WO2007103523A3 - Antioxidant protein, compositions, and methods of use - Google Patents
Antioxidant protein, compositions, and methods of use Download PDFInfo
- Publication number
- WO2007103523A3 WO2007103523A3 PCT/US2007/005968 US2007005968W WO2007103523A3 WO 2007103523 A3 WO2007103523 A3 WO 2007103523A3 US 2007005968 W US2007005968 W US 2007005968W WO 2007103523 A3 WO2007103523 A3 WO 2007103523A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- oxidative stress
- present
- antioxidant protein
- provides
- antioxidant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present invention provides a novel antioxidant protein (SAOP) comprising a MOCO Sulfurase C-terminal Domain (MOSC), which may be secreted and which has antioxidant activity, as demonstrated by its ability to protect cultured cells from oxidative stress, and by its ability to increase GSH concentration. The present invention also provides polynucleotides encoding the antioxidant protein, as well as vectors containing the polynucleotide under control of regulatory sequences, and corresponding host cells. The present invention also provides a composition comprising an effective amount of the antioxidant protein with a pharmaceutically acceptable carrier or excipient. The composition finds use in ameliorating oxidative stress in a mammal, and thus is useful for treating conditions characterized by or associated with oxidative stress. The present invention further provides an antibody or antigen-binding fragment that binds specifically to the antioxidant protein of the invention, which finds use in various diagnostic applications for oxidative stress.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78032506P | 2006-03-08 | 2006-03-08 | |
US60/780,325 | 2006-03-08 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2007103523A2 WO2007103523A2 (en) | 2007-09-13 |
WO2007103523A3 true WO2007103523A3 (en) | 2008-02-21 |
WO2007103523A9 WO2007103523A9 (en) | 2008-04-10 |
Family
ID=38475572
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/005968 WO2007103523A2 (en) | 2006-03-08 | 2007-03-08 | Antioxidant protein, compositions, and methods of use |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2007103523A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104059956B (en) * | 2014-06-16 | 2018-04-10 | 西北民族大学 | A kind of preparation method for hiding antioxidation polypeptide in sheep blood |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040034192A1 (en) * | 2000-01-06 | 2004-02-19 | Seishi Kato | Human proteins having hyprophobic domains and dnas encoding these proteins |
-
2007
- 2007-03-08 WO PCT/US2007/005968 patent/WO2007103523A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040034192A1 (en) * | 2000-01-06 | 2004-02-19 | Seishi Kato | Human proteins having hyprophobic domains and dnas encoding these proteins |
Also Published As
Publication number | Publication date |
---|---|
WO2007103523A9 (en) | 2008-04-10 |
WO2007103523A2 (en) | 2007-09-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2532365A4 (en) | Pharmaceutical composition for treatment and/or prevention of cancer | |
WO2005103083A3 (en) | Anti-cd38 human antibodies and uses therefor | |
EP2532366A4 (en) | Pharmaceutical composition for treating and/or preventing cancer | |
SA517390230B1 (en) | RGMA Binding Protein and Use Thereof | |
MX351682B (en) | Pharmaceutical composition for treatment and/or prophylaxis of cancer. | |
EP3144323A3 (en) | Anti-c4.4a antibodies and uses thereof | |
WO2009103105A3 (en) | Mimotopes of alpha-synuclein and vaccines thereof for the treatment of neurodegenerative disorders | |
MX340015B (en) | Pharmaceutical composition for treatment and/or prevention of cancer. | |
MX340016B (en) | Pharmaceutical composition for treatment and/or prevention of cancer. | |
MX351414B (en) | Pharmaceutical composition for treatment and/or prevention of pancreatic cancer. | |
MX2009004532A (en) | Compositions and methods for binding sphingosine-1-phosphate. | |
WO2010034032A3 (en) | Methods for preparing purified polypeptide compositions | |
MX371442B (en) | Fcyriib-specific fc region variant. | |
WO2007024535A3 (en) | Antagonist antibodies against gdf-8 and uses in treatment of als and other gdf-8-associated disorders | |
UA106079C2 (en) | Normal;heading 1;heading 2;heading 3;APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | |
WO2006105021A3 (en) | Gitr binding molecules and uses therefor | |
BRPI0518675A2 (en) | polypeptide, polynucleotide, vector, composition, use of peptide or polypeptide, methods of treating or ameliorating sepsis, septic shock or conditions similar to sepsis in an individual, and screening compounds or compositions for treating sepsis, septic shock or the like sepsis and vector use | |
WO2007042309A3 (en) | Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human cd38 | |
UA113397C2 (en) | PREVENTION OF ADVERSE EFFECTS CAUSED BY SPECIFIC DOMAINS OF CD3 BINDING | |
WO2012160563A3 (en) | Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same | |
NZ733026A (en) | Mutant fragments of ospa and methods and uses relating thereto | |
BR112012004697A2 (en) | enhanced protein purification by elution of the modified a protein. | |
WO2011017132A3 (en) | Mk2 inhibitor compositions and methods to enhance neurite outgrowth, neuroprotection, and nerve regeneration | |
WO2009052489A3 (en) | Novel inhibitors of mammalian tight junction opening | |
WO2012012712A3 (en) | Tricyclic proteasome activity enhancing compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 07752652 Country of ref document: EP Kind code of ref document: A2 |