WO2008038304A3 - Therapeutical formulation comprising an alpha-glucosidase inhibitor and a nitric oxide scavenger. - Google Patents

Therapeutical formulation comprising an alpha-glucosidase inhibitor and a nitric oxide scavenger. Download PDF

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Publication number
WO2008038304A3
WO2008038304A3 PCT/IN2007/000436 IN2007000436W WO2008038304A3 WO 2008038304 A3 WO2008038304 A3 WO 2008038304A3 IN 2007000436 W IN2007000436 W IN 2007000436W WO 2008038304 A3 WO2008038304 A3 WO 2008038304A3
Authority
WO
WIPO (PCT)
Prior art keywords
alpha
nitric oxide
glucosidase inhibitor
oxide scavenger
formulation
Prior art date
Application number
PCT/IN2007/000436
Other languages
French (fr)
Other versions
WO2008038304A2 (en
Inventor
Jegannathan Srinivas
Original Assignee
Jegannathan Srinivas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jegannathan Srinivas filed Critical Jegannathan Srinivas
Publication of WO2008038304A2 publication Critical patent/WO2008038304A2/en
Publication of WO2008038304A3 publication Critical patent/WO2008038304A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A therapeutic formulation comprising of Alphaglucosidase Inhibitors as active agents namely, Acarbose and Miglitol, characterized in that said Alphaglucosidase Inhibitors are combined or complexated with NO Scavenger to prevent Diabetic Complications arising out of Nitrosative stress.
PCT/IN2007/000436 2006-09-26 2007-09-26 Therapeutical formulation comprising an alpha-glucosidase inhibitor and a nitric oxide scavenger. WO2008038304A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1761/CHE/2006 2006-09-26
IN1761CH2006 2006-09-26

Publications (2)

Publication Number Publication Date
WO2008038304A2 WO2008038304A2 (en) 2008-04-03
WO2008038304A3 true WO2008038304A3 (en) 2008-05-22

Family

ID=39230688

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000436 WO2008038304A2 (en) 2006-09-26 2007-09-26 Therapeutical formulation comprising an alpha-glucosidase inhibitor and a nitric oxide scavenger.

Country Status (1)

Country Link
WO (1) WO2008038304A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013115742A1 (en) * 2012-01-31 2013-08-08 Mahmut Bilgic Pharmaceutical composition comprising alpha-glucosidase inhibitor

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998011066A1 (en) * 1996-09-10 1998-03-19 Medinox, Inc. Polydithiocarbamate-containing macromolecules and the use thereof for therapeutic and diagnostic applications
WO1998055453A1 (en) * 1997-06-04 1998-12-10 Medinox, Inc. Conjugates of dithiocarbamates with pharmacologically active agents and uses therefor
WO1999066924A1 (en) * 1998-06-23 1999-12-29 Medinox, Inc. Use of nitric oxide scavengers to treat side effects caused by therapeutic administration of sources of nitric oxide
US20020151540A1 (en) * 2000-05-05 2002-10-17 Medinox, Inc. Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor
WO2005027981A1 (en) * 2003-09-17 2005-03-31 Board Of Regents, The University Of Texas System Mechanism-based targeted pancreatic beta cell imaging and therapy

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998011066A1 (en) * 1996-09-10 1998-03-19 Medinox, Inc. Polydithiocarbamate-containing macromolecules and the use thereof for therapeutic and diagnostic applications
WO1998055453A1 (en) * 1997-06-04 1998-12-10 Medinox, Inc. Conjugates of dithiocarbamates with pharmacologically active agents and uses therefor
WO1999066924A1 (en) * 1998-06-23 1999-12-29 Medinox, Inc. Use of nitric oxide scavengers to treat side effects caused by therapeutic administration of sources of nitric oxide
US20020151540A1 (en) * 2000-05-05 2002-10-17 Medinox, Inc. Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor
WO2005027981A1 (en) * 2003-09-17 2005-03-31 Board Of Regents, The University Of Texas System Mechanism-based targeted pancreatic beta cell imaging and therapy

Also Published As

Publication number Publication date
WO2008038304A2 (en) 2008-04-03

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