WO2008042422A3 - Bicyclic and tricyclic derivatives as thrombin receptor antagonists - Google Patents
Bicyclic and tricyclic derivatives as thrombin receptor antagonists Download PDFInfo
- Publication number
- WO2008042422A3 WO2008042422A3 PCT/US2007/021277 US2007021277W WO2008042422A3 WO 2008042422 A3 WO2008042422 A3 WO 2008042422A3 US 2007021277 W US2007021277 W US 2007021277W WO 2008042422 A3 WO2008042422 A3 WO 2008042422A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bond
- bicyclic
- receptor antagonists
- thrombin receptor
- tricyclic derivatives
- Prior art date
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Diabetes (AREA)
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Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2009003761A MX2009003761A (en) | 2006-10-04 | 2007-10-02 | Bicyclic and tricyclic derivatives as thrombin receptor antagonists. |
EP07867202.9A EP2069326B1 (en) | 2006-10-04 | 2007-10-02 | Bicyclic and tricyclic derivatives as thrombin receptor antagonists |
JP2009531448A JP2010505842A (en) | 2006-10-04 | 2007-10-02 | Bicyclic and tricyclic derivatives as thrombin receptor antagonists |
AU2007305269A AU2007305269A1 (en) | 2006-10-04 | 2007-10-02 | Bicyclic and tricyclic derivatives as thrombin receptor antagonists |
CA002667082A CA2667082A1 (en) | 2006-10-04 | 2007-10-02 | Bicyclic and tricyclic derivatives as thrombin receptor antagonists |
IL198009A IL198009A0 (en) | 2006-10-04 | 2009-04-05 | Bicyclic and tricyclic derivatives as thrombin receptor antagonists |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84935406P | 2006-10-04 | 2006-10-04 | |
US60/849,354 | 2006-10-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008042422A2 WO2008042422A2 (en) | 2008-04-10 |
WO2008042422A3 true WO2008042422A3 (en) | 2009-03-26 |
Family
ID=39269039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/021277 WO2008042422A2 (en) | 2006-10-04 | 2007-10-02 | Bicyclic and tricyclic derivatives as thrombin receptor antagonists |
Country Status (13)
Country | Link |
---|---|
US (2) | US8153664B2 (en) |
EP (1) | EP2069326B1 (en) |
JP (1) | JP2010505842A (en) |
KR (1) | KR20090074219A (en) |
CN (1) | CN101541782A (en) |
AR (1) | AR063123A1 (en) |
AU (1) | AU2007305269A1 (en) |
CA (1) | CA2667082A1 (en) |
IL (1) | IL198009A0 (en) |
MX (1) | MX2009003761A (en) |
TW (1) | TW200823205A (en) |
WO (1) | WO2008042422A2 (en) |
ZA (1) | ZA200902362B (en) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8227412B2 (en) * | 2007-03-29 | 2012-07-24 | Tsopanoglou Nikos E | Bioactive parstatin peptides and methods of use |
JP5512534B2 (en) * | 2007-12-07 | 2014-06-04 | アンセルム(アンスチチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル) | Methods for treatment and diagnosis of bone mineral density related disorders |
PT2438060E (en) * | 2009-06-04 | 2013-12-16 | Merck Sharp & Dohme | Active metabolite of a thrombin receptor antagonist |
NZ600008A (en) | 2009-12-04 | 2014-10-31 | Sunovion Pharmaceuticals Inc | Multicyclic compounds and methods of use thereof |
WO2011128421A1 (en) | 2010-04-16 | 2011-10-20 | Sanofi | Tricyclic pyridyl-vinyl pyrroles as par1 inhibitors |
PL2558462T3 (en) | 2010-04-16 | 2015-03-31 | Sanofi Sa | Pyridyl-vinyl-pyrazolo-chinolines as PAR1 inhibitors |
WO2013134012A1 (en) | 2012-03-06 | 2013-09-12 | Merck Sharp & Dohme Corp. | Preparation and use of bicyclic himbacine derivatives as par-receptor antagonists |
