WO2007118338A1 - Milk serum supplemented aqueous solutions - Google Patents

Milk serum supplemented aqueous solutions Download PDF

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Publication number
WO2007118338A1
WO2007118338A1 PCT/CH2006/000211 CH2006000211W WO2007118338A1 WO 2007118338 A1 WO2007118338 A1 WO 2007118338A1 CH 2006000211 W CH2006000211 W CH 2006000211W WO 2007118338 A1 WO2007118338 A1 WO 2007118338A1
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WO
WIPO (PCT)
Prior art keywords
milk serum
composition
water
dried
solids
Prior art date
Application number
PCT/CH2006/000211
Other languages
French (fr)
Inventor
Georg Schäfer
Original Assignee
Emmi Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emmi Ag filed Critical Emmi Ag
Priority to PCT/CH2006/000211 priority Critical patent/WO2007118338A1/en
Publication of WO2007118338A1 publication Critical patent/WO2007118338A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/14—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
    • A23C9/142—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration
    • A23C9/1425—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration by ultrafiltration, microfiltration or diafiltration of whey, e.g. treatment of the UF permeate
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/14—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
    • A23C9/142—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration
    • A23C9/1422—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration by ultrafiltration, microfiltration or diafiltration of milk, e.g. for separating protein and lactose; Treatment of the UF permeate
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/1522—Inorganic additives, e.g. minerals, trace elements; Chlorination or fluoridation of milk; Organic salts or complexes of metals other than natrium or kalium; Calcium enrichment of milk
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/158—Milk preparations; Milk powder or milk powder preparations containing additives containing vitamins or antibiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention concerns milk serum (lactoserum) comprising aqueous solutions supplemented with poorly water soluble or water insoluble and/or poorly water wetable or water non-wetable and possibly also oxidation sensitive ingredients such as hydrophobic vitamins and coenzymes, in particular ubiquinones, especially coenzyme QlO.
  • Vitamins comprising preparations are e.g. vitamins supplemented energy drinks .
  • Such drinks comprise e.g. water soluble vitamins and water-soluble derivatives of fat-soluble vitamins and minerals.
  • a disadvantage of such drinks is that - due to the instability of many vitamins in contact with humidity and/or oxygen and/or light, necessitating to add a surplus of them to ensure the declared amount at the end of the marked storage time.
  • alternative or usual preparations are in the form of water disintegrating tablets, in particular effervescent tablets, or, especially for water insoluble substances, in the form of capsules .
  • Coenzyme QlO is an essential component of cellular energy metabolism, in particular respiration, and thus is a very desirable ingredient in preparations intended for active people or in preparations intended as nutritional supplements to improve the health status and the vitality of people in need thereof.
  • the amount of substance actually consumed is unpredictable and may to a high extent depend on the time elapsed between the disintegration of the tablet and the actual time of consumption, the more so since many people prefer to take few sips several times during a certain time than a whole glass at once.
  • reference to substances that in water are poorly soluble also includes substances that are insoluble in water (water insoluble substances) , substances that are poorly wetted by water (poorly water wetable substances) and substances that are not wetted by water (not water wetable substances) .
  • Poorly water soluble means that the respective substance has a solubility in water at 5°C of less than 10 mg/100 ml, in general less than 7 mg/100 ml.
  • the invention is much advantageous in connection with substances having a solubility of less than 5 mg/100 ml or even an as low solubility as less than 3 or even 2 mg/100 ml. It has now surprisingly be found that milk serum (lactoserum) is a very efficient medium to improve the solubility or dispersibility and the wetability of lipophilic/hydrophobic substances .
  • milk serum or lactoserum respectively, is not used as synonym to whey but means the liquid resulting after removal of the proteins and the fats from milk or whey.
  • Milk serum suitable for use in the present invention may be non-acidic, acidic (e.g. obtained from sour-whey) or acidified. While whey in general still comprises about 20% of the originally present milk proteins, the milk serum (lactoserum) in general has a milk-fat content of less than 100 mg/100 g, usually less than about 50 mg/100 g, and a milk-protein content, determined as nitrogen content, of less than 100 mg/100 g, usually less than about 20 mg/100 g. Milk serum, however, still contains about 90 % of the water-soluble vitamins, minerals and trace elements present in full milk and therefore is a very desirable basis or additive for nutritional supplementation.
  • lactoserum lactoserum
  • milk serum wherein the lactose that usually is present in an amount of about 90 % of the lactose originally present in milk is destroid, e.g. by cleavage by means of lactase ( ⁇ -galactosidase) .
  • the milk serum may optionally be acidified by lactic acid. While in the scope of the present invention the use of milk serum with less than about 100 mg/lOOg milk-fat and less than about 100 mg/100 g milk-proteins is possible and - since milk serum is e.g.
  • milk serum or whey i.e. milk derived products having higher fat and/or protein content, such as a whey having - in general - about 0.5 % by weight proteins and about 0.1 % by weight fats.
  • the milk serum suitable for being used in the scope of this invention can be produced by ultrafiltration of milk or whey, the lactose can be cleaved by means of lactase, and optionally acidified e.g. by previous fermentation or by addition of acid , in particular lactic acid.
  • Such milk serum can be used as produced, concentrated, dried or rediluted/redissolved.
  • Whey suitable for being used in the scope of the present invention can be obtained by centrifugation and optionally acidified by fermentation or addition of acid (see above) .
  • the aqueous composition is manifested by the features that it comprises at least one in water poorly soluble substance and milk serum or a milk serum comprising substance such as whey. Milk serum or a milk serum comprising substance are also referred to as "milk serum solid comprising”.
