WO2008044246A3 - A process for the preparation of warfarin sodium - Google Patents

A process for the preparation of warfarin sodium Download PDF

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Publication number
WO2008044246A3
WO2008044246A3 PCT/IN2007/000471 IN2007000471W WO2008044246A3 WO 2008044246 A3 WO2008044246 A3 WO 2008044246A3 IN 2007000471 W IN2007000471 W IN 2007000471W WO 2008044246 A3 WO2008044246 A3 WO 2008044246A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
warfarin sodium
solvate
warfarin
methods
Prior art date
Application number
PCT/IN2007/000471
Other languages
French (fr)
Other versions
WO2008044246A2 (en
Inventor
Nageswara Rao Karusala
Jayrambhai Ahir Kishore
Mohan Bandari
Seeta Ramanjaneyulu Gorantla
Original Assignee
Matrix Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Ltd filed Critical Matrix Laboratories Ltd
Publication of WO2008044246A2 publication Critical patent/WO2008044246A2/en
Publication of WO2008044246A3 publication Critical patent/WO2008044246A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Provided are novel solvates of Warfarin sodium namely Acetone- ethyl acetate solvate, ethyl acetate solvate, Ethanol-Heptane solvate, Acetone-Heptane solvate and methods for their preparation. Also provided are methods for making Warfarin sodium from Warfarin via the novel solvates.
PCT/IN2007/000471 2006-10-10 2007-10-09 A process for the preparation of warfarin sodium WO2008044246A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1871/CHE/2006 2006-10-10
IN1871CH2006 2006-10-10

Publications (2)

Publication Number Publication Date
WO2008044246A2 WO2008044246A2 (en) 2008-04-17
WO2008044246A3 true WO2008044246A3 (en) 2009-09-24

Family

ID=39283275

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000471 WO2008044246A2 (en) 2006-10-10 2007-10-09 A process for the preparation of warfarin sodium

Country Status (1)

Country Link
WO (1) WO2008044246A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2777859A (en) * 1953-02-05 1957-01-15 Wisconsin Alumni Res Found Warfarin-alkali metal derivatives and processes of preparing the same
US3077481A (en) * 1961-02-21 1963-02-12 Wisconsin Alumni Res Found Warfarin sodium
US3192232A (en) * 1961-02-21 1965-06-29 Wisconsin Alumni Res Found Warfarin alkali metal derivative process
WO2002070504A1 (en) * 2001-02-28 2002-09-12 Taro Pharmaceuticals U.S.A., Inc. Preparation of warfarin sodium from warfarin sodium-2-propanol clathrate by solvent expulsion
US6673944B2 (en) * 2001-02-28 2004-01-06 Taro Pharmaceutical Industries, Ltd. Preparation of warfarin sodium from warfarin acid

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2777859A (en) * 1953-02-05 1957-01-15 Wisconsin Alumni Res Found Warfarin-alkali metal derivatives and processes of preparing the same
US3077481A (en) * 1961-02-21 1963-02-12 Wisconsin Alumni Res Found Warfarin sodium
US3192232A (en) * 1961-02-21 1965-06-29 Wisconsin Alumni Res Found Warfarin alkali metal derivative process
WO2002070504A1 (en) * 2001-02-28 2002-09-12 Taro Pharmaceuticals U.S.A., Inc. Preparation of warfarin sodium from warfarin sodium-2-propanol clathrate by solvent expulsion
US6673944B2 (en) * 2001-02-28 2004-01-06 Taro Pharmaceutical Industries, Ltd. Preparation of warfarin sodium from warfarin acid

Also Published As

Publication number Publication date
WO2008044246A2 (en) 2008-04-17

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