet hydrochloride crystal form I |
WO2015071831A1 (en) * | 2013-11-18 | 2015-05-21 | Piramal Enterprises Limited | An improved process for minimising the formation of dehalogenated byproducts |
CN104774134B (en) * | 2014-01-09 | 2016-08-17 | 成都自豪药业有限公司 | Cinacalcet hydrochloride and the synthetic method of midbody compound thereof |
WO2017033134A1 (en) | 2015-08-26 | 2017-03-02 | Lupin Limited | Enzymatic process for the for preparation of (r)-1-(1-naphthyl) ethylamine, an intermediate of cinacalcet hydrochloride |
CN111018734B (en) * | 2019-12-13 | 2020-12-22 | 福建海西新药创制有限公司 | Synthesis method of cinacalcet hydrochloride intermediate |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6093830A (en) * | 1998-11-09 | 2000-07-25 | Council Of Scientific And Industrial Research | Enantioselective resolution process for arylpropionic acid drugs from the racemic mixture |
WO2004110976A2 (en) * | 2003-06-13 | 2004-12-23 | Avecia Pharmaceuticals Limited | Process for the preparation of aromatic amines |
-
2007
- 2007-11-08 WO PCT/US2007/084073 patent/WO2008058235A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6093830A (en) * | 1998-11-09 | 2000-07-25 | Council Of Scientific And Industrial Research | Enantioselective resolution process for arylpropionic acid drugs from the racemic mixture |
WO2004110976A2 (en) * | 2003-06-13 | 2004-12-23 | Avecia Pharmaceuticals Limited | Process for the preparation of aromatic amines |
Non-Patent Citations (4)
Title |
---|
CHANDRASEKHAR S. ET AL.: "Revisted mechanism and improved methodology for the Perkin condensation. Resuscitation of the mechanism involving benzyl acetate and the improbability of the enolate of acetic anhydride", TETRAHEDRON LETTERS, vol. 47, 27 March 2006 (2006-03-27), pages 2249 - 2251, XP005304059 * |
KITAMURA ET AL.: "Catalytic Leukart-Wallach-Type Reductive Animation of Ketones", J. ORG. CHEM., vol. 67, 2002, pages 8685 - 8687 * |
WANG X. ET AL.: "Synthesis of Cinacalcet congeners", TETRAHEDRON LETTERS, vol. 45, 2004, pages 8355 - 8358, XP004593872 * |
YAMAZAKI N. ET AL.: "Nucleophilic addition of methylithium to chiral oxime ethers: asymmetric preparation of 1-(aryl)ethylamines and application to a synthesis of calcimimetics (+)-NPS R-568 and its thio analogue", TETRAHEDRON LETTERS, vol. 42, 2001, pages 5029 - 5032, XP004250170 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008058235A2 (en) | 2008-05-15 |
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