WO2008028057A3 - Shikimic acid-derived compounds for inhibition and detection of aurora a-associated tumors - Google Patents

Shikimic acid-derived compounds for inhibition and detection of aurora a-associated tumors Download PDF

Info

Publication number
WO2008028057A3
WO2008028057A3 PCT/US2007/077266 US2007077266W WO2008028057A3 WO 2008028057 A3 WO2008028057 A3 WO 2008028057A3 US 2007077266 W US2007077266 W US 2007077266W WO 2008028057 A3 WO2008028057 A3 WO 2008028057A3
Authority
WO
WIPO (PCT)
Prior art keywords
aurora
inhibition
detection
shikimic acid
derived compounds
Prior art date
Application number
PCT/US2007/077266
Other languages
French (fr)
Other versions
WO2008028057A2 (en
Inventor
Karl Munger
Hiroyuki Hayakawa
Peter M Howley
Angela N Koehler
Timothy A Lewis
Hua Miao
Stuart L Schreiber
John Tallarico
Original Assignee
Harvard College
Karl Munger
Hiroyuki Hayakawa
Peter M Howley
Angela N Koehler
Timothy A Lewis
Hua Miao
Stuart L Schreiber
John Tallarico
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Karl Munger, Hiroyuki Hayakawa, Peter M Howley, Angela N Koehler, Timothy A Lewis, Hua Miao, Stuart L Schreiber, John Tallarico filed Critical Harvard College
Publication of WO2008028057A2 publication Critical patent/WO2008028057A2/en
Publication of WO2008028057A3 publication Critical patent/WO2008028057A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/12—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 3 and unsubstituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention provides inventive compounds of formulae (I) and (II), pharmaceutically acceptable forms thereof, pharmaceutical compositions thereof, and methods for treatment and their use.
PCT/US2007/077266 2006-08-30 2007-08-30 Shikimic acid-derived compounds for inhibition and detection of aurora a-associated tumors WO2008028057A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84103506P 2006-08-30 2006-08-30
US60/841,035 2006-08-30

Publications (2)

Publication Number Publication Date
WO2008028057A2 WO2008028057A2 (en) 2008-03-06
WO2008028057A3 true WO2008028057A3 (en) 2008-12-18

Family

ID=39136896

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/077266 WO2008028057A2 (en) 2006-08-30 2007-08-30 Shikimic acid-derived compounds for inhibition and detection of aurora a-associated tumors

Country Status (1)

Country Link
WO (1) WO2008028057A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939986B2 (en) * 1999-06-11 2005-09-06 Hoffmann-La Roche Inc. Process for preparing 1,2-diamino compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939986B2 (en) * 1999-06-11 2005-09-06 Hoffmann-La Roche Inc. Process for preparing 1,2-diamino compounds

Also Published As

Publication number Publication date
WO2008028057A2 (en) 2008-03-06

Similar Documents

Publication Publication Date Title
WO2007027527A3 (en) Isoindole-imide compounds and compositions comprising and methods of using the same
IL260127B (en) Mek inhibitors and methods of their use
UA95975C2 (en) N-methylaminomethyl isoindole compounds, compositions comprising thereof and methods of using the same
MX2009003038A (en) 5-substituted quinazolinone derivatives and compositions comprising and methods of using the same.
WO2008156614A3 (en) Imidazopyrazines as protein kinase inhibitors
WO2007095124A3 (en) Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors
WO2008057512A3 (en) Imidazopyrazines as protein kinase inhibitors
WO2008115516A8 (en) 4'-o-substituted isoindoline derivatives and compositions comprising and methods of using the same
WO2008027542A3 (en) 5-substituted isoindoline compounds
WO2006107451A3 (en) Honokiol derivatives for the treatment of proliferative disorders
CL2007002733A1 (en) COMPOUNDS DERIVED FROM 2-ARIL-6-PHENYL-IMIDAZO [1,2-A] PIRIDINES; PROCEDURE FOR OBTAINING COMPOUNDS; PHARMACEUTICAL COMPOSITION; AND USE FOR THE TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES, OSTEOPOROSIS AND CANCER.
WO2009042114A3 (en) Phenazine derivatives and uses thereof
WO2006098761A3 (en) Hsp90 inhibitors, methods of making and uses therefor
WO2006123113A3 (en) Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
WO2008079988A3 (en) Quinazolines for pdk1 inhibition
WO2007106537A3 (en) Aminoquinolones as gsk-3 inhibitors
WO2007019251A3 (en) Sphingosine kinase inhibitors and methods of their use
WO2008044243A3 (en) Novel process for the preparation of statins and their pharmaceutically acceptable salts thereof
WO2008030883A3 (en) Treatment of cancer
CL2007002578A1 (en) COMPOUNDS DERIVED FROM N- (1-FTALAZIN-1-IL-PIPERIDIN-4-IL) -AMIDAS; PHARMACEUTICAL COMPOSITION; AND USE FOR THE TREATMENT AND PREVENTION OF FERTILITY, OSTEOPOROSIS AND CANCER DISORDERS.
WO2007066336A3 (en) Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof
WO2007066337A3 (en) Jasmonate derivatives, pharmaceutical compositions and methods of use thereof
WO2008054808A3 (en) Elvucitabine pharmaceutical compositions
WO2009035634A3 (en) Cyanoaminoquinolones and tetrazoloaminoquinolones as gsk-3 inhibitors
WO2007146335A3 (en) Compounds and compositions for treatment of cancer

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07841631

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

NENP Non-entry into the national phase

Ref country code: RU

122 Ep: pct application non-entry in european phase

Ref document number: 07841631

Country of ref document: EP

Kind code of ref document: A2