WO2008025941A3 - Compounds for imaging and therapy - Google Patents

Compounds for imaging and therapy Download PDF

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Publication number
WO2008025941A3
WO2008025941A3 PCT/GB2007/002950 GB2007002950W WO2008025941A3 WO 2008025941 A3 WO2008025941 A3 WO 2008025941A3 GB 2007002950 W GB2007002950 W GB 2007002950W WO 2008025941 A3 WO2008025941 A3 WO 2008025941A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapy
complexes
imaging
compounds
metal
Prior art date
Application number
PCT/GB2007/002950
Other languages
French (fr)
Other versions
WO2008025941A2 (en
Inventor
Sofia Loana Pascu
Philip Alan Waghorn
Grant Charles Churchill
Robert Braidwood Sim
Original Assignee
Isis Innovation
Sofia Loana Pascu
Philip Alan Waghorn
Grant Charles Churchill
Robert Braidwood Sim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation, Sofia Loana Pascu, Philip Alan Waghorn, Grant Charles Churchill, Robert Braidwood Sim filed Critical Isis Innovation
Publication of WO2008025941A2 publication Critical patent/WO2008025941A2/en
Publication of WO2008025941A3 publication Critical patent/WO2008025941A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C337/00—Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
    • C07C337/08—Compounds containing any of the groups, e.g. thiosemicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. thiosemicarbazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/003—Compounds containing elements of Groups 2 or 12 of the Periodic Table without C-Metal linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention provides metal complexes of formula (I), wherein M is a transition metal or a p-block metal, and a, b, c, n, L, X, X', Y, Y', L1, L1', R1, R1', R2 and R2' are defined herein. Such complexes are useful in medical imaging and therapy, in particular, in the treatment of conditions characterised by undesirable cellular proliferation. The invention further provides processes for producing the complexes of the invention.
PCT/GB2007/002950 2006-09-01 2007-08-03 Compounds for imaging and therapy WO2008025941A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0617299A GB0617299D0 (en) 2006-09-01 2006-09-01 Compounds for imaging and therapy
GB0617299.3 2006-09-01

Publications (2)

Publication Number Publication Date
WO2008025941A2 WO2008025941A2 (en) 2008-03-06
WO2008025941A3 true WO2008025941A3 (en) 2008-04-17

Family

ID=37137230

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/002950 WO2008025941A2 (en) 2006-09-01 2007-08-03 Compounds for imaging and therapy

Country Status (2)

Country Link
GB (1) GB0617299D0 (en)
WO (1) WO2008025941A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103254266B (en) * 2013-05-19 2016-04-13 广西师范学院 Steroidal zinc metal complexes and preparation method thereof and the application in the anti-gastric cancer medicament of preparation
WO2023287857A1 (en) * 2021-07-14 2023-01-19 Washington University Systems and methods for low-count quantitative projection domain spect imaging

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3382266A (en) * 1964-10-28 1968-05-07 Pfizer & Co C Metal chelates of substituted bis-thio-semicarbazones of cyclic 1, 2-diketones
US20030187007A1 (en) * 2001-05-30 2003-10-02 Cao Sheldon Xiaodong Inhibitors of protein kinase for the treatment of disease
WO2005084168A2 (en) * 2003-09-08 2005-09-15 Proportional Technologies, Inc. MINIATURIZED 62Zn/62Cu GENERATOR FOR HIGH CONCENTRATION CLINICAL DELIVERY OF 62Cu KIT FORMULATION FOR THE FACILE PREPARATION OF RADIOLABELED Cu-BIS(THIOSEMICARBAZONE) COMPOUNDS

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3382266A (en) * 1964-10-28 1968-05-07 Pfizer & Co C Metal chelates of substituted bis-thio-semicarbazones of cyclic 1, 2-diketones
US20030187007A1 (en) * 2001-05-30 2003-10-02 Cao Sheldon Xiaodong Inhibitors of protein kinase for the treatment of disease
US20030208067A1 (en) * 2001-05-30 2003-11-06 Cao Sheldon Xiaodong Inhibitors of protein kinase for the treatment of disease
WO2005084168A2 (en) * 2003-09-08 2005-09-15 Proportional Technologies, Inc. MINIATURIZED 62Zn/62Cu GENERATOR FOR HIGH CONCENTRATION CLINICAL DELIVERY OF 62Cu KIT FORMULATION FOR THE FACILE PREPARATION OF RADIOLABELED Cu-BIS(THIOSEMICARBAZONE) COMPOUNDS

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002459285, Database accession no. 1967:463894 *
G. R. GUMMERUS, ET AL.: "Condensation products of some .alpha.-diketones especially 3-methyl-2-hydroxy-2-cyclopentenone with thiosemicarbazide", COMMENTALIONES PHYSICO MATHEMATICAE, vol. 32, no. 5, 1966, pages 1 - 43 *
G. R. GUMMERUS, ET AL.: "Über isomere Dithiosemicarbazone von Methylcyclopentenolonen", ACTA CHEMICA SCANDINAVICA, vol. 10, no. 3, 1956, MUNKSGAARD, COPENHAGEN, DK, pages 459 - 465, XP002459284 *
J.A. MCCLEVERTY, ET AL.: "Complexes of transition metals with Schiff bases and the factors influencing their redox properties. I. Nickel and copper complexes of some diketone bis-thiosemicarbazones", JOURNAL OF THE CHEMICAL SOCIETY, SECTION A: INORGANIC, PHYSICAL, THEORETICAL, no. 17, 1970, ROYAL SOCIETY OF CHEMISTRY LETCHWORTH, GB, pages 2829 - 2836, XP002459283 *

Also Published As

Publication number Publication date
WO2008025941A2 (en) 2008-03-06
GB0617299D0 (en) 2006-10-11

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