WO2007146039A3 - Formes cristallines du n-[5-[[[5-(1,1-diméthyléthyl)-2-oxazolyl]méthyl]thio]-2-thiazolyl]-4-pipéridinecarboxamide - Google Patents

Formes cristallines du n-[5-[[[5-(1,1-diméthyléthyl)-2-oxazolyl]méthyl]thio]-2-thiazolyl]-4-pipéridinecarboxamide Download PDF

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Publication number
WO2007146039A3
WO2007146039A3 PCT/US2007/013384 US2007013384W WO2007146039A3 WO 2007146039 A3 WO2007146039 A3 WO 2007146039A3 US 2007013384 W US2007013384 W US 2007013384W WO 2007146039 A3 WO2007146039 A3 WO 2007146039A3
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WO
WIPO (PCT)
Prior art keywords
dimethylethyl
oxazolyl
thiazolyl
thio
crystalline forms
Prior art date
Application number
PCT/US2007/013384
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English (en)
Other versions
WO2007146039A2 (fr
Inventor
Jack Z Gougoutas
Mary F Malley
John D Dimarco
Soojin Kim
Hai-Yun Xiao
Raj Narain Misra
Original Assignee
Bristol Myers Squibb Co
Jack Z Gougoutas
Mary F Malley
John D Dimarco
Soojin Kim
Hai-Yun Xiao
Raj Narain Misra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co, Jack Z Gougoutas, Mary F Malley, John D Dimarco, Soojin Kim, Hai-Yun Xiao, Raj Narain Misra filed Critical Bristol Myers Squibb Co
Priority to EP07795829A priority Critical patent/EP2044066A2/fr
Priority to JP2009514368A priority patent/JP2009539846A/ja
Publication of WO2007146039A2 publication Critical patent/WO2007146039A2/fr
Publication of WO2007146039A3 publication Critical patent/WO2007146039A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
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Abstract

L'invention concerne des formes cristallines du N-[5-[[[5-(1,1-diméthyléthyl)-2-oxazolyl]méthyl]thio]-2-thiazolyl]-4-pipéridinecarboxamide. L'invention concerne également une composition pharmaceutique comprenant une ou plusieurs formes cristallines du N-[5-[[[5-(1,1-diméthyléthyl)-2-oxazolyl]méthyl]thio]-2-thiazolyl]-4-pipéridinecarboxamide, ainsi qu'un procédé d'utilisation desdites formes cristallines pour traiter les cancers et autres maladies prolifératives.
PCT/US2007/013384 2006-06-06 2007-06-06 Formes cristallines du n-[5-[[[5-(1,1-diméthyléthyl)-2-oxazolyl]méthyl]thio]-2-thiazolyl]-4-pipéridinecarboxamide WO2007146039A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07795829A EP2044066A2 (fr) 2006-06-06 2007-06-06 Formes cristallines du n-[5-[[[5-(1,1-diméthyléthyl)-2-oxazolyl]méthyl] thio]-2-thiazolyl]-4-pipéridinecarboxamide
JP2009514368A JP2009539846A (ja) 2006-06-06 2007-06-06 Ｎ−［５−［［［５−（１，１−ジメチルエチル）−２−オキサゾリル］メチル］チオ］−２−チアゾリル］−４−ピペリジンカルボキサミドの結晶形

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81148206P 2006-06-06 2006-06-06
US60/811,482 2006-06-06

Publications (2)

Publication Number Publication Date
WO2007146039A2 WO2007146039A2 (fr) 2007-12-21
WO2007146039A3 true WO2007146039A3 (fr) 2008-07-17

Family

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PCT/US2007/013384 WO2007146039A2 (fr) 2006-06-06 2007-06-06 Formes cristallines du n-[5-[[[5-(1,1-diméthyléthyl)-2-oxazolyl]méthyl]thio]-2-thiazolyl]-4-pipéridinecarboxamide

Country Status (3)

Country Link
EP (1) EP2044066A2 (fr)
JP (1) JP2009539846A (fr)
WO (1) WO2007146039A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008036954A1 (fr) * 2006-09-21 2008-03-27 Sunesis Pharmaceuticals, Inc. Procédés et compositions pour le traitement du cancer
KR101643280B1 (ko) * 2014-09-02 2016-07-28 한국원자력의학원 항암 효과, 방사선 병용치료 효과 및 당뇨병 치료 효과를 갖는 피페리딘카복사마이드 유도체 및 이의 의학적 용도

