WO2008051511A3 - Polymorphismes génétiques associés à la thrombose veineuse, procédés pour les détecter et utilisations - Google Patents

Polymorphismes génétiques associés à la thrombose veineuse, procédés pour les détecter et utilisations Download PDF

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Publication number
WO2008051511A3
WO2008051511A3 PCT/US2007/022414 US2007022414W WO2008051511A3 WO 2008051511 A3 WO2008051511 A3 WO 2008051511A3 US 2007022414 W US2007022414 W US 2007022414W WO 2008051511 A3 WO2008051511 A3 WO 2008051511A3
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WO
WIPO (PCT)
Prior art keywords
methods
detection
nucleic acid
genetic polymorphisms
venous thrombosis
Prior art date
Application number
PCT/US2007/022414
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English (en)
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WO2008051511A2 (fr
Inventor
Lance Bare
Original Assignee
Applera Corp
Lance Bare
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applera Corp, Lance Bare filed Critical Applera Corp
Priority to EP07861475A priority Critical patent/EP2084297A4/fr
Priority to CA2666346A priority patent/CA2666346C/fr
Publication of WO2008051511A2 publication Critical patent/WO2008051511A2/fr
Publication of WO2008051511A3 publication Critical patent/WO2008051511A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention est fondée sur la découverte de polymorphismes génétiques associés à la maladie coronarienne, en particulier la thrombose veineuse, ainsi que sur la réponse au traitement médicamenteux. L'invention concerne en particulier des molécules d'acide nucléique contenant lesdits polymorphismes, des variantes de protéines codées par lesdites molécules d'acide nucléique, des réactifs destinés à détecter les molécules d'acides nucléiques polymorphes et les protéines, ainsi que des procédés utilisant l'acide nucléique et les protéines et des procédés utilisant des réactifs pour les détecter.
PCT/US2007/022414 2006-10-20 2007-10-19 Polymorphismes génétiques associés à la thrombose veineuse, procédés pour les détecter et utilisations WO2008051511A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07861475A EP2084297A4 (fr) 2006-10-20 2007-10-19 Polymorphismes génétiques associés à la thrombose veineuse, procédés pour les détecter et utilisations
CA2666346A CA2666346C (fr) 2006-10-20 2007-10-19 Polymorphismes genetiques associes a la thrombose veineuse, procedes pour les detecter et utilisations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85328406P 2006-10-20 2006-10-20
US60/853,284 2006-10-20

Publications (2)

Publication Number Publication Date
WO2008051511A2 WO2008051511A2 (fr) 2008-05-02
WO2008051511A3 true WO2008051511A3 (fr) 2008-10-30

Family

ID=39325148

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/022414 WO2008051511A2 (fr) 2006-10-20 2007-10-19 Polymorphismes génétiques associés à la thrombose veineuse, procédés pour les détecter et utilisations

Country Status (4)

Country Link
US (4) US7910303B2 (fr)
EP (2) EP2084297A4 (fr)
CA (2) CA2915679C (fr)
WO (1) WO2008051511A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110282043A1 (en) * 2010-03-12 2011-11-17 Cenetron Diagnostics Llc Methods and compositions comprising nucleic acid polymerization enhancers
US20120108651A1 (en) * 2010-11-02 2012-05-03 Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
US20140309139A1 (en) * 2011-10-07 2014-10-16 Rainer Bernd Zotz Genetic polymorphisms associated with venous thrombosis in women, methods of detection and uses thereof
EP2578698A1 (fr) 2011-10-07 2013-04-10 Rüdiger Eberhard Scharf Polymorphismes génétiques associés à la thrombose veineuse chez les femmes, procédés de détection et utilisations associées
DE102016212003A1 (de) 2016-07-01 2018-01-04 Volkswagen Aktiengesellschaft Kurzschlussläufer
CA3046150A1 (fr) * 2016-12-09 2018-06-14 Gene Predictis Sa Procede pour la prediction du risque de thrombose veineuse profonde et d'embolie pulmonaire associee a des preparations hormonales et a des niveaux hormonaux
JP2022523564A (ja) 2019-03-04 2022-04-25 アイオーカレンツ， インコーポレイテッド 機械学習を使用するデータ圧縮および通信

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Also Published As

Publication number Publication date
EP2431483B1 (fr) 2015-04-01
EP2084297A4 (fr) 2010-10-20
US8227189B2 (en) 2012-07-24
US20090258003A1 (en) 2009-10-15
CA2666346C (fr) 2016-02-23
US20130045198A1 (en) 2013-02-21
CA2915679A1 (fr) 2008-05-02
WO2008051511A2 (fr) 2008-05-02
US7910303B2 (en) 2011-03-22
EP2084297A2 (fr) 2009-08-05
US20120039864A1 (en) 2012-02-16
US20140186333A1 (en) 2014-07-03
CA2915679C (fr) 2017-12-12
CA2666346A1 (fr) 2008-05-02
EP2431483A1 (fr) 2012-03-21

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