WO2008015383A8 - Bmp-9 and bmp-10 and their use in breast and prostate cancer therapies - Google Patents

Bmp-9 and bmp-10 and their use in breast and prostate cancer therapies Download PDF

Info

Publication number
WO2008015383A8
WO2008015383A8 PCT/GB2007/002755 GB2007002755W WO2008015383A8 WO 2008015383 A8 WO2008015383 A8 WO 2008015383A8 GB 2007002755 W GB2007002755 W GB 2007002755W WO 2008015383 A8 WO2008015383 A8 WO 2008015383A8
Authority
WO
WIPO (PCT)
Prior art keywords
bmp
breast
prostate cancer
cancer therapies
therapies
Prior art date
Application number
PCT/GB2007/002755
Other languages
French (fr)
Other versions
WO2008015383A2 (en
WO2008015383A3 (en
Inventor
Wen Guo Jiang
Original Assignee
Univ Cardiff
Wen Guo Jiang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cardiff, Wen Guo Jiang filed Critical Univ Cardiff
Publication of WO2008015383A2 publication Critical patent/WO2008015383A2/en
Publication of WO2008015383A3 publication Critical patent/WO2008015383A3/en
Publication of WO2008015383A8 publication Critical patent/WO2008015383A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention relates to the role of BMP-9 and/or BMP-10 in the treatment of breast or prostate cancer.
PCT/GB2007/002755 2006-07-29 2007-07-20 Bmp-9 and bmp-10 and their use in breast and prostate cancer therapies WO2008015383A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0615129.4 2006-07-29
GBGB0615129.4A GB0615129D0 (en) 2006-07-29 2006-07-29 Anti-cancer activity of BMP-9 and BMP-10 and their use in cancer therapies

Publications (3)

Publication Number Publication Date
WO2008015383A2 WO2008015383A2 (en) 2008-02-07
WO2008015383A3 WO2008015383A3 (en) 2008-08-14
WO2008015383A8 true WO2008015383A8 (en) 2009-07-16

Family

ID=37006438

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/002755 WO2008015383A2 (en) 2006-07-29 2007-07-20 Bmp-9 and bmp-10 and their use in breast and prostate cancer therapies

Country Status (2)

Country Link
GB (1) GB0615129D0 (en)
WO (1) WO2008015383A2 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2332977B1 (en) 2004-07-23 2015-11-25 Acceleron Pharma Inc. ActRII receptor polypeptides
US8128933B2 (en) 2005-11-23 2012-03-06 Acceleron Pharma, Inc. Method of promoting bone growth by an anti-activin B antibody
KR20190006086A (en) 2005-11-23 2019-01-16 악셀레론 파마 인코포레이티드 Activin-actrπa antagonists and uses for promoting bone growth
US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
RU2473362C2 (en) 2007-02-01 2013-01-27 Акселерон Фарма Инк. ACTIVIN-ActRIIa-Fc ANTAGONISTS AND USE THEREOF FOR TREATING OR PREVENTING BREAST CANCER
TWI548647B (en) 2007-02-02 2016-09-11 艾瑟勒朗法瑪公司 Variants derived from actriib and uses therefor
EA025371B1 (en) 2007-02-09 2016-12-30 Акселерон Фарма Инк. ACTIVIN-ActRIIa ANTAGONISTS AND USE FOR PROMOTING BONE GROWTH IN CANCER PATIENTS
EP3243524A1 (en) 2007-09-18 2017-11-15 Acceleron Pharma Inc. Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion
WO2009084738A1 (en) * 2007-12-28 2009-07-09 Kyowa Hakko Kirin Co., Ltd. Method and pharmaceutical composition for treatment of cancer using bmp9 protein
WO2009084739A1 (en) * 2007-12-28 2009-07-09 Kyowa Hakko Kirin Co., Ltd. Method and pharmaceutical composition for treatment of cancer using bmp10 protein,
LT3494986T (en) 2008-08-14 2020-07-10 Acceleron Pharma Inc. Gdf traps
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
WO2010083034A1 (en) 2009-01-13 2010-07-22 Acceleron Pharma Inc. Methods for increasing adiponectin
US8178488B2 (en) 2009-06-08 2012-05-15 Acceleron Pharma, Inc. Methods for increasing thermogenic adipocytes
KR20190090049A (en) 2009-06-12 2019-07-31 악셀레론 파마 인코포레이티드 TRUNCATED ActRIIB-FC FUSION PROTEINS
ES2658292T3 (en) 2009-11-17 2018-03-09 Acceleron Pharma, Inc. ActRIIB proteins and variants and uses thereof with respect to the induction of utrophin for the treatment of muscular dystrophy
US20120121576A1 (en) 2010-11-08 2012-05-17 Jasbir Seehra Actriia binding agents and uses thereof
US9809636B2 (en) 2012-04-06 2017-11-07 Acceleron Pharma Inc. Methods for increasing red blood cell levels comprising administering BMP9
CA2890217C (en) 2012-11-02 2021-07-20 Yifu FANG Activin-actrii antagonists and uses for treating bone and other disorders
AU2015274277B2 (en) 2014-06-13 2021-03-18 Acceleron Pharma, Inc. Methods and compositions for treating ulcers
MA41052A (en) 2014-10-09 2017-08-15 Celgene Corp TREATMENT OF CARDIOVASCULAR DISEASE USING ACTRII LIGAND TRAPS
DK3227675T3 (en) 2014-12-03 2023-05-30 Celgene Corp ACTIVIN-ACTRII ANTAGONISTS AND USES FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROME
CA2995310A1 (en) 2015-08-25 2017-03-02 Histide Ag Compounds for inducing tissue formation and uses thereof
CN109715191A (en) * 2015-09-17 2019-05-03 伊斯迪德股份公司 Pharmaceutical associations for the conversion of neoplastic cells into non-neoplastic cells and uses thereof
CN109715190A (en) * 2015-09-17 2019-05-03 伊斯迪德股份公司 Pharmaceutical associations of growth factor receptor agonists and adhesion protein inhibitors for converting neoplastic cells to non-neoplastic cells and uses thereof
WO2023069447A1 (en) * 2021-10-18 2023-04-27 The Uab Research Foundation Bmp9 or an agonist thereof and its uses related to reducing metastasis of cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2226467T5 (en) * 1998-11-13 2009-08-27 Stryker Corporation RELIEF OF THE SYMPTOMS OF CANCER DE PROSTATA.
US20060039949A1 (en) * 2004-08-20 2006-02-23 Nycz Jeffrey H Acetabular cup with controlled release of an osteoinductive formulation
EP1802326A2 (en) * 2004-09-09 2007-07-04 Stryker Corporation Methods for treating bone tumors using bone morphogenic proteins