Citations (5)

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Publication number Priority date Publication date Assignee Title
WO2001080813A2 (fr) * 2000-04-27 2001-11-01 Bristol-Myers Squibb Company Methodes de prevention et de traitement de l'alopecie provoquee par la chimiotherapie ou la radiotherapie
WO2002010162A1 (fr) * 2000-07-26 2002-02-07 Bristol-Myers Squibb Company Inhibiteurs n-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl] carboxamide de la kinase dependantes des cyclines
US6515004B1 (en) * 1999-12-15 2003-02-04 Bristol-Myers Squibb Company N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
US6521759B2 (en) * 1999-12-15 2003-02-18 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
US6639074B2 (en) * 1999-12-15 2003-10-28 Bristol Myers Squibb Company Process for preparing azacycloalkanoylaminothiazoles

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CN1121403C (zh) * 1997-02-27 2003-09-17 辉瑞大药厂 喹喔啉二酮
GB9711127D0 (en) * 1997-05-29 1997-07-23 Leo Pharm Prod Ltd Novel cyanoguanidines
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
WO2001010824A1 (fr) * 1999-08-10 2001-02-15 Lonza Ag Dicyanatochalcones et leur procede de production

Patent Citations (5)

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US6515004B1 (en) * 1999-12-15 2003-02-04 Bristol-Myers Squibb Company N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
US6521759B2 (en) * 1999-12-15 2003-02-18 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
US6639074B2 (en) * 1999-12-15 2003-10-28 Bristol Myers Squibb Company Process for preparing azacycloalkanoylaminothiazoles
WO2001080813A2 (fr) * 2000-04-27 2001-11-01 Bristol-Myers Squibb Company Methodes de prevention et de traitement de l'alopecie provoquee par la chimiotherapie ou la radiotherapie
WO2002010162A1 (fr) * 2000-07-26 2002-02-07 Bristol-Myers Squibb Company Inhibiteurs n-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl] carboxamide de la kinase dependantes des cyclines

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GOULD P L: "SALT SELECTION FOR BASIC DRUGS", INTERNATIONAL JOURNAL OF PHARMACEUTICS, AMSTERDAM, NL, vol. 33, no. 1/3, 1986, pages 201 - 217, XP002074725, ISSN: 0378-5173 *
HALEBLIAN J ET AL: "PHARMACEUTICAL APPLICATIONS OF POLYMORPHISM", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 58, no. 8, August 1969 (1969-08-01), pages 911 - 929, XP002020518, ISSN: 0022-3549 *
MISRA RAJ N ET AL: "N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thi azolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 47, no. 7, 25 March 2004 (2004-03-25), pages 1719 - 1728, XP002302339, ISSN: 0022-2623 *
MORISSETTE SHERRY L ET AL: "HIGH-THROUGHPUT CRYSTALLIZATION: POLYMORPHS, SALTS, CO-CRYSTALS AND SOLCATES OF PHARMACEUTICAL SOLIDS", ADVANCED DRUG DELIVERY REVIEWS, AMSTERDAM, NL, vol. 56, no. 3, 2004, pages 275 - 300, XP009072233, ISSN: 0169-409X *
TONG W-Q ET AL: "IN SITU SALT SCREENING-A USEFUL TECHNIQUE FOR DISCOVERY SUPPORT AND PREFORMULATION STUDIES", PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, NEW YORK, NY, US, vol. 3, no. 2, May 1998 (1998-05-01), pages 215 - 223, XP001203865, ISSN: 1083-7450 *
YU L ET AL: "PHYSICAL CHARACTERIZATION OF POLYMORPHIC DRUGS: AN INTEGRATED CHARACTERIZATION STRATEGY", PHARMACEUTICAL SCIENCE AND TECHNOLOGY TODAY, ELSEVIER TRENDS JOURNALS, CAMBRIDGE,, GB, vol. 1, no. 3, June 1998 (1998-06-01), pages 118 - 127, XP000949322, ISSN: 1461-5347 *

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WO2007146039A2 (fr) 2007-12-21
EP2044066A2 (fr) 2009-04-08
JP2009539846A (ja) 2009-11-19

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