WO2015026685A1 (en) | 2013-08-22 | 2015-02-26 | Merck Sharp & Dohme Corp. | 7a-heterocycle substituted- 6, 6-difluoro bicyclic himbacine derivatives |
US9701669B2 (en) | 2013-08-22 | 2017-07-11 | Merck Sharp & Dohme Corp. | Preparation and use of 7a-amide substituted- 6,6-difluoro bicyclic himbacine derivatives as PAR-1 receptor antagonists |
US9808473B2 (en) | 2013-08-22 | 2017-11-07 | Merck Sharp & Dohme Corp. | Preparation and use of 3-pyridyl substituted-6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists |
WO2016060940A1 (en) * | 2014-10-15 | 2016-04-21 | Merck Sharp & Dohme Corp. | Preparation and use of cyclic sulfonamide derivatives as par-1 receptor antagonists |
WO2016058144A1 (en) * | 2014-10-15 | 2016-04-21 | Merck Sharp & Dohme Corp. | Preparation and use of cyclic sulfonamide derivatives as par-1 receptor antagonists |
CN105985303B (en) * | 2015-02-13 | 2020-08-14 | 上海彩迩文生化科技有限公司 | Preparation method of anticoagulant, intermediate and preparation method thereof |
CN105732595B (en) * | 2015-12-22 | 2018-08-28 | 山东大学 | PAR-1 inhibitor based on terpene derivant and preparation method thereof and the purposes in treating thrombotic diseases |
CN107129477A (en) * | 2016-02-26 | 2017-09-05 | 上海星泰医药科技有限公司 | The preparation method of (dihydronaphthalene [the 2,3-c] -6- furyls of (1R, 3aR, 4aR, 6R, 8aR, 9S, 9aR) -9- formoxyl -1- methyl -3- oxa-s ten) carboxylic acid, ethyl ester |
BR112019001407A2 (en) | 2016-07-29 | 2019-07-09 | Pgi Drug Discovery Llc | compounds and compositions and uses thereof |
US10196403B2 (en) | 2016-07-29 | 2019-02-05 | Sunovion Pharmaceuticals Inc. | Compounds and compositions and uses thereof |
CA3053903A1 (en) | 2017-02-16 | 2018-08-23 | Sunovion Pharmaceuticals Inc. | Methods of treating schizophrenia |
JP7191085B2 (en) | 2017-08-02 | 2022-12-16 | サノビオン ファーマシューティカルズ インク | Isochroman compounds and uses thereof |
JP7453148B2 (en) | 2018-02-16 | 2024-03-19 | サノビオン ファーマシューティカルズ インク | Salts, crystalline forms, and their production methods |
CN110559294A (en) * | 2018-06-06 | 2019-12-13 | 杨仑 | Preventive and therapeutic drug for fatty liver disease and related diseases |
JP2022525169A (en) | 2019-03-14 | 2022-05-11 | サノビオン ファーマシューティカルズ インク | Salts of isochromanyl compounds and crystals thereof, as well as methods for producing them, therapeutic uses and pharmaceutical compositions. |
CN110627710B (en) * | 2019-09-29 | 2020-06-05 | 山东大学 | Novel PAR-1 inhibitor, preparation method thereof and application thereof in preventing and/or treating thrombotic diseases |
CN115734785A (en) | 2020-04-14 | 2023-03-03 | 桑诺维恩药品公司 | (S) - (4, 5-dihydro-7H-thieno [2,3-c ] pyran-7-yl) -N-methylmethanamine for the treatment of neurological and psychiatric disorders |
CN112759548B (en) * | 2020-12-31 | 2021-11-02 | 山东大学 | PAR-1 inhibitor and preparation method thereof |
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Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999026943A1 (en) * | 1997-11-25 | 1999-06-03 | Schering Corporation | Thrombin receptor antagonists |
US6063847A (en) * | 1997-11-25 | 2000-05-16 | Schering Corporation | Thrombin receptor antagonists |
WO2001096330A2 (en) * | 2000-06-15 | 2001-12-20 | Schering Corporation | Thrombin receptor antagonists |
WO2003033501A1 (en) * | 2001-10-18 | 2003-04-24 | Schering Corporation | Himbacine analogues as thrombin receptor antagonists |
JP2003183278A (en) * | 2001-12-25 | 2003-07-03 | Sagami Chem Res Center | Himbacine analog containing aromatic heterocyclic ring |
