WO2008048272A3 - Method of drug delivery by carbon nanotube-chitosan nanocomplexes - Google Patents

Method of drug delivery by carbon nanotube-chitosan nanocomplexes Download PDF

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Publication number
WO2008048272A3
WO2008048272A3 PCT/US2006/041570 US2006041570W WO2008048272A3 WO 2008048272 A3 WO2008048272 A3 WO 2008048272A3 US 2006041570 W US2006041570 W US 2006041570W WO 2008048272 A3 WO2008048272 A3 WO 2008048272A3
Authority
WO
WIPO (PCT)
Prior art keywords
chitosan
carbon nanotube
peptide
delivery
swcnt
Prior art date
Application number
PCT/US2006/041570
Other languages
French (fr)
Other versions
WO2008048272A9 (en
WO2008048272A2 (en
Inventor
Shyam S Mohapatra
Arun Kumar
Original Assignee
Univ South Florida
Shyam S Mohapatra
Arun Kumar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ South Florida, Shyam S Mohapatra, Arun Kumar filed Critical Univ South Florida
Priority to US12/105,884 priority Critical patent/US8536324B2/en
Publication of WO2008048272A2 publication Critical patent/WO2008048272A2/en
Publication of WO2008048272A9 publication Critical patent/WO2008048272A9/en
Publication of WO2008048272A3 publication Critical patent/WO2008048272A3/en
Priority to US13/965,527 priority patent/US20140023588A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric

Abstract

Functionalized Single Wall Carbon Nanotube (SWCNT) complexed with nanochitosan for use in the delivery of bioaffecting substances and diagnostic applications. fSWCNT complexed with the chitosan NG042 were used for delivery of DNA-encoding EGFP reporter protein and peptide. The results demonstrate that shown CNT-chitosan hybrid nanoparticles exhibit significantly higher transfection efficiency in vivo than chitosan alone. Furthermore, the functionalized nanotubes were tested for peptide transfer into HEK293 cells. The results showed that the hybrid nanoparticles efficiently transferred peptides. Together, these results show that hybrid SWCNT-chitosan particles increase DNA and peptide transfer into cells.
PCT/US2006/041570 2005-10-21 2006-10-23 Method of drug delivery by carbon nanotube-chitosan nanocomplexes WO2008048272A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/105,884 US8536324B2 (en) 2005-10-21 2008-04-18 Method of drug delivery by carbon nanotube-chitosan nanocomplexes
US13/965,527 US20140023588A1 (en) 2005-10-21 2013-08-13 Method of drug delivery by carbon nanotube chitosan nanocomplexes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72946106P 2006-10-21 2006-10-21
US60/729,461 2006-10-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/105,884 Continuation US8536324B2 (en) 2005-10-21 2008-04-18 Method of drug delivery by carbon nanotube-chitosan nanocomplexes

Publications (3)

Publication Number Publication Date
WO2008048272A2 WO2008048272A2 (en) 2008-04-24
WO2008048272A9 WO2008048272A9 (en) 2008-06-26
WO2008048272A3 true WO2008048272A3 (en) 2008-12-24

Family

ID=39314526

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/041570 WO2008048272A2 (en) 2005-10-21 2006-10-23 Method of drug delivery by carbon nanotube-chitosan nanocomplexes

Country Status (1)

Country Link
WO (1) WO2008048272A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009006606A1 (en) * 2009-01-29 2010-08-05 Philipps-Universität Marburg Non-viral transfection agent
CN101726521B (en) * 2009-12-01 2012-07-04 暨南大学 Biosensor for rapidly detecting sterigmatocystin and assembling method thereof
CN106633128B (en) * 2016-10-21 2022-04-01 皖西学院 Preparation method of chitosan film and chitosan film

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050037374A1 (en) * 1999-11-08 2005-02-17 Melker Richard J. Combined nanotechnology and sensor technologies for simultaneous diagnosis and treatment
US20060134220A1 (en) * 2002-06-20 2006-06-22 Bioalliance Pharma Vectorization system comprising nanoparticles of homogenous size of at least one polymer and at least one positively charged polysaccharide and method for the preparation thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050037374A1 (en) * 1999-11-08 2005-02-17 Melker Richard J. Combined nanotechnology and sensor technologies for simultaneous diagnosis and treatment
US20060134220A1 (en) * 2002-06-20 2006-06-22 Bioalliance Pharma Vectorization system comprising nanoparticles of homogenous size of at least one polymer and at least one positively charged polysaccharide and method for the preparation thereof

Also Published As

Publication number Publication date
WO2008048272A9 (en) 2008-06-26
WO2008048272A2 (en) 2008-04-24

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