  • Such in water poorly soluble substances often do not only strongly adhere to container surfaces but are also oxidation sensitive limiting their storability in contact with water and/or air and/or light, it is preferred that such substances are stored separately, preferably separate from any water comprising medium.
  • Such substances are e.g. fat-soluble vitamins and/or coenzymes.
  • coenzyme QlO One very desirable and critical coenzyme is coenzyme QlO.
  • the aqueous solution of milk serum solids can either be milk serum or whey.
  • Milk serum can be water diluted or non-diluted milk serum as produced or milk serum concentrate, i.e. milk serum with a lower water content than the serum as produced, or it can be rediluted milk serum concentrate or redissolved dried milk serum, whereby the rediluting or the redissolving can be performed with an amount of water leading to a concentration as found in milk serum as produced, or to a lower or higher concentration.
  • a preferred aqueous solution of milk serum solids is selected from milk serum as produced and/or rediluted concentrated milk serum.
  • Whey can be water diluted or non-diluted whey as produced or whey concentrate, i.e. whey with a lower water content than the whey as produced, or it can be rediluted whey concentrate or redissolved dried whey, whereby the rediluting or the redissolving can be performed with an amount of water leading to a concentration as found in whey as produced, or to a lower or higher concentration.
  • a preferred aqueous solution of whey solids is selected from whey as produced and/or rediluted concentrated whey.
  • the component comprising the oxidation sensitive component (s) , the second component is a solid formulation, in particular in the form of a tablet or as granules.
  • a tablet especially a fast disintegrating gas liberating tablet known as effervescent tablets.
  • Such tablets have the advantage that they have a density ensuring that they go to the bottom of the aqueous solution comprising container thereby ensuring that finely powdered poorly wetable substances are not prevented from entering the water bulk due to the high surface tension of the water. Due to the gas liberation, in particular the CO2 liberation, the powdered substances are transported upwards within the aqueous phase and they are thereby distributed within the water phase, making additional mixing by shaking unnecessary.
  • effervescent granules may be used, whereby their density and granule size preferably are chosen such that the above described benefit of effervescent tablets is also obtained.
  • Powders are also possible provided that their composition is such that they penetrate the water surface or that dissolution or dispersion is obtained upon moderate shaking.
  • the milk serum or whey is preferably present in dried form.
  • Such a preparation can either be provided separately, namely as a supplement to tap water or mineral water, or as one component of a two component composition, wherein the other component can be water or an aqueous solution comprising water soluble substances and/or part of the milk serum.
  • any two composition preparations it is also possible to provide a liquid component comprising the poorly water soluble, and in particular also oxidation and/or light sensitive substances with or without milk serum.
  • the number of acceptable solvents is limited by the solubility of the substances and the approval of the solvent for oral uptake.
  • milk serum solids comprising suspensions/solutions can be envisaged. Nevertheless, in view of storage stability, solid preparations are much preferred.
  • solid or concentrated liquid formulations comprising light and/or air sensitive substances with or without milk serum or whey
  • they are packed in light impermeable and preferably also air impermeable one portion packages, in particular in fully metalized, e.g. aluminized, blister packages.
  • fully metalized e.g. aluminized, blister packages.
  • effervescent tablets such tablets are placed between two metalized foils and sealed in a dry atmosphere.
  • compositions of the present invention can be confectioned as functional beverages, i.e. as vitamins and minerals supplemented drinks, as sports drinks etc.
  • the amount of essential substances is in an amount suitable to supplement a usual daily intake.
  • the drinks can also be designed such that they are suitable for prevention of a deficiency or for therapy of a deficiency of essential substances.
  • an object of the present invention is the use of milk serum for enhancing the solubility and/or the dispersibility and/or the re-dipersibility of at least one in water poorly soluble substance in particular substances with the solubility and reactivity/sensitivity of ubiquinone, or a method for enhancing the solubility and/or the dispersibility and/or the re-dipersibility of at least one in water poorly soluble substance, in particular substances with the solubility and reactivity of ubiquinone, by adding milk serum (or milk serum comprising products) to the substance or to the aqueous medium prior to combining the aqueous medium and the poorly water soluble, in particular also oxidation and/or light sensitive substance.
  • a further object of the present invention is a container comprising the inventive two component preparation, said container comprising two compartments and an opening means, said compartments being separated by a wall that can be destroyed/opened by said opening means, said container comprising in a first compartment water or an aqueous solution and in a second compartment a preparation comprising at least one in water poorly soluble substance, said container comprising in the first and/or in the second compartment milk serum, and said two compartments being united due to the operation of the opening means upon the first use of the container such that the contents of the two compartments are combined.
  • a preferred kind of container is e.g. described in more detail in PCT/CH2.005/000596 filed 26 October 2005.
  • Suitable two-compartment containers for use with respective compositions are known in the art, e.g. from WO 98/40289, GB-A-2 321 231, GB-A-2 364 699, WO 2005/009862 and PCT/CH2005/000596.
  • a method is preferred, wherein the bottle body is sealed with a breakable or cuttable foil such as an aluminized or non-metalized plastics foil, e.g. a PET foil, onto which a tablet of the present invention, sealed into a blister, is placed and fixed, e.g. by crimping.
  • a breakable or cuttable foil such as an aluminized or non-metalized plastics foil, e.g. a PET foil, onto which a tablet of the present invention, sealed into a blister, is placed and fixed, e.g. by crimping.
  • medical preparations and their use in prophylaxis and treatment in particular medical preparations for use in the prophylaxis and treatment of deficiency of essential substances.
  • medical preparations for oral administration that comprise poorly water soluble substances and milk serum.
  • compositions are especially suitable for functional drinks .
