WO2007147122A3 - Monoclonal antibodies that selectively recognize methamphetamine and methamphetamine like compounds - Google Patents

Monoclonal antibodies that selectively recognize methamphetamine and methamphetamine like compounds Download PDF

Info

Publication number
WO2007147122A3
WO2007147122A3 PCT/US2007/071354 US2007071354W WO2007147122A3 WO 2007147122 A3 WO2007147122 A3 WO 2007147122A3 US 2007071354 W US2007071354 W US 2007071354W WO 2007147122 A3 WO2007147122 A3 WO 2007147122A3
Authority
WO
WIPO (PCT)
Prior art keywords
methamphetamine
monoclonal antibodies
compounds
selectively recognize
recognize
Prior art date
Application number
PCT/US2007/071354
Other languages
French (fr)
Other versions
WO2007147122A2 (en
Inventor
Michael S Owens
Melinda Gunnell
Ivy F Carroll
Yingni Chi
Ralph Henry
Eric Peterson
Original Assignee
Univ Arkansas
Michael S Owens
Melinda Gunnell
Ivy F Carroll
Yingni Chi
Ralph Henry
Eric Peterson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Arkansas, Michael S Owens, Melinda Gunnell, Ivy F Carroll, Yingni Chi, Ralph Henry, Eric Peterson filed Critical Univ Arkansas
Priority to ES07798645T priority Critical patent/ES2415655T3/en
Priority to EP07798645A priority patent/EP2032602B1/en
Publication of WO2007147122A2 publication Critical patent/WO2007147122A2/en
Publication of WO2007147122A3 publication Critical patent/WO2007147122A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention generally relates to monoclonal antibodies that recognize at least one compound from the group consisting of (+) methamphetamine, (+) amphetamine, and (+) 3,4-methylenedioxymethamphetamine ((+) MDMA). Generally speaking, the monoclonal antibodies do not recognize (-) methamphetamine, (-) amphetamine, or (-) MDMA.
PCT/US2007/071354 2006-06-15 2007-06-15 Monoclonal antibodies that selectively recognize methamphetamine and methamphetamine like compounds WO2007147122A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES07798645T ES2415655T3 (en) 2006-06-15 2007-06-15 Monoclonal antibodies that selectively recognize methamphetamine and methamphetamine-like compounds
EP07798645A EP2032602B1 (en) 2006-06-15 2007-06-15 Monoclonal antibodies that selectively recognize methamphetamine and methamphetamine like compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US81391706P 2006-06-15 2006-06-15
US60/813,917 2006-06-15
US91312407P 2007-04-20 2007-04-20
US60/913,124 2007-04-20

Publications (2)

Publication Number Publication Date
WO2007147122A2 WO2007147122A2 (en) 2007-12-21
WO2007147122A3 true WO2007147122A3 (en) 2008-05-02

Family

ID=38832909

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/071354 WO2007147122A2 (en) 2006-06-15 2007-06-15 Monoclonal antibodies that selectively recognize methamphetamine and methamphetamine like compounds

Country Status (4)

Country Link
US (1) US7858756B2 (en)
EP (1) EP2032602B1 (en)
ES (1) ES2415655T3 (en)
WO (1) WO2007147122A2 (en)