WO2003089428A1 (en) * | 2002-04-16 | 2003-10-30 | Schering Corporation | Tricyclic thrombin receptor antagonists |
WO2005030712A2 (en) * | 2003-09-25 | 2005-04-07 | Schering Corporation | Thrombin receptor antagonists |
WO2005046688A2 (en) * | 2003-11-10 | 2005-05-26 | Schering Corporation | Methods of use of thrombin receptor antagonists |
WO2006041872A2 (en) * | 2004-10-08 | 2006-04-20 | Schering Corporation | Thrombin receptor antagonists |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1201061A (en) * | 1966-08-26 | 1970-08-05 | Endo Lab | Oxo pyrroles and process for preparing same |
IL106197A (en) | 1992-07-30 | 1999-11-30 | Cor Therapeutics Inc | Thrombin receptor antagonists and pharmaceutical compositions comprising them |
US5874382A (en) * | 1996-11-13 | 1999-02-23 | E. I. Du Pont De Nemours And Company | Cyclic sulfonamide herbicides |
US20030185830A1 (en) * | 1997-02-25 | 2003-10-02 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
FR2807040B1 (en) * | 2000-03-31 | 2002-05-17 | Oreal | PROCESS FOR THE PREPARATION OF 3- (4-HYDROXY-1H-INDOL-5- YLMETHYL) -PYRIDINIUMS COMPOUNDS USING AN ALDOLIZATION REACTION |
AU2004270394A1 (en) * | 2003-09-10 | 2005-03-17 | Gpc Biotech Ag | Heterobicyclic compounds as pharmaceutically active agents |
CN1890224B (en) * | 2003-12-05 | 2011-06-08 | 詹森药业有限公司 | 6-substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose)polymerase inhibitors |
BRPI0510410A (en) * | 2004-05-28 | 2007-10-23 | Speedel Experimenta Ag | organic compounds |
US7429666B2 (en) * | 2004-06-10 | 2008-09-30 | Merck Frosst Canada Ltd. | Pyridine analogs as C5a antagonists |
KR101099292B1 (en) * | 2004-07-29 | 2011-12-26 | 가부시키가이샤 아데카 | Optical recording material and optical recording medium |
CA2582674A1 (en) * | 2004-10-04 | 2006-04-20 | Myriad Genetics, Inc. | Compounds for alzheimer's disease |
JP4705367B2 (en) * | 2004-12-24 | 2011-06-22 | 花王株式会社 | Hair dye composition |
CN101163681A (en) * | 2005-04-21 | 2008-04-16 | 日本新药株式会社 | Phthalazinone derivative and pharmaceutical comprising the same |
DE102005049953A1 (en) * | 2005-10-19 | 2007-04-26 | Sanofi-Aventis Deutschland Gmbh | Carbamoylbenzotriazole derivatives as inhibitors of lipases and phospholipases |
AU2007234399A1 (en) * | 2006-04-04 | 2007-10-11 | Myriad Genetics, Inc. | Compounds for diseases and disorders |
JP5236628B2 (en) * | 2006-04-21 | 2013-07-17 | イーライ リリー アンド カンパニー | Cyclohexylimidazole lactam derivatives as 11-β-hydroxysteroid dehydrogenase 1 inhibitors |
AR061664A1 (en) * | 2006-06-29 | 2008-09-10 | Schering Corp | DERIVATIVES OF HIMBACINE AS ANTAGONISTS OF THE SUBSTITUTED BICYCLE AND TRICICLIC THROMBINE RECEPTOR. PHARMACEUTICAL COMPOSITIONS. |
EP2109364A4 (en) * | 2006-12-15 | 2010-04-14 | Abbott Lab | Novel oxadiazole compounds |
-
2007
- 2007-10-02 WO PCT/US2007/021277 patent/WO2008042422A2/en active Application Filing
- 2007-10-02 CN CNA2007800433716A patent/CN101541782A/en active Pending
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-
2009
- 2009-04-03 ZA ZA200902362A patent/ZA200902362B/en unknown
- 2009-04-05 IL IL198009A patent/IL198009A0/en unknown
-
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- 2012-02-24 US US13/404,462 patent/US20120157403A1/en not_active Abandoned
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999026943A1 (en) * | 1997-11-25 | 1999-06-03 | Schering Corporation | Thrombin receptor antagonists |
US6063847A (en) * | 1997-11-25 | 2000-05-16 | Schering Corporation | Thrombin receptor antagonists |