  • Such drinks e.g. are formed from a tablet comprising
  • essential substances selected from poorly water soluble and/or light and/or air sensitive substances such as vitamins and/or coenzymes, in particular essential substances selected from ubiquinone or ubiquinone comprising substance mixtures,
  • - acidifying agent such as fruit acids, e.g. citric acid, malic acid and mixtures thereof, - a carbon dioxide source such as sodium bicarbonate,
  • - tableting or pelleting aids such as a starch, e.g. corn starch and optionally
  • sweetening agent such as acesulfam K, aspartame etc.
  • colorants
  • the aqueous solution suitable for being combined with such tablet e.g. comprises
  • - milk serum or dissolved milk serum solids or whey or dissolved whey solids, respectively, optionally acidified , e.g. by L ⁇ +) -lactic acid, citric acid, lemon juice or mixtures of two or all of them, in particular a mixture of lactic acid and citric acid or lactic acid and lemon juice, and optionally - sweetening agents
  • Both components can comprise more additional compounds approved for foodstuffs.
  • additional ingredients are such a sugars such as monosaccharides, disaccharides, polysaccharides, e.g. dextrose, fructose and maltodextrin, caffeine, stabilizers, viscosity modifiers, dietary fibers, optionally dried plant extracts etc.
  • compositions for specific performance drinks comprise e.g. the following essential substances and other nutritionally beneficial ingredients :
  • Essential substances Coenzyme QlO, vitamin A, vitamin Bl, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, folic acid, biotin, pantothenic acid, calcium, iron, magnesium, selenium, zinc
  • E calcium, magnesium Solution: Milk serum (lactose-free, acidified) , maltodextrin, fructose, dextrose, L-carnitin
  • Vitamins, minerals and trace elements in general are comprised in the drink in such amounts that • about half a liter of drink provides about 15 to 100 %, preferably about 30 to 40 % of the generally recommended daily dose. For specific drinks, however, higher doses of ⁇ 50 % of the recommended daily dose may be preferred, e.g. for minerals such as Ca and Mg, or for vitamins such as vitamin C. In order to favor the absorption of the minerals absorption favoring substances may be added.
  • the recommended daily intake of some vitamins, minerals and trace elements is:
  • Vitamin A about 800 ⁇ g, vitamin Bl about 1.4 mg, vitamin B2 about 1.6 mg, vitamin B6 about 2 mg, vitamin B12 about 1 ⁇ g, vitamin C about 60 mg, vitamin D about 5 ⁇ g, vitamin E about 10 mg, folic acid about 200 ⁇ g, biotin about 0.15 mg, pantothenic acid about 6 mg, calcium about 800 mg, iron about 1.5 mg, magnesium about 300 mg, selenium about 50 ⁇ g, and zinc about 15 mg.
  • coenzyme QlO 30 to 35 mg/500 ml is preferred, for caffeine 80 to 90 mg/500 ml and for L- carnitin 250 to 350 mg/500 ml.
  • the carbohydrate content is enhanced by addition of sugars (including maltodextrin) .
  • sugars including maltodextrin
  • the sugars, in particular fructose and dextrose are added in amounts of about 3 g per 500 ml, maltodextrin in an amount of about 1 g per 500 ml.
  • a milk serum with a solid concentration as produced is suitable.
  • Such milk serum preferably is acidified and lactose-free and may be obtained by ultrafiltration through a membrane with a molecular weight cut-off of 10000 kDa, e.g.
  • It may be used as produced or be a rediluted milk serum concentrate or a redissolved dried milk serum, whereby, however, the dried milk serum due to the energy needed for full drying is less preferred.
  • a suitable milk serum basis has the following product specification (per 100 ml) :
  • Carbohydrates 3.0 g (all sugars, namely 1.5 g dextrose, 1.5 g galactose, 0.0 g lactose)
  • Fats below 100 mg, preferably below 50 mg
  • Lactic acid 0.05 - 0.3 g
  • a suitable effervescent tablet may be pleasantly colored to get an optical effect during the dissolution.
  • the tablet may be homogeneously colored or be a two or more phase tablet having different colors. Since several desirable ingredients are colored themselves, but resulting in an unpleasant color, colorants are preferably added at least to that phase of the tablet comprising colored ingredients. In the case of two or more phase tablets, the several phases may be layered or homogeneously mixed with each other.
  • a tablet suitable for use in the scope of the present invention can be produced according to any method suitable for the production of vitamins, especially oxygen and light sensitive vitamins comprising effervescent tablets, by preparing a pre-mix comprising all ingredients and then pressing said premix according to methods well known to the skilled person.
  • the carbon dioxide generated by each tablet in water or in aqueous solution can be regulated by the carbonate content and the acid content and the acidity of the acid component, advantageously is above 1.5 g/liter, preferably in the range of 1.5. to 3.0 g per liter, and most preferred in the range of 1.7 - 1.9 g/liter.
  • Such milk serum comprising basic drink, i.e. without carbohydrate or fat content influencing substances, has the following nutritional values (per 100 ml) : Energy value: about 51 kJ or 12 kcal
  • milk serum concentrations as low as about 1.5 % are still able to dissolve or homogeneously disperse the coenzyme QlO.
  • Example 2 The solubility of QlO powder in different aqueous solutions was tested. For each solution, the identical procedure was applied. The results are listed in Table 2. As can be seen from Samples I and J, the adhesion of the QlO powder at the bottle walls is markedly reduced by the milk serum addition.
  • Example 3 The effect of additional fat or albumin on the solubility of QlO powder and an effervescent tablet (see Example 4) was tested.
