WO2008035378A3 - An improved process for the preparation of thalidomide - Google Patents

An improved process for the preparation of thalidomide Download PDF

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Publication number
WO2008035378A3
WO2008035378A3 PCT/IN2007/000413 IN2007000413W WO2008035378A3 WO 2008035378 A3 WO2008035378 A3 WO 2008035378A3 IN 2007000413 W IN2007000413 W IN 2007000413W WO 2008035378 A3 WO2008035378 A3 WO 2008035378A3
Authority
WO
WIPO (PCT)
Prior art keywords
thalidomide
preparation
improved process
carbonyldi
phthaloyl
Prior art date
Application number
PCT/IN2007/000413
Other languages
French (fr)
Other versions
WO2008035378A2 (en
Inventor
Purna Chandra Ray
Jagan Mohana Chary Tummanepally
Jebaraj Rathinapandian
Om Dutt Tyagi
Original Assignee
Matrix Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Ltd filed Critical Matrix Laboratories Ltd
Publication of WO2008035378A2 publication Critical patent/WO2008035378A2/en
Publication of WO2008035378A3 publication Critical patent/WO2008035378A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

An improved process for the preparation of Thalidomide a TNF-alpha inhibitor by the conversion of N-phthaloyl L-glutamine in presence of an active ingredient of inorganic acid salts such as 1,1-Carbonyldi(1,2,4-triazole) as a condensing agent.
PCT/IN2007/000413 2006-09-20 2007-09-13 An improved process for the preparation of thalidomide WO2008035378A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1716/CHE/2006 2006-09-20
IN1716CH2006 2006-09-20

Publications (2)

Publication Number Publication Date
WO2008035378A2 WO2008035378A2 (en) 2008-03-27
WO2008035378A3 true WO2008035378A3 (en) 2009-09-24

Family

ID=39200978

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000413 WO2008035378A2 (en) 2006-09-20 2007-09-13 An improved process for the preparation of thalidomide

Country Status (1)

Country Link
WO (1) WO2008035378A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102260241A (en) * 2010-05-26 2011-11-30 重庆医药工业研究院有限责任公司 Industrial preparation method of thalidomide of crystal form alpha
JP2013528206A (en) * 2010-06-09 2013-07-08 ジェネリクス・［ユーケー］・リミテッド Crystalline form of thalidomide and process for its preparation
CN102924432A (en) * 2012-11-09 2013-02-13 常州制药厂有限公司 Preparation method of high-purity thalidomide
CN114890988A (en) * 2022-04-28 2022-08-12 浙江工业大学 Chemical synthesis method of thalidomide

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1602654A1 (en) * 2004-06-01 2005-12-07 Antibioticos S.p.A. Process for the synthesis of thalidomide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1602654A1 (en) * 2004-06-01 2005-12-07 Antibioticos S.p.A. Process for the synthesis of thalidomide

Also Published As

Publication number Publication date
WO2008035378A2 (en) 2008-03-27

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