WO2008034202A3 - Traitement de la sclérose latérale amyotrophique - Google Patents

Traitement de la sclérose latérale amyotrophique Download PDF

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Publication number
WO2008034202A3
WO2008034202A3 PCT/BE2007/000107 BE2007000107W WO2008034202A3 WO 2008034202 A3 WO2008034202 A3 WO 2008034202A3 BE 2007000107 W BE2007000107 W BE 2007000107W WO 2008034202 A3 WO2008034202 A3 WO 2008034202A3
Authority
WO
WIPO (PCT)
Prior art keywords
lateral sclerosis
amyotrophic lateral
ivermectin
derivates
treatment
Prior art date
Application number
PCT/BE2007/000107
Other languages
English (en)
Other versions
WO2008034202A2 (fr
Inventor
Maria Andries
Wim Robberecht
Den Bosch Ludo Van
Original Assignee
Univ Leuven Kath
Maria Andries
Wim Robberecht
Den Bosch Ludo Van
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leuven Kath, Maria Andries, Wim Robberecht, Den Bosch Ludo Van filed Critical Univ Leuven Kath
Publication of WO2008034202A2 publication Critical patent/WO2008034202A2/fr
Publication of WO2008034202A3 publication Critical patent/WO2008034202A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un nouveau médicament pour le traitement médical d'une maladie du neurone moteur (MND) telle que la sclérose latérale amyotrophique. Plus particulièrement, la présente invention concerne l'utilisation de l'ivermectine et d'analogues, pour prévenir, retarder et améliorer une maladie du neurone moteur (MND) telle que la sclérose latérale amyotrophique (ALS) et la dégénérescence associée des neurones moteurs.
PCT/BE2007/000107 2006-09-19 2007-09-19 Traitement de la sclérose latérale amyotrophique WO2008034202A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0618403.0 2006-09-19
GBGB0618403.0A GB0618403D0 (en) 2006-09-19 2006-09-19 Treatment of amyotrophic lateral sclerosis

Publications (2)

Publication Number Publication Date
WO2008034202A2 WO2008034202A2 (fr) 2008-03-27
WO2008034202A3 true WO2008034202A3 (fr) 2008-06-19

Family

ID=37421218

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BE2007/000107 WO2008034202A2 (fr) 2006-09-19 2007-09-19 Traitement de la sclérose latérale amyotrophique

Country Status (2)

Country Link
GB (1) GB0618403D0 (fr)
WO (1) WO2008034202A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9351988B2 (en) 2011-05-02 2016-05-31 Universite De Geneve Macrocyclic lactones and use thereof
CN103356687B (zh) * 2012-10-19 2016-06-01 厦门大学 一种伊维菌素及其衍生物的用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992022302A1 (fr) * 1991-06-07 1992-12-23 Fractal Laboratories, Incorporated Traitement d'affections humaines entrainant un dereglement ou un dysfonctionnement du systeme nerveux
FR2790670A1 (fr) * 1999-03-12 2000-09-15 Aventis Pharma Sa Association riluzole et antagoniste des recepteurs ampa
JP2002047206A (ja) * 2000-07-28 2002-02-12 Taisho Pharmaceut Co Ltd Ｇｄｎｆ産生促進剤、パーキンソン病治療剤およびａｌｓ治療剤
US20060205757A1 (en) * 2005-03-11 2006-09-14 Mingqiang Zhang 39-desmethoxyrapamycin, compositions and methods of use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992022302A1 (fr) * 1991-06-07 1992-12-23 Fractal Laboratories, Incorporated Traitement d'affections humaines entrainant un dereglement ou un dysfonctionnement du systeme nerveux
FR2790670A1 (fr) * 1999-03-12 2000-09-15 Aventis Pharma Sa Association riluzole et antagoniste des recepteurs ampa
JP2002047206A (ja) * 2000-07-28 2002-02-12 Taisho Pharmaceut Co Ltd Ｇｄｎｆ産生促進剤、パーキンソン病治療剤およびａｌｓ治療剤
US20060205757A1 (en) * 2005-03-11 2006-09-14 Mingqiang Zhang 39-desmethoxyrapamycin, compositions and methods of use thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANDRIES ET AL: "Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends the life span of a transgenic mouse model of amyotrophic lateral sclerosis", NEUROBIOLOGY OF DISEASE, BLACKWELL SCIENCE, OXFORD, GB, vol. 25, no. 1, 21 November 2006 (2006-11-21), pages 8 - 16, XP005727015, ISSN: 0969-9961 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TAKI, SHIGEYUKI ET AL: "V-type ATPase inhibitors as GDNF formation promoters for treatment of Parkinson disease and ALS (amyotrophic lateral sclerosis )", XP002474492, retrieved from STN Database accession no. 2002:113136 *

Also Published As

Publication number Publication date
GB0618403D0 (en) 2006-11-01
WO2008034202A2 (fr) 2008-03-27

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