  • the Process applied for samples P and Q and for samples R and S were identical. Samples P and Q were produced by heating to 60 0 C, adding the fat, cooling to 35°C, and then adding QlO. Samples R and S were produced by heating to 60 0 C, adding the protein, cooling to 10 0 C, and then adding QlO, The results are listed in Table 3. They show the benefit obtained by adding the coenzyme QlO by means of an effervescent tablet.
  • a drink rich in vitamins, minerals and trace elements is produced by providing 470 ml of a solution comprising a milk serum basis in a concentration as produced, with a solids content of 3.2 +/- 0.2 %, a glucose content of 1.5 %, a galactose content of 1.5 %, a fat content of ⁇ 100 mg, a protein content of ⁇ 100 mg, a lactic acid content of 0.1 %, a minerals content of 0.2 %, and a pH of 4.5 +/-0.2 %. in a sterile container filled under sterile conditions and sealed with a breakable or cuttable foil and providing an effervescent tablet with a weight of 5.7 g and having the following composition:
  • the tablet is sealed in an aluminized blister and then placed onto the seal of the bottle neck and crimped. Finally, the bottle is closed with a bottle cover including an opening means for destroying the bottle neck sealing foil, thereby liberating the tablet such that it can fall (or is pushed) into the solution within the bottle body upon the first intended use of the bottle (see also PCT/CH2005/000596 for a more detailed description) .
  • the bottle cover preferably is a "sports cap", i.e. a cover with a re-closable drinking opening and said cover is unremovably fixed to the neck of the bottle body.

Abstract

Described is an aqueous composition comprising at least one in water poorly soluble and/or poorly wetable substance, in particular coenzyme Q10, and milk serum. Said aqueous composition preferably is a two component composition, with a coenzyme Q10 comprising effervescent tablet and a milk serum solution, said two components being contained in a container comprising two compartments and an opening means, said compartments being separated by a wall that can be destroyed/opened by said opening means such that upon manipulating the opening means as intended the tablet falls into the solution thereby forming the desired beverage.

Description

Milk serum supplemented aqueous solutions
Technical Field
The present invention concerns milk serum (lactoserum) comprising aqueous solutions supplemented with poorly water soluble or water insoluble and/or poorly water wetable or water non-wetable and possibly also oxidation sensitive ingredients such as hydrophobic vitamins and coenzymes, in particular ubiquinones, especially coenzyme QlO.
Background Art
Due to their nutritional behavior, some people do not have a sufficient intake of essential substances such as e.g. vitamins, minerals, trace elements and coenzymes. 'In particular in diet poor in vegetable and fruit, but also in diet reduced in fat, the uptake of fat soluble vitamins and other essential or ' desirable substances is insufficient. Therefore several preparations are found on the market that provide such substances .
Vitamins comprising preparations are e.g. vitamins supplemented energy drinks . Such drinks comprise e.g. water soluble vitamins and water-soluble derivatives of fat-soluble vitamins and minerals. A disadvantage of such drinks is that - due to the instability of many vitamins in contact with humidity and/or oxygen and/or light, necessitating to add a surplus of them to ensure the declared amount at the end of the marked storage time. Thus, as an alternative and in particular also for fat-soluble substances for which no suitable water soluble derivatives are known, alternative or usual preparations are in the form of water disintegrating tablets, in particular effervescent tablets, or, especially for water insoluble substances, in the form of capsules .
BESTATIGUNGSKOPIE One of the water insoluble or at most poorly soluble substances for which no water soluble effective derivative is known is coenzyme QlO (also referred to as QlO only), respectively. Coenzyme QlO is an essential component of cellular energy metabolism, in particular respiration, and thus is a very desirable ingredient in preparations intended for active people or in preparations intended as nutritional supplements to improve the health status and the vitality of people in need thereof.
Besides of its poor water solubility, a further problem with ubiquinone comprising preparations is their oxidation sensitivity strongly affecting their storage stability. While for poorly water soluble and oxidation sensitive substances the total uptake is no problem if consumed in form of a capsule intended to be consumed as a whole, tablets to be dissolved have the disadvantage that upon dissolution or rather disintegration in water the water insoluble and/or poorly wetable ingredients have the tendency to deposit and/or adhere to the walls of the glass or other drinking container. In such case, the amount of substance actually consumed is unpredictable and may to a high extent depend on the time elapsed between the disintegration of the tablet and the actual time of consumption, the more so since many people prefer to take few sips several times during a certain time than a whole glass at once.
In addition, the poor storage stability of depositing and/or oxidation and/or light sensitive substances in aqueous environment makes them unsuitable for aqueous formulations such as ready to consume functional drinks .
Thus, there is still a need for storage stable, aqueous preparations comprising poorly water soluble and/or poorly water wetable substances that may also be oxidation and/or light sensitive. Disclosure of the Invention
Hence, it is a general object of the invention to provide a composition that does not have the above mentioned disadvantages, but enables the production of aqueous solutions and/or suspensions with enhanced storage stability and reduced adherence of the poorly water soluble and/or poorly water wetable substances on the container walls.
In the scope of this invention, reference to substances that in water are poorly soluble (poorly water soluble substances) also includes substances that are insoluble in water (water insoluble substances) , substances that are poorly wetted by water (poorly water wetable substances) and substances that are not wetted by water (not water wetable substances) . Poorly water soluble means that the respective substance has a solubility in water at 5°C of less than 10 mg/100 ml, in general less than 7 mg/100 ml. The invention, however, is much advantageous in connection with substances having a solubility of less than 5 mg/100 ml or even an as low solubility as less than 3 or even 2 mg/100 ml. It has now surprisingly be found that milk serum (lactoserum) is a very efficient medium to improve the solubility or dispersibility and the wetability of lipophilic/hydrophobic substances .
