WO2008057599A3 - Methods for the treatment of abeta related disorders and compositions therefor - Google Patents
Methods for the treatment of abeta related disorders and compositions therefor Download PDFInfo
- Publication number
- WO2008057599A3 WO2008057599A3 PCT/US2007/023663 US2007023663W WO2008057599A3 WO 2008057599 A3 WO2008057599 A3 WO 2008057599A3 US 2007023663 W US2007023663 W US 2007023663W WO 2008057599 A3 WO2008057599 A3 WO 2008057599A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- related disorders
- treatment
- methods
- compositions therefor
- abeta related
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
Abstract
The invention provides methods for treating Aβ peptide related disorders such as Alzheimer's disease comprising administering to a patient in need thereof a substituted 2-(pyrimidinylamino)-thiazole-5-carboxamides in free or pharmaceutically acceptable salt form, preferably dasatinib, in an amount effective to inhibit or reduce accumulation of Aβ peptide.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85833006P | 2006-11-10 | 2006-11-10 | |
US60/858,330 | 2006-11-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008057599A2 WO2008057599A2 (en) | 2008-05-15 |
WO2008057599A3 true WO2008057599A3 (en) | 2008-12-18 |
Family
ID=39365146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/023663 WO2008057599A2 (en) | 2006-11-10 | 2007-11-09 | Methods for the treatment of abeta related disorders and compositions therefor |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008057599A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2461673A4 (en) | 2009-08-05 | 2013-08-07 | Intra Cellular Therapies Inc | Novel regulatory proteins and inhibitors |
NZ704666A (en) | 2012-08-23 | 2018-05-25 | Alios Biopharma Inc | Compounds for the treatment of paramoxyvirus viral infections |
CN105030776A (en) * | 2015-06-24 | 2015-11-11 | 北京键凯科技有限公司 | Application of Src protein inhibitor to preparation of medicine used for preventing and/or treating Alzheimer's disease |
WO2023059867A1 (en) * | 2021-10-08 | 2023-04-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compounds for treating or preventing alzheimer's disease |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080103107A1 (en) * | 2004-06-21 | 2008-05-01 | Malcolm Ward | Screening Methods |
-
2007
- 2007-11-09 WO PCT/US2007/023663 patent/WO2008057599A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080103107A1 (en) * | 2004-06-21 | 2008-05-01 | Malcolm Ward | Screening Methods |
Non-Patent Citations (2)
Title |
---|
MCDONALD D.R.: "Amyloid Fibrils Activate Tyrosine Kinase-dependent signaling and Superoxide Production in Microglia", THE JOURNAL OF NEUROSCIENCE, vol. 17, no. 7, 1 April 1997 (1997-04-01), pages 2284 - 2294, XP002669072 * |
NAM S.: "Action of the Src Family Kinase Inhibitor, Dasatinib (BMS-354825), on Human Prostate Cancer Cells", CANCER RESEARCH, vol. 65, no. 20, 2005, pages 9185 - 9189, XP002425076 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008057599A2 (en) | 2008-05-15 |
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