WO2008053478A3 - Compositions and methods for inhibiting hiv-1 replication and integrase activity - Google Patents

Compositions and methods for inhibiting hiv-1 replication and integrase activity Download PDF

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Publication number
WO2008053478A3
WO2008053478A3 PCT/IL2007/001321 IL2007001321W WO2008053478A3 WO 2008053478 A3 WO2008053478 A3 WO 2008053478A3 IL 2007001321 W IL2007001321 W IL 2007001321W WO 2008053478 A3 WO2008053478 A3 WO 2008053478A3
Authority
WO
WIPO (PCT)
Prior art keywords
replication
compositions
methods
inhibiting hiv
integrase activity
Prior art date
Application number
PCT/IL2007/001321
Other languages
French (fr)
Other versions
WO2008053478A2 (en
Inventor
Assaf Friedler
Abraham Loyter
Moshe Kotler
Amnon Hizi
Zvi Hayouka
Joseph Rosenbluh
Aviad Levin
Shoshana Loya
Original Assignee
Yissum Res Dev Co
Univ Ramot
Assaf Friedler
Abraham Loyter
Moshe Kotler
Amnon Hizi
Zvi Hayouka
Joseph Rosenbluh
Aviad Levin
Shoshana Loya
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co, Univ Ramot, Assaf Friedler, Abraham Loyter, Moshe Kotler, Amnon Hizi, Zvi Hayouka, Joseph Rosenbluh, Aviad Levin, Shoshana Loya filed Critical Yissum Res Dev Co
Publication of WO2008053478A2 publication Critical patent/WO2008053478A2/en
Publication of WO2008053478A3 publication Critical patent/WO2008053478A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides isolated peptides comprising a fragment of a LEDGF/p75 protein and use of same for treating HIV-1 infection, inhibiting HIV-1 replication and inhibiting DNA binding and 3'-end processing activity of HIV-1 integrase protein.
PCT/IL2007/001321 2006-10-30 2007-10-30 Compositions and methods for inhibiting hiv-1 replication and integrase activity WO2008053478A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85513006P 2006-10-30 2006-10-30
US60/855,130 2006-10-30

Publications (2)

Publication Number Publication Date
WO2008053478A2 WO2008053478A2 (en) 2008-05-08
WO2008053478A3 true WO2008053478A3 (en) 2008-07-03

Family

ID=39137007

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2007/001321 WO2008053478A2 (en) 2006-10-30 2007-10-30 Compositions and methods for inhibiting hiv-1 replication and integrase activity

Country Status (1)

Country Link
WO (1) WO2008053478A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
ES2574988T3 (en) 2008-10-06 2016-06-23 Yissum Research Development Company Of The Herbrew University Of Jerusalem Ltd. Peptides derived from HIV-1 integrase stimulants that interfere with the Rev-integrase protein
EP2588455B1 (en) 2010-07-02 2018-04-04 Gilead Sciences, Inc. 2-quinolinyl-acetic acid derivatives as hiv antiviral compounds
MA34397B1 (en) 2010-07-02 2013-07-03 Gilead Sciences Inc NAPHTH-2-YLACETIC ACID DERIVATIVES IN AIDS TREATMENT
UA111841C2 (en) 2011-04-21 2016-06-24 Гіліад Сайєнсіз, Інк. BENZOTHIAZOL COMPOUNDS AND THEIR PHARMACEUTICAL APPLICATION
US9284323B2 (en) 2012-01-04 2016-03-15 Gilead Sciences, Inc. Naphthalene acetic acid derivatives against HIV infection
US9376392B2 (en) 2012-01-04 2016-06-28 Gilead Sciences, Inc. 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS
PE20141558A1 (en) 2012-04-20 2014-11-06 Gilead Sciences Inc DERIVATIVES OF BENZOTHIAZOLE-6-IL ACETIC ACID AND THEIR USE TO TREAT HIV INFECTION
BR112014028951A8 (en) * 2012-05-21 2021-09-14 Univ Colorado Regents Ledgf peptides, their use, composition, nucleic acid sequence, and vector

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHEREPANOV PETER ET AL.: "Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 47, 19 November 2004 (2004-11-19), pages 48883 - 48892, XP002478701, ISSN: 0021-9258 *
CHEREPANOV PETER ET AL.: "Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, no. 48, November 2005 (2005-11-01), pages 17308 - 17313, XP002478700, ISSN: 0027-8424 *
DATABASE PDB [online] 24 September 2005 (2005-09-24), CHEREPANOV P., AMBROSIO A.L., RAHMAN S., ELLENBERGER T., ENGELMAN A.: "Structural basis for the recognition between HIV-1 integrase and LEDGF/p75", XP002478702, retrieved from EBI accession no. PDB:2B4J Database accession no. 2B4J *
DE RIJCK JAN ET AL.: "Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication", 20 September 2006 (2006-09-20), XP002478856, Retrieved from the Internet <URL:http://jvi.asm.org/cgi/reprint/JVI.00801-06v1> [retrieved on 20080430] *
HAYOUKA ZVI ET AL.: "Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium", PNAS, vol. 104, no. 20, 15 May 2007 (2007-05-15), pages 8316 - 8321, XP002478699 *
LATAILLADE MAX ET AL.: "The hunt for HIV-1 integrase inhibitors.", AIDS PATIENT CARE AND STDS JUL 2006, vol. 20, no. 7, July 2006 (2006-07-01), pages 489 - 501, XP009099694, ISSN: 1087-2914 *

Also Published As

Publication number Publication date
WO2008053478A2 (en) 2008-05-08

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