In connection with this invention, the term milk serum or lactoserum, respectively, is not used as synonym to whey but means the liquid resulting after removal of the proteins and the fats from milk or whey.
Milk serum suitable for use in the present invention may be non-acidic, acidic (e.g. obtained from sour-whey) or acidified. While whey in general still comprises about 20% of the originally present milk proteins, the milk serum (lactoserum) in general has a milk-fat content of less than 100 mg/100 g, usually less than about 50 mg/100 g, and a milk-protein content, determined as nitrogen content, of less than 100 mg/100 g, usually less than about 20 mg/100 g. Milk serum, however, still contains about 90 % of the water-soluble vitamins, minerals and trace elements present in full milk and therefore is a very desirable basis or additive for nutritional supplementation. Due to lactose intolerance of many people, it might be favorable to use a milk serum wherein the lactose that usually is present in an amount of about 90 % of the lactose originally present in milk is destroid, e.g. by cleavage by means of lactase (β-galactosidase) . In addition, the milk serum may optionally be acidified by lactic acid. While in the scope of the present invention the use of milk serum with less than about 100 mg/lOOg milk-fat and less than about 100 mg/100 g milk-proteins is possible and - since milk serum is e.g. the off- product of cheese production where an almost entire fat and protein withdrawal is desirable - preferred, the invention also works with milk serum or whey, i.e. milk derived products having higher fat and/or protein content, such as a whey having - in general - about 0.5 % by weight proteins and about 0.1 % by weight fats.. The milk serum suitable for being used in the scope of this invention can be produced by ultrafiltration of milk or whey, the lactose can be cleaved by means of lactase, and optionally acidified e.g. by previous fermentation or by addition of acid , in particular lactic acid. Such milk serum can be used as produced, concentrated, dried or rediluted/redissolved.
Whey suitable for being used in the scope of the present invention can be obtained by centrifugation and optionally acidified by fermentation or addition of acid (see above) .
Now, in order to implement these and still further objects of the invention, which will become more readily apparent as the description proceeds, the aqueous composition is manifested by the features that it comprises at least one in water poorly soluble substance and milk serum or a milk serum comprising substance such as whey. Milk serum or a milk serum comprising substance are also referred to as "milk serum solid comprising".
Since such in water poorly soluble substances often do not only strongly adhere to container surfaces but are also oxidation sensitive limiting their storability in contact with water and/or air and/or light, it is preferred that such substances are stored separately, preferably separate from any water comprising medium. Such substances are e.g. fat-soluble vitamins and/or coenzymes. One very desirable and critical coenzyme is coenzyme QlO.
In view of the above mentioned sensitivities, for good storage stability, it is desired to keep the sensitive components under conditions wherein their ^ reactivity/disintegration is reduced or, preferably, prevented, and to combine them immediately prior to use. This can be achieved with a two component composition, wherein one component comprises an aqueous solution of milk serum solids and optionally further water soluble substances such as water soluble vitamins and the second component comprises the in water poorly soluble and optionally oxygen and/or light sensitive substances.
The aqueous solution of milk serum solids can either be milk serum or whey. Milk serum can be water diluted or non-diluted milk serum as produced or milk serum concentrate, i.e. milk serum with a lower water content than the serum as produced, or it can be rediluted milk serum concentrate or redissolved dried milk serum, whereby the rediluting or the redissolving can be performed with an amount of water leading to a concentration as found in milk serum as produced, or to a lower or higher concentration. A preferred aqueous solution of milk serum solids is selected from milk serum as produced and/or rediluted concentrated milk serum.
Whey can be water diluted or non-diluted whey as produced or whey concentrate, i.e. whey with a lower water content than the whey as produced, or it can be rediluted whey concentrate or redissolved dried whey, whereby the rediluting or the redissolving can be performed with an amount of water leading to a concentration as found in whey as produced, or to a lower or higher concentration. A preferred aqueous solution of whey solids is selected from whey as produced and/or rediluted concentrated whey.
For good storage stability, it is preferred that the component comprising the oxidation sensitive component (s) , the second component, is a solid formulation, in particular in the form of a tablet or as granules. Presently preferred is a tablet, especially a fast disintegrating gas liberating tablet known as effervescent tablets. Such tablets have the advantage that they have a density ensuring that they go to the bottom of the aqueous solution comprising container thereby ensuring that finely powdered poorly wetable substances are not prevented from entering the water bulk due to the high surface tension of the water. Due to the gas liberation, in particular the CO2 liberation, the powdered substances are transported upwards within the aqueous phase and they are thereby distributed within the water phase, making additional mixing by shaking unnecessary. In stead of tablets also effervescent granules may be used, whereby their density and granule size preferably are chosen such that the above described benefit of effervescent tablets is also obtained. Powders are also possible provided that their composition is such that they penetrate the water surface or that dissolution or dispersion is obtained upon moderate shaking. Besides of the two component composition described above, it is also possible to add at least part of the milk serum or whey to the at least one in water poorly soluble substance. In such a composition, the milk serum or whey is preferably present in dried form. Such a preparation can either be provided separately, namely as a supplement to tap water or mineral water, or as one component of a two component composition, wherein the other component can be water or an aqueous solution comprising water soluble substances and/or part of the milk serum.
In any two composition preparations it is also possible to provide a liquid component comprising the poorly water soluble, and in particular also oxidation and/or light sensitive substances with or without milk serum. However, the number of acceptable solvents is limited by the solubility of the substances and the approval of the solvent for oral uptake. For substances that are sufficiently stable in water in the absence of air and/or light, also concentrated, milk serum solids comprising suspensions/solutions can be envisaged. Nevertheless, in view of storage stability, solid preparations are much preferred.
