WO2008015696A3 - Process for preparing ciclesonide - Google Patents
Process for preparing ciclesonide Download PDFInfo
- Publication number
- WO2008015696A3 WO2008015696A3 PCT/IN2007/000206 IN2007000206W WO2008015696A3 WO 2008015696 A3 WO2008015696 A3 WO 2008015696A3 IN 2007000206 W IN2007000206 W IN 2007000206W WO 2008015696 A3 WO2008015696 A3 WO 2008015696A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ciclesonide
- preparing
- preparing ciclesonide
- enriching
- enantiomeric
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A process for enantiomeric enriching the (R)-Ciclesonide is enclosed. The process comprises providing mixture of (R)-Ciclesonide: (S)-Ciclesonide to chromatography using a chiral stationary phase.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN785MU2006 | 2006-05-23 | ||
IN785/MUM/2006 | 2006-05-23 | ||
IN1093MU2006 | 2006-07-10 | ||
IN1093/MUM/2006 | 2006-07-10 | ||
IN1196/MUM/2006 | 2006-07-28 | ||
IN1196MU2006 | 2006-07-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008015696A2 WO2008015696A2 (en) | 2008-02-07 |
WO2008015696A3 true WO2008015696A3 (en) | 2008-05-29 |
Family
ID=38997576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2007/000206 WO2008015696A2 (en) | 2006-05-23 | 2007-05-22 | Process for preparing ciclesonide |
Country Status (1)
Country | Link |
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WO (1) | WO2008015696A2 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2007298770B2 (en) * | 2006-09-19 | 2013-01-31 | Cipla Limited | Processes for the preparation of ciclesonide and its crystal form |
CA2714653A1 (en) * | 2008-03-13 | 2009-09-17 | Farmabios S.P.A. | Process for the preparation of pregnane derivatives |
WO2010054158A2 (en) * | 2008-11-07 | 2010-05-14 | Auspex Pharmaceuticals, Inc. | Steroid modulators of glucocorticoid receptor |
US9109005B2 (en) | 2012-02-23 | 2015-08-18 | Boehringer Ingelheim International Gmbh | Method for manufacturing of ciclesonide |
CN106883283B (en) * | 2015-12-15 | 2021-02-02 | 天津金耀集团有限公司 | Ciclesonide monohydrate, crystal form and preparation method thereof |
PL3464318T3 (en) | 2016-06-02 | 2021-11-08 | Abbvie Inc. | Glucocorticoid receptor agonist and immunoconjugates thereof |
CN107778343A (en) * | 2016-08-30 | 2018-03-09 | 天津太平洋制药有限公司 | A kind of preparation method of ciclesonide |
US10772970B2 (en) | 2017-12-01 | 2020-09-15 | Abbvie Inc. | Glucocorticoid receptor agonist and immunoconjugates thereof |
CN109293730A (en) * | 2018-10-23 | 2019-02-01 | 山东泰华生物科技股份有限公司 | A kind of preparation method of ciclesonide |
CN113117653B (en) * | 2021-04-19 | 2022-03-25 | 中国科学院兰州化学物理研究所 | Preparation and application of carboxylic acid modified cyclodextrin chiral chromatographic stationary phase material |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4129535A1 (en) * | 1990-09-07 | 1992-03-12 | Elmu Sa | Novel PREGNA-1,4-DIEN-3,20-DION-16-17-ACETAL-21-ESTERS, METHOD FOR THE PREPARATION, COMPOSITION, AND METHODS OF TREATMENT |
WO1994022899A1 (en) * | 1993-04-02 | 1994-10-13 | Byk Gulden Lomberg Chemische Fabrik Gmbh | New prednisolone derivates |
WO1995024416A1 (en) * | 1994-03-09 | 1995-09-14 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel silyl compounds and their use |
WO1998009982A1 (en) * | 1996-09-03 | 1998-03-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Process for r-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11.beta.,16.alpha.,17.alpha.-triol-3,20-dione derivatives |
WO2002038584A1 (en) * | 2000-11-10 | 2002-05-16 | Altana Pharma Ag | Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-dihydroxy-pregna-1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation |
DE10055820C1 (en) * | 2000-11-10 | 2002-07-25 | Byk Gulden Lomberg Chem Fab | Preparation of 16,17-cyclohexylmethylene-dioxy-pregnadiene derivative, useful as glucocorticoid, by reacting 16,17-ketal with cyclohexylaldehyde to give high epimeric purity |
WO2004085460A1 (en) * | 2003-03-27 | 2004-10-07 | Altana Pharma Ag | Process for preparing crystalline ciclesonide with defined particle size |
CN1699395A (en) * | 2005-06-21 | 2005-11-23 | 浙江仙琚制药股份有限公司 | Process for preparing perdnisolone derivatives by one-pot method |
WO2007056181A2 (en) * | 2005-11-02 | 2007-05-18 | Sicor, Inc. | Process for the preparation of ciclesonide |
-
2007
- 2007-05-22 WO PCT/IN2007/000206 patent/WO2008015696A2/en active Application Filing
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4129535A1 (en) * | 1990-09-07 | 1992-03-12 | Elmu Sa | Novel PREGNA-1,4-DIEN-3,20-DION-16-17-ACETAL-21-ESTERS, METHOD FOR THE PREPARATION, COMPOSITION, AND METHODS OF TREATMENT |
WO1994022899A1 (en) * | 1993-04-02 | 1994-10-13 | Byk Gulden Lomberg Chemische Fabrik Gmbh | New prednisolone derivates |
WO1995024416A1 (en) * | 1994-03-09 | 1995-09-14 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel silyl compounds and their use |
WO1998009982A1 (en) * | 1996-09-03 | 1998-03-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Process for r-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11.beta.,16.alpha.,17.alpha.-triol-3,20-dione derivatives |
WO2002038584A1 (en) * | 2000-11-10 | 2002-05-16 | Altana Pharma Ag | Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-dihydroxy-pregna-1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation |
DE10055820C1 (en) * | 2000-11-10 | 2002-07-25 | Byk Gulden Lomberg Chem Fab | Preparation of 16,17-cyclohexylmethylene-dioxy-pregnadiene derivative, useful as glucocorticoid, by reacting 16,17-ketal with cyclohexylaldehyde to give high epimeric purity |
WO2004085460A1 (en) * | 2003-03-27 | 2004-10-07 | Altana Pharma Ag | Process for preparing crystalline ciclesonide with defined particle size |
CN1699395A (en) * | 2005-06-21 | 2005-11-23 | 浙江仙琚制药股份有限公司 | Process for preparing perdnisolone derivatives by one-pot method |
US20070117974A1 (en) * | 2005-06-21 | 2007-05-24 | Zhejiang Xianju Pharmaceutical Co., Ltd. | One-pot processes for preparing prednisolone derivatives |
WO2007056181A2 (en) * | 2005-11-02 | 2007-05-18 | Sicor, Inc. | Process for the preparation of ciclesonide |
Non-Patent Citations (1)
Title |
---|
GADZALA-KOPCIUCH, R. ET AL: "Silicon dioxide surfaces with aryl interaction sites for chromatographic applications", MATERIALS CHEMISTRY AND PHYSICS , VOLUME DATE 2005, 89(2-3), 228-237 CODEN: MCHPDR; ISSN: 0254-0584, 2004, XP002474702 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008015696A2 (en) | 2008-02-07 |
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