WO2008035378A3 - An improved process for the preparation of thalidomide - Google Patents
An improved process for the preparation of thalidomide Download PDFInfo
- Publication number
- WO2008035378A3 WO2008035378A3 PCT/IN2007/000413 IN2007000413W WO2008035378A3 WO 2008035378 A3 WO2008035378 A3 WO 2008035378A3 IN 2007000413 W IN2007000413 W IN 2007000413W WO 2008035378 A3 WO2008035378 A3 WO 2008035378A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- thalidomide
- preparation
- improved process
- carbonyldi
- phthaloyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
An improved process for the preparation of Thalidomide a TNF-alpha inhibitor by the conversion of N-phthaloyl L-glutamine in presence of an active ingredient of inorganic acid salts such as 1,1-Carbonyldi(1,2,4-triazole) as a condensing agent.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1716/CHE/2006 | 2006-09-20 | ||
IN1716CH2006 | 2006-09-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008035378A2 WO2008035378A2 (en) | 2008-03-27 |
WO2008035378A3 true WO2008035378A3 (en) | 2009-09-24 |
Family
ID=39200978
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2007/000413 WO2008035378A2 (en) | 2006-09-20 | 2007-09-13 | An improved process for the preparation of thalidomide |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008035378A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102260241A (en) * | 2010-05-26 | 2011-11-30 | 重庆医药工业研究院有限责任公司 | Industrial preparation method of thalidomide of crystal form alpha |
JP2013528206A (en) * | 2010-06-09 | 2013-07-08 | ジェネリクス・[ユーケー]・リミテッド | Crystalline form of thalidomide and process for its preparation |
CN102924432A (en) * | 2012-11-09 | 2013-02-13 | 常州制药厂有限公司 | Preparation method of high-purity thalidomide |
CN114890988A (en) * | 2022-04-28 | 2022-08-12 | 浙江工业大学 | Chemical synthesis method of thalidomide |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1602654A1 (en) * | 2004-06-01 | 2005-12-07 | Antibioticos S.p.A. | Process for the synthesis of thalidomide |
-
2007
- 2007-09-13 WO PCT/IN2007/000413 patent/WO2008035378A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1602654A1 (en) * | 2004-06-01 | 2005-12-07 | Antibioticos S.p.A. | Process for the synthesis of thalidomide |
Also Published As
Publication number | Publication date |
---|---|
WO2008035378A2 (en) | 2008-03-27 |
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