For all solid or concentrated liquid formulations comprising light and/or air sensitive substances with or without milk serum or whey, it is preferred that they are packed in light impermeable and preferably also air impermeable one portion packages, in particular in fully metalized, e.g. aluminized, blister packages. In view of the humidity sensitivity of effervescent tablets, such tablets are placed between two metalized foils and sealed in a dry atmosphere.
The compositions of the present invention can be confectioned as functional beverages, i.e. as vitamins and minerals supplemented drinks, as sports drinks etc. In such drinks, the amount of essential substances is in an amount suitable to supplement a usual daily intake. The drinks, however, can also be designed such that they are suitable for prevention of a deficiency or for therapy of a deficiency of essential substances.
The benefit of the milk serum is that many poorly water soluble substances can be dissolved or finely and homogeneously dispersed. In addition, deposits that might be observed after a longer storage time can easily be removed from the container wall and redispersed several times. Also an object of the present invention is the use of milk serum for enhancing the solubility and/or the dispersibility and/or the re-dipersibility of at least one in water poorly soluble substance in particular substances with the solubility and reactivity/sensitivity of ubiquinone, or a method for enhancing the solubility and/or the dispersibility and/or the re-dipersibility of at least one in water poorly soluble substance, in particular substances with the solubility and reactivity of ubiquinone, by adding milk serum (or milk serum comprising products) to the substance or to the aqueous medium prior to combining the aqueous medium and the poorly water soluble, in particular also oxidation and/or light sensitive substance.
A further object of the present invention is a container comprising the inventive two component preparation, said container comprising two compartments and an opening means, said compartments being separated by a wall that can be destroyed/opened by said opening means, said container comprising in a first compartment water or an aqueous solution and in a second compartment a preparation comprising at least one in water poorly soluble substance, said container comprising in the first and/or in the second compartment milk serum, and said two compartments being united due to the operation of the opening means upon the first use of the container such that the contents of the two compartments are combined. A preferred kind of container is e.g. described in more detail in PCT/CH2.005/000596 filed 26 October 2005.
Suitable two-compartment containers for use with respective compositions are known in the art, e.g. from WO 98/40289, GB-A-2 321 231, GB-A-2 364 699, WO 2005/009862 and PCT/CH2005/000596.
In order to meet high purity standards, a method is preferred, wherein the bottle body is sealed with a breakable or cuttable foil such as an aluminized or non-metalized plastics foil, e.g. a PET foil, onto which a tablet of the present invention, sealed into a blister, is placed and fixed, e.g. by crimping.
Also encompassed by the present invention are medical preparations and their use in prophylaxis and treatment, in particular medical preparations for use in the prophylaxis and treatment of deficiency of essential substances. In particular comprised in the present invention are also medical preparations for oral administration that comprise poorly water soluble substances and milk serum.
Modes for Carrying out the Invention While medical preparations and their use in prophylaxis and treatment, e.g. for the prophylaxis and treatment of deficiency of essential substances are also encompassed by the present invention, the compositions are especially suitable for functional drinks .
Such drinks e.g. are formed from a tablet comprising
- essential substances selected from poorly water soluble and/or light and/or air sensitive substances such as vitamins and/or coenzymes, in particular essential substances selected from ubiquinone or ubiquinone comprising substance mixtures,
- acidifying agent such as fruit acids, e.g. citric acid, malic acid and mixtures thereof, - a carbon dioxide source such as sodium bicarbonate,
- tableting or pelleting aids such as a starch, e.g. corn starch and optionally
- minerals and trace elements
- aroma
- sweetening agent such as acesulfam K, aspartame etc. - colorants
The aqueous solution suitable for being combined with such tablet e.g. comprises
- milk serum or dissolved milk serum solids, or whey or dissolved whey solids, respectively, optionally acidified , e.g. by L {+) -lactic acid, citric acid, lemon juice or mixtures of two or all of them, in particular a mixture of lactic acid and citric acid or lactic acid and lemon juice, and optionally - sweetening agents
- water soluble as well as air and light stable vitamins, minerals and trace elements
- aromas
- colorants. Both components can comprise more additional compounds approved for foodstuffs. Examples of additional ingredients are such a sugars such as monosaccharides, disaccharides, polysaccharides, e.g. dextrose, fructose and maltodextrin, caffeine, stabilizers, viscosity modifiers, dietary fibers, optionally dried plant extracts etc.
