WO2008023268A3 - Leukemia mouse model conditionally expressing a bcr-abl oncogene - Google Patents
Leukemia mouse model conditionally expressing a bcr-abl oncogene Download PDFInfo
- Publication number
- WO2008023268A3 WO2008023268A3 PCT/IB2007/003288 IB2007003288W WO2008023268A3 WO 2008023268 A3 WO2008023268 A3 WO 2008023268A3 IB 2007003288 W IB2007003288 W IB 2007003288W WO 2008023268 A3 WO2008023268 A3 WO 2008023268A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bcr
- mouse model
- abl oncogene
- relates
- conditionally expressing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/20—Animal model comprising regulated expression system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/005—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB
- C12N2830/006—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB tet repressible
Abstract
The invention relates, to cancer development; more specifically, leukaemia. In particular, the invention relates to transgenic non-human animals comprising in their genome a human oncogene which can be regulated exogenously by an effector substance. The invention further relates to transgenic non-human animals comprising in their genome the BCR-ABLp 190 gene. In addition the invention relates to the use of the transgenic non-human mammals of the invention for the discovery and development of compounds for the prevention and/or treatment of cancer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06017630 | 2006-08-24 | ||
EP06017630.2 | 2006-08-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008023268A2 WO2008023268A2 (en) | 2008-02-28 |
WO2008023268A3 true WO2008023268A3 (en) | 2008-07-31 |
Family
ID=39107179
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2007/003288 WO2008023268A2 (en) | 2006-08-24 | 2007-08-23 | Leukemia mouse model conditionally expressing a bcr-abl oncogene |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008023268A2 (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991007489A1 (en) * | 1989-11-22 | 1991-05-30 | Childrens Hospital Of Los Angeles | Bcr/abl transgenic animals as models for philadelphia chromosome positive chronic myelogenous and acute lymphoblastic leukemia |
-
2007
- 2007-08-23 WO PCT/IB2007/003288 patent/WO2008023268A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991007489A1 (en) * | 1989-11-22 | 1991-05-30 | Childrens Hospital Of Los Angeles | Bcr/abl transgenic animals as models for philadelphia chromosome positive chronic myelogenous and acute lymphoblastic leukemia |
US5849996A (en) * | 1989-11-22 | 1998-12-15 | Childrens Hospital Of Los Angeles | BCR/ABL transgenic animals as models for Philadelphia chromosome positive chronic myelogenous and acute lymphoblastic leukemia |
Non-Patent Citations (6)
Title |
---|
BRAIN JULIA M ET AL: "The kinase inhibitor STI571 reverses the Bcr-Abl induced point mutation frequencies observed in pre-leukemic P190Bcr-Abl transgenic mice.", LEUKEMIA RESEARCH, vol. 26, no. 11, November 2002 (2002-11-01), pages 1011 - 1016, XP002480384, ISSN: 0145-2126 * |
CHOO Y ET AL: "IN VIVO REPRESSION BY A SITE-SPECIFIC DNA-BINDING PROTEIN DESIGNED AGAINST AN ONCOGENIC SEQUENCE", NATURE, NATURE PUBLISHING GROUP, LONDON, vol. 372, 15 December 1994 (1994-12-15), pages 642 - 645, XP000986225, ISSN: 0028-0836 * |
COBALEDA C ET AL: "In vivo inhibition by a site-specific catalytic RNA subunit of RNase P designed against the BCR-ABL oncogenic products: A novel approach for cancer treatment", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, vol. 95, no. 3, 1 February 2000 (2000-02-01), pages 731 - 737, XP002239466, ISSN: 0006-4971 * |
GARCÍA-HERNÁNDEZ B ET AL: "Retroviral vector design for gene therapy of cancer: specific inhibition and tagging of BCR-ABLp190 cells.", MOLECULAR MEDICINE (CAMBRIDGE, MASS.) JAN 1996, vol. 2, no. 1, January 1996 (1996-01-01), pages 125 - 133, XP001013586, ISSN: 1076-1551 * |
PEREZ-CARO M ET AL: "Sustained leukaemic phenotype after inactivation of BCR-ABLp190 in mice", ONCOGENE, vol. 26, no. 12, March 2007 (2007-03-01), pages 1702 - 1713, XP002480386, ISSN: 0950-9232 * |
VITALE-CROSS LYNN ET AL: "Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis", CANCER RESEARCH, vol. 64, no. 24, 15 December 2004 (2004-12-15), pages 8804 - 8807, XP002480385, ISSN: 0008-5472 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008023268A2 (en) | 2008-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AP2414A (en) | Fungicidal aqueous compositions for seed treatment. | |
HK1096555A1 (en) | Tissue products derived from animals lacking any expression of functional alpha 1,3 galactosyltransferase -13 | |
EP1910507A4 (en) | Wax emulsions for lingnocellulosic products, methods of their manufacture and products formed therefrom | |
WO2007141278A3 (en) | Human binding molecules having killing activity against enterococci and staphylococcus aureus and uses thereof | |
WO2010078324A3 (en) | Companion animal compositions including lipoic acid and methods of use thereof | |
AP2012006217A0 (en) | Soybean transgenic event mon 87708 and methods of use thereof. | |
WO2007117511A3 (en) | Feed formulations containing docosahexaenoic acid | |
EP2052043A4 (en) | Process for preparation of silver nanoparticles, and the compositions of silver ink containing the same | |
IL193746A (en) | Antimicrobial compositions and catheters containing the same and methods for production thereof | |
GB0718905D0 (en) | Methods, compositions and formulations for the treatment of thyroid eye disease | |
WO2009077500A3 (en) | Azolylmethyloxiranes, use thereof and agents containing the same | |
WO2009077471A3 (en) | Azolylmethyloxiranes, use thereof and agents containing the same | |
ZA200802072B (en) | Use of lactate esters for improving the action of agricultural pesticides | |
GB0718523D0 (en) | Agricultural treatment | |
WO2007080621A8 (en) | Luminescent transgenic non human animals, progeny, cell derivatives and uses thereof | |
EP2040718A4 (en) | Gallium nitrate formulations | |
IL187449A0 (en) | Variants at chr8q24.21 confer risk of cancer | |
GB0605715D0 (en) | Treatment of laminitis | |
GB2434732B (en) | Manufacture of animal feed supplements | |
EP1906727A4 (en) | Fish cancer model | |
WO2008011990A3 (en) | Synergistic insecticidal mixtures | |
GB0507490D0 (en) | Treatment of animal parasites | |
WO2008023268A3 (en) | Leukemia mouse model conditionally expressing a bcr-abl oncogene | |
WO2007002881A3 (en) | Compositions and methods of use of derivatized flavanols | |
GB0606868D0 (en) | Animal deterrent |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07825546 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
NENP | Non-entry into the national phase |
Ref country code: RU |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 07825546 Country of ref document: EP Kind code of ref document: A2 |