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US7632929B2 (en) 2000-04-20 2009-12-15 The Board Of Trustees Of The University Of Arkansas Methamphetamine-like hapten compounds, linkers, carriers and compositions and uses thereof
EP4001409A1 (en) * 2006-03-31 2022-05-25 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
SI2047863T1 (en) * 2006-06-08 2013-11-29 Chugai Seiyaku Kabushiki Kaisha Preventive or remedy for inflammatory disease
ES2415655T3 (en) 2006-06-15 2013-07-26 The Board Of Trustees Of The University Of Arkansas Monoclonal antibodies that selectively recognize methamphetamine and methamphetamine-like compounds
EP2140263B1 (en) 2007-04-20 2017-01-04 The Board of Trustees of The University of Arkansas Hapten compounds and compositions and uses thereof
ES2595638T3 (en) 2007-09-26 2017-01-02 Chugai Seiyaku Kabushiki Kaisha Method to modify the isoelectric point of an antibody by replacing amino acids in a CDR
PE20090711A1 (en) * 2007-09-26 2009-07-15 Chugai Pharmaceutical Co Ltd CONSTANT REGION OF MUTANT ANTIBODY
MX2010006097A (en) * 2007-12-05 2010-08-04 Chugai Pharmaceutical Co Ltd Therapeutic agent for pruritus.
JP5682995B2 (en) * 2007-12-05 2015-03-11 中外製薬株式会社 Anti-NR10 antibody and use thereof
KR102084925B1 (en) 2008-04-11 2020-03-05 추가이 세이야쿠 가부시키가이샤 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
KR20160062207A (en) * 2008-12-05 2016-06-01 추가이 세이야쿠 가부시키가이샤 Anti-NR10 antibody and use thereof
JP5787446B2 (en) 2009-03-19 2015-09-30 中外製薬株式会社 Antibody constant region variants
JP5717624B2 (en) 2009-03-19 2015-05-13 中外製薬株式会社 Antibody constant region variants
CN108715614A (en) 2010-11-30 2018-10-30 中外制药株式会社 The antigen binding molecules combined are repeated with polymolecular antigen
GB201202223D0 (en) * 2012-02-09 2012-03-28 Randox Lab Ltd Immunoassay for pyrrolidinophenones
US10550201B2 (en) 2013-03-13 2020-02-04 Bioventures, Llc Antibody-nanoparticle conjugates for the treatment of drug abuse
US9023353B2 (en) 2013-03-13 2015-05-05 The Board Of Trustees Of The University Of Arkansas Anti-(+)—methamphetamine monoclonal antibodies
WO2014160075A1 (en) * 2013-03-13 2014-10-02 The Board Of Trustees Of The University Of Arkansas Antibody-nanoparticle conjugates for the treatment of drug abuse
GB2530783A (en) 2014-10-02 2016-04-06 Randox Lab Ltd Improved immunoassay for pyrrolidinophenones
RU2749512C2 (en) 2015-04-14 2021-06-11 Чугаи Сейяку Кабусики Кайся Pharmaceutical composition for prevention and/or treatment of atopic dermatitis, including il-31 antagonist as the active ingredient
CN114728064A (en) 2019-11-20 2022-07-08 中外制药株式会社 Antibody-containing preparation
CN117088982B (en) * 2022-05-11 2024-06-21 东莞市朋志生物科技有限公司 Anti-methamphetamine antibodies, reagents and kits for detecting methamphetamine

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US20030171435A1 (en) * 2002-01-23 2003-09-11 Drug Abuse Sciences, Inc. New amphetamine derivatives, antibodies against them and pharmaceutical compositions containing them
US7037669B2 (en) * 2004-03-22 2006-05-02 Dade Behring Inc. Assays for amphetamine and methamphetamine using stereospecific reagents

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Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030119083A1 (en) * 2000-04-20 2003-06-26 Owens Samuel M. Monoclonal antibody antagonists for treating medical problems associated with d-amphetamine-like drugs
US20030171435A1 (en) * 2002-01-23 2003-09-11 Drug Abuse Sciences, Inc. New amphetamine derivatives, antibodies against them and pharmaceutical compositions containing them
US7037669B2 (en) * 2004-03-22 2006-05-02 Dade Behring Inc. Assays for amphetamine and methamphetamine using stereospecific reagents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
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LAURENZANA ET AL.: "Use of anti-(+)-methamphetamine monoclonal antibody to significantly after (+)-methamphetamine and (+)-amphetamine disposition in rats", DRUG METABOLISM AND DISPOSITION, vol. 31, 2003, pages 1320 - 1326, XP008101343 *
See also references of EP2032602A4 *

Also Published As

Publication number Publication date
EP2032602A4 (en) 2010-07-14
US7858756B2 (en) 2010-12-28
US20080125579A1 (en) 2008-05-29
EP2032602A2 (en) 2009-03-11
ES2415655T3 (en) 2013-07-26
WO2007147122A2 (en) 2007-12-21
EP2032602B1 (en) 2013-03-27

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