Dependent on the intended use of the beverage, different essential substances or rather compositions of essential substances can be added to either the tablet or to the aqueous solution. Such essential substances comprise but are not limited to substances selected from the group comprising ubiquinone, vitamin A, vitamin Bl, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, folic acid, biotin, pantothenic acid, calcium, iron, magnesium, selenium, zinc, L-carnitin, and mixtures thereof. While it is preferred to have also the water- soluble light and air sensitive substances in the tablet, it is also possible to put such substances in the aqueous solution, provided that the solution containing container is air and light tight, e.g. aluminized. Preferred compositions for specific performance drinks comprise e.g. the following essential substances and other nutritionally beneficial ingredients :
Multi-Vitamin:
Tablet:
Essential substances: Coenzyme QlO, vitamin A, vitamin Bl, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, folic acid, biotin, pantothenic acid, calcium, iron, magnesium, selenium, zinc
Solution:
Milk serum (lactose-free, acidified)
Energy and Brain:
Tablet:
Essential substances: Coenzyme QlO, vitamin Bl, vitamin B2, vitamin B6, vitamin E
Solution: Milk serum (lactose-free, acidified) , fructose, dextrose, caffeine
Sport and Body:
Tablet: Essential substances: Coenzyme QlO, vitamin
E, calcium, magnesium Solution: Milk serum (lactose-free, acidified) , maltodextrin, fructose, dextrose, L-carnitin
Mineral Ca, Mg: Tablet:
Essential substances: Coenzyme QlO, vitamine C, vitamin D, vitamin E, calcium, magnesium Solution:
Milk serum (lactose-free, acidified)
Vitamins, minerals and trace elements in general are comprised in the drink in such amounts that • about half a liter of drink provides about 15 to 100 %, preferably about 30 to 40 % of the generally recommended daily dose. For specific drinks, however, higher doses of ≥ 50 % of the recommended daily dose may be preferred, e.g. for minerals such as Ca and Mg, or for vitamins such as vitamin C. In order to favor the absorption of the minerals absorption favoring substances may be added. The recommended daily intake of some vitamins, minerals and trace elements is:
Vitamin A about 800 μg, vitamin Bl about 1.4 mg, vitamin B2 about 1.6 mg, vitamin B6 about 2 mg, vitamin B12 about 1 μg, vitamin C about 60 mg, vitamin D about 5 μg, vitamin E about 10 mg, folic acid about 200 μg, biotin about 0.15 mg, pantothenic acid about 6 mg, calcium about 800 mg, iron about 1.5 mg, magnesium about 300 mg, selenium about 50 μg, and zinc about 15 mg. For coenzyme QlO, 30 to 35 mg/500 ml is preferred, for caffeine 80 to 90 mg/500 ml and for L- carnitin 250 to 350 mg/500 ml.
For drinks intended to provide energy, the carbohydrate content is enhanced by addition of sugars (including maltodextrin) . The sugars, in particular fructose and dextrose are added in amounts of about 3 g per 500 ml, maltodextrin in an amount of about 1 g per 500 ml. For sufficiently dissolving/dispersing the above mentioned ingredients, a milk serum with a solid concentration as produced is suitable. Such milk serum preferably is acidified and lactose-free and may be obtained by ultrafiltration through a membrane with a molecular weight cut-off of 10000 kDa, e.g. a membrane obtainable from Danish Separation Systems AS, Stavangervej 10, DK-4900 Nakskov, as DSS Flat Sheet Memebranes type GR, in particular a membrane type GR81PP, followed by lactase treatment, and acidification by adding about 0.05 - 0.3 % lactic acid to the milk serum after ultrafiltration, preferably prior to lactase treatment. It may be used as produced or be a rediluted milk serum concentrate or a redissolved dried milk serum, whereby, however, the dried milk serum due to the energy needed for full drying is less preferred.
A suitable milk serum basis has the following product specification (per 100 ml) :
Energy value: 51 kJ (12 kcal) ■ Proteins: below 100 mg, preferably below 50 mg, or even below 20 mg
Carbohydrates: 3.0 g (all sugars, namely 1.5 g dextrose, 1.5 g galactose, 0.0 g lactose)
Fats: below 100 mg, preferably below 50 mg
Lactic acid: 0.05 - 0.3 g
Minerals: 0.2 g
Dry substance: 3.2 +/- 0.2 g
A suitable effervescent tablet may be pleasantly colored to get an optical effect during the dissolution. The tablet may be homogeneously colored or be a two or more phase tablet having different colors. Since several desirable ingredients are colored themselves, but resulting in an unpleasant color, colorants are preferably added at least to that phase of the tablet comprising colored ingredients. In the case of two or more phase tablets, the several phases may be layered or homogeneously mixed with each other.
A tablet suitable for use in the scope of the present invention can be produced according to any method suitable for the production of vitamins, especially oxygen and light sensitive vitamins comprising effervescent tablets, by preparing a pre-mix comprising all ingredients and then pressing said premix according to methods well known to the skilled person. The carbon dioxide generated by each tablet in water or in aqueous solution can be regulated by the carbonate content and the acid content and the acidity of the acid component, advantageously is above 1.5 g/liter, preferably in the range of 1.5. to 3.0 g per liter, and most preferred in the range of 1.7 - 1.9 g/liter.
Such milk serum comprising basic drink, i.e. without carbohydrate or fat content influencing substances, has the following nutritional values (per 100 ml) : Energy value: about 51 kJ or 12 kcal
Proteins: below 0.1 g Carbohydrates : about 3 g Fat: below 0.1 g
Examples :
Example 1:
The solubilizing effect of milk serum on QlO powder at different concentrations was tested. For each solution, the identical procedure was applied. The results are listed in Table 1.
As can be seen from these results milk serum concentrations as low as about 1.5 % are still able to dissolve or homogeneously disperse the coenzyme QlO.
Example 2 : The solubility of QlO powder in different aqueous solutions was tested. For each solution, the identical procedure was applied. The results are listed in Table 2. As can be seen from Samples I and J, the adhesion of the QlO powder at the bottle walls is markedly reduced by the milk serum addition.
Example 3 : The effect of additional fat or albumin on the solubility of QlO powder and an effervescent tablet (see Example 4) was tested. The Process applied for samples P and Q and for samples R and S were identical. Samples P and Q were produced by heating to 600C, adding the fat, cooling to 35°C, and then adding QlO. Samples R and S were produced by heating to 600C, adding the protein, cooling to 100C, and then adding QlO, The results are listed in Table 3. They show the benefit obtained by adding the coenzyme QlO by means of an effervescent tablet.