WO2001096330A2 (en) * | 2000-06-15 | 2001-12-20 | Schering Corporation | Thrombin receptor antagonists |
WO2003033501A1 (en) * | 2001-10-18 | 2003-04-24 | Schering Corporation | Himbacine analogues as thrombin receptor antagonists |
JP2003183278A (en) * | 2001-12-25 | 2003-07-03 | Sagami Chem Res Center | Himbacine analog containing aromatic heterocyclic ring |
WO2003089428A1 (en) * | 2002-04-16 | 2003-10-30 | Schering Corporation | Tricyclic thrombin receptor antagonists |
WO2005030712A2 (en) * | 2003-09-25 | 2005-04-07 | Schering Corporation | Thrombin receptor antagonists |
WO2005046688A2 (en) * | 2003-11-10 | 2005-05-26 | Schering Corporation | Methods of use of thrombin receptor antagonists |
WO2006041872A2 (en) * | 2004-10-08 | 2006-04-20 | Schering Corporation | Thrombin receptor antagonists |
Non-Patent Citations (9)
Title |
---|
A. RICHARDSON: "The chemisztry of 7-aminoindoline and certain pyrrolo- and pyrido[1,2,3-de]quinoxalines", J. ORG. CHEM., vol. 30, no. 8, 1965, pages 2589 - 2593, XP002512077 * |
CLASBY M C ET AL: "Discovery and synthesis of a novel series of quinoline-based thrombin receptor (PAR-1) antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 16, no. 6, 15 March 2006 (2006-03-15), pages 1544 - 1548, XP025107045, ISSN: 0960-894X, [retrieved on 20060315] * |
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002512078, retrieved from CAPLUS accession no. 1987:636453 * |
IL'YASOV ET AL.: "Homolytic pyridylethylation of cyclohexane and tetralin", ZHURNAL ORGANICHESKOI KHIMII, vol. 23, no. 2, 1987, pages 365 - 369 * |
M. S. MUDADU ET AL.: "7-Pyridylindoles: Synthesis, Structure, and Properties", J. ORG. CHEM., vol. 71, no. 20, 2006, pages 7611 - 7617, XP002512076 * |
SIT S-Y ET AL: "(+)-Dinapsoline: an efficient synthesis and pharmacological profile of a novel dopamine agonist", JOURNAL OF MEDICINAL CHEMISTRY, US AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 45, no. 17, 20 July 2002 (2002-07-20), pages 3660 - 3668, XP002301886, ISSN: 0022-2623 * |
XIA Y ET AL: "Himbacine derived thrombin receptor (PAR-1) antagonists: Structure-activity relationship of the lactone ring", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 16, no. 18, 15 September 2006 (2006-09-15), pages 4969 - 4972, XP025107307, ISSN: 0960-894X, [retrieved on 20060915] * |
XIN WANG ET AL: "A practical synthesis of 2-((1H-pyrrolo[2,3-b]pyridine-4-yl)methylami no)-5-fluoronicotinic acid", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON.; US, vol. 71, no. 10, 1 January 2006 (2006-01-01), pages 4021 - 4023, XP002502662, ISSN: 0022-3263 * |
YOSHIDA Y ET AL: "Discovery of a novel benzyloxyisoquinoline derivative with potent anti-Helicobacter pylori activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 8, no. 14, 21 July 1998 (1998-07-21), pages 1897 - 1902, XP004137152, ISSN: 0960-894X * |
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WO2008042422A2 (en) | 2008-04-10 |
IL198009A0 (en) | 2009-12-24 |
AR063123A1 (en) | 2008-12-30 |
EP2069326A2 (en) | 2009-06-17 |
US20120157403A1 (en) | 2012-06-21 |
CN101541782A (en) | 2009-09-23 |
US20080090830A1 (en) | 2008-04-17 |
MX2009003761A (en) | 2009-06-30 |
CA2667082A1 (en) | 2008-04-10 |
JP2010505842A (en) | 2010-02-25 |
AU2007305269A1 (en) | 2008-04-10 |
KR20090074219A (en) | 2009-07-06 |
TW200823205A (en) | 2008-06-01 |
EP2069326B1 (en) | 2015-03-18 |
US8153664B2 (en) | 2012-04-10 |
ZA200902362B (en) | 2010-10-27 |
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