Also Published As

Publication number Publication date
GB0615129D0 (en) 2006-09-06
WO2008015383A2 (en) 2008-02-07
WO2008015383A3 (en) 2008-08-14

Similar Documents

Publication Publication Date Title
WO2008015383A3 (en) Bmp-9 and bmp-10 and their use in breast and prostate cancer therapies
WO2008076278A3 (en) Methods of cancer treatment with igf1r inhibitors
IL184617A0 (en) Dr5 antibodies and uses thereof
WO2007127010A3 (en) Diarylthiohydantoin compounds
IL195731A0 (en) Pyrimidine derivatives useful in the treatment of cancer
MX2019015200A (en) Diarylhydantoin compounds.
WO2006113483A3 (en) Methods and compositions for treating or preventing cancer
HK1170485A1 (en) 1,2,4-thiazolidin-3-one derivatives and their use in the treatment of cancer 124--3-
EP2173740A4 (en) Heme-oxygenase inhibitors and use of the same in the treatment of cancer and diseases of the central nervous system
WO2009053041A3 (en) Identification of tumor-associated markers for diagnosis and therapy
WO2008089397A3 (en) Adrb2 cancer markers
WO2008150530A3 (en) Cripto binding molecules
HUE037109T2 (en) Endoxifen for use in the treatment of cancer
HK1215683A1 (en) Antifolate agent combinations in the treatment of cancer
WO2008060945A3 (en) Diagnosis and treatment of breast cancer
WO2007100920A3 (en) Diagnosis and treatment of prostate cancer
MX2012001513A (en) Use of melanocortins to treat dyslipidemia.
AU2006251169A8 (en) Tetrahydropyridothiophenes for use in the treatment of cancer
AU2006251167A8 (en) Tetrahydropyridothiophenes for use in the treatment of cancer
ZA200709542B (en) Combination therapy in the treatment of cancer
WO2009074253A3 (en) Clofarabine dietherphospholipid derivatives
WO2009046123A3 (en) Nlrr-1 antagonists and uses thereof
WO2008061048A3 (en) Methods and compositions for diagnosing and treating prostate cancer
WO2008009895A3 (en) Matriptase-2
WO2008092103A3 (en) Combination cancer treatments comprising elsamitrucin and other agents

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07766318

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase in:

Ref country code: DE

NENP Non-entry into the national phase in:

Ref country code: RU

122 Ep: pct application non-entry in european phase

Ref document number: 07766318

Country of ref document: EP

Kind code of ref document: A2