Table 1
en
Figure imgf000017_0001
Remarks: To all samples one effervescent tablet type Multi-Vitamin (see example 4] was added
Table 2
Figure imgf000018_0001
Table 3
Figure imgf000019_0001
Example 4 :
A drink rich in vitamins, minerals and trace elements is produced by providing 470 ml of a solution comprising a milk serum basis in a concentration as produced, with a solids content of 3.2 +/- 0.2 %, a glucose content of 1.5 %, a galactose content of 1.5 %, a fat content of < 100 mg, a protein content of < 100 mg, a lactic acid content of 0.1 %, a minerals content of 0.2 %, and a pH of 4.5 +/-0.2 %. in a sterile container filled under sterile conditions and sealed with a breakable or cuttable foil and providing an effervescent tablet with a weight of 5.7 g and having the following composition:
- vitamin A 267 μg
- vitamin D3 1.65 μg
- vitamin Bl 0.47 mg
- vitamin B2 0.53 mg - vitamin B6 0.67 mg
- pantothenic acid 2. 0 mg
- vitamin B12 0. 33 μg
- biotin 50 μg
- folic acid 67 μg - vitamin C 20.0 mg
- vitamin E 3.3 mg
- calcium (as carbonate) 167 mg
- iron (as iron (II) gluconattee) ) 4.7 mg
- magnesium (as carbonate) 81 mg - selenium (as sodium selenittee) ) 16.0 μg
- zinc (as sulfate) 5.0 mg
- coenzyme QlO 30 mg
- citric acid 3.2 g
- sodium bicarbonate 1.4 g - corn starch 0.4 G
- aromatics, sweetener (acesulfam K, aspartame), and colorants together < 0.1 g The ingredients are mixed tableted in a dry atmosphere .
Still in dry atmosphere, the tablet is sealed in an aluminized blister and then placed onto the seal of the bottle neck and crimped. Finally, the bottle is closed with a bottle cover including an opening means for destroying the bottle neck sealing foil, thereby liberating the tablet such that it can fall (or is pushed) into the solution within the bottle body upon the first intended use of the bottle (see also PCT/CH2005/000596 for a more detailed description) .
The bottle cover preferably is a "sports cap", i.e. a cover with a re-closable drinking opening and said cover is unremovably fixed to the neck of the bottle body.
While there are shown and described presently preferred embodiments of the invention, it is to be dis- tinctly understood that the invention is not limited thereto but may be otherwise variously embodied and practiced within the scope of the following claims.

Claims

Claims
1. An aqueous composition comprising at least one in water poorly soluble substance and milk serum solids .
2. The composition of claim 1, wherein the at least one of the in water poorly soluble substances is also oxidation and/or light sensitive.
3. The composition of claim 1 or 2, wherein the at least one in water poorly soluble substance is selected from fat-soluble vitamins and/or coenzymes .
4. The composition of anyone of the preceding claims wherein the at least one in water poorly soluble substance comprises an ubiquinone, in particular coenzyme QlO.
5. The composition of anyone of the preceding claims which is a two component composition wherein one component comprises an aqueous solution of milk serum solids and the second component comprises the in water poorly soluble substances .
6. The composition of claim 5, wherein the aqueous solution of milk serum solids is selected from milk serum as produced or rediluted concentrated milk serum or redissolved dried milk serum or from whey as produced or from rediluted concentrated whey or redissolved dried whey.
7. The composition of claim 5 or 6, wherein the aqueous solution of milk serum solids is selected from milk serum as produced or rediluted concentrated milk serum or redissolved dried milk serum.
8. The composition of anyone of claims 5 to 1, wherein the second component is a solid formulation, in particular in the form of a tablet or as granules .
9. The composition of claim 8, wherein the solid formulation is an effervescent tablet or effervescent granules .
10. The composition of claim 8 or 9, wherein the solid formulation is an effervescent tablet.
11. The composition of anyone of claims 1 to 4, which is a two component composition wherein one component is water or an aqueous solution and the second component comprises the at least one in water poorly soluble substance and milk serum solids.
12. The composition of claim 11, wherein the second component is a solid preparation and the milk serum solids are dried milk serum or dried whey.
13. The composition of claim 11 or 12, wherein the second component is a solid preparation and the milk serum solids are dried milk serum.
14. A solid preparation comprising milk serum solids and at least one in water poorly soluble substance .
15. The solid preparation of claim 14, wherein the at least one in water poorly soluble substance is an ubiquinone or an ubiquinone comprising substance mixture, in particular a coenzyme QlO or a coenzyme QlO comprising substance mixture.
16. The solid preparation of anyone of claims 14 to 15, wherein the milk serum solids are dried milk serum or dried whey.
17. The solid preparation of anyone of claims
14 to 16, wherein the milk serum solids are dried milk serum.
18. The solid preparation of anyone of claims 14 to 17 which is an effervescent tablet.
19. Use of milk serum solids for enhancing the solubility and/or the dispersibility and/or the re- dipersibility of at least one in water poorly soluble substance, in particular an ubiquinone, especially coenzyme QlO.
20. The use of claim 19, wherein the milk serum solids are dried milk serum or dried whey.
21. The use of claim 19 or 20, wherein the milk serum solids are dried milk serum.
22. A container comprising two compartments and an opening means, said compartments being separated by a wall that can be destroyed/opened by said opening means, said container comprising in a first compartment water or an aqueous solution and, in a second compartment, a preparation comprising at least one in water poorly soluble substance, said container comprising in the first and/or in the second compartment milk serum, and said two compartments being united due to the operation of the opening means upon the first use of the container such that the contents of the two compartments are combined.
PCT/CH2006/000211 2006-04-19 2006-04-19 Milk serum supplemented aqueous solutions WO2007118338A1 (en)

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