WO2007103135A3 - Active cell growth substrates and uses thereof - Google Patents

Active cell growth substrates and uses thereof Download PDF

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Publication number
WO2007103135A3
WO2007103135A3 PCT/US2007/005291 US2007005291W WO2007103135A3 WO 2007103135 A3 WO2007103135 A3 WO 2007103135A3 US 2007005291 W US2007005291 W US 2007005291W WO 2007103135 A3 WO2007103135 A3 WO 2007103135A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell
vitro
polymer
growth
substrate
Prior art date
Application number
PCT/US2007/005291
Other languages
French (fr)
Other versions
WO2007103135A2 (en
Inventor
Michael P Sheetz
James C Hone
Monica Tanase
Samuel J Wind
Original Assignee
Univ Columbia
Michael P Sheetz
James C Hone
Monica Tanase
Samuel J Wind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia, Michael P Sheetz, James C Hone, Monica Tanase, Samuel J Wind filed Critical Univ Columbia
Publication of WO2007103135A2 publication Critical patent/WO2007103135A2/en
Publication of WO2007103135A3 publication Critical patent/WO2007103135A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides

Abstract

The present invention provides for a cell growth substrate, wherein the substrate comprises a growth medium and a cross-linked polymer, wherein increased strain on the polymer does not substantially increase rigidity of the polymer, and wherein the polymer has an elastic modulus (E) of about 0.1 kPa to about 10.0 kPa. An apparatus for applying a perturbation to a cell in vitro is also provided, wherein the apparatus comprises the cell growth substrate and an external force generator associated with the substrate. The invention further provides methods for stimulating growth of a cell in vitro, cell differentiation in vitro, and a cellular response in vitro, for promoting growth of a cell in vivo, for treating a wound.
PCT/US2007/005291 2006-03-02 2007-03-02 Active cell growth substrates and uses thereof WO2007103135A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77933706P 2006-03-02 2006-03-02
US60/779,337 2006-03-02
US88139007P 2007-01-19 2007-01-19
US60/881,390 2007-01-19

Publications (2)

Publication Number Publication Date
WO2007103135A2 WO2007103135A2 (en) 2007-09-13
WO2007103135A3 true WO2007103135A3 (en) 2008-11-20

Family

ID=38475395

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/005291 WO2007103135A2 (en) 2006-03-02 2007-03-02 Active cell growth substrates and uses thereof

Country Status (1)

Country Link
WO (1) WO2007103135A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2558137B1 (en) 2010-04-12 2017-03-15 Spiber Technologies AB Methods and combination
CN102650077A (en) * 2011-02-24 2012-08-29 中国科学院合肥物质科学研究院 Chitosan-finishing iron nanowire, method for producing same and application thereof
US20140100138A1 (en) 2012-10-05 2014-04-10 The Regents Of The University Of California Mechanical stress response analysis of cells and tissues
IT201700087978A1 (en) 2017-07-31 2019-01-31 Univ Degli Studi Genova Three-dimensional hydrogel scaffold for cell cultures and its production method
EP4347785A2 (en) * 2021-05-28 2024-04-10 National University of Singapore Cell-culture platform and a magnetic material for such a platform

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033482A1 (en) * 2000-08-26 2004-02-19 Gerhard Artmann Device and method for the measurement of forces from living materials
US20040078090A1 (en) * 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US20050181973A1 (en) * 2003-06-25 2005-08-18 Massachusetts Institute Of Technology Self-assembling peptides incorporating modifications and methods of use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033482A1 (en) * 2000-08-26 2004-02-19 Gerhard Artmann Device and method for the measurement of forces from living materials
US20040078090A1 (en) * 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US20050181973A1 (en) * 2003-06-25 2005-08-18 Massachusetts Institute Of Technology Self-assembling peptides incorporating modifications and methods of use thereof

Also Published As

Publication number Publication date
WO2007103135A2 (en) 2007-09-13

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