WO2007085815A3 - Ligands that bind il-4 and/or il-13 - Google Patents

Ligands that bind il-4 and/or il-13 Download PDF

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Publication number
WO2007085815A3
WO2007085815A3 PCT/GB2007/000228 GB2007000228W WO2007085815A3 WO 2007085815 A3 WO2007085815 A3 WO 2007085815A3 GB 2007000228 W GB2007000228 W GB 2007000228W WO 2007085815 A3 WO2007085815 A3 WO 2007085815A3
Authority
WO
WIPO (PCT)
Prior art keywords
ligands
bind
interleukin
disclosed
methods
Prior art date
Application number
PCT/GB2007/000228
Other languages
French (fr)
Other versions
WO2007085815A2 (en
WO2007085815A8 (en
Inventor
Ian Tomlinson
Adrian Allart Stoop
Armin Sepp
Silva Inusha De
Caroline J Dimech
Malgorzata Pupecka
Wildt Rudolf M T De
Philip D Drew
Steve Holmes
Original Assignee
Domantis Ltd
Ian Tomlinson
Adrian Allart Stoop
Armin Sepp
Silva Inusha De
Caroline J Dimech
Malgorzata Pupecka
Wildt Rudolf M T De
Philip D Drew
Steve Holmes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US12/223,005 priority Critical patent/US20110159003A1/en
Priority to CA002636854A priority patent/CA2636854A1/en
Priority to JP2008551864A priority patent/JP2009523460A/en
Priority to EP07705003A priority patent/EP1976882A2/en
Priority to AU2007209202A priority patent/AU2007209202A1/en
Priority to BRPI0710572-0A priority patent/BRPI0710572A2/en
Priority to EA200801515A priority patent/EA200801515A1/en
Application filed by Domantis Ltd, Ian Tomlinson, Adrian Allart Stoop, Armin Sepp, Silva Inusha De, Caroline J Dimech, Malgorzata Pupecka, Wildt Rudolf M T De, Philip D Drew, Steve Holmes filed Critical Domantis Ltd
Publication of WO2007085815A2 publication Critical patent/WO2007085815A2/en
Publication of WO2007085815A3 publication Critical patent/WO2007085815A3/en
Priority to US12/152,903 priority patent/US20090060916A1/en
Priority to NO20082942A priority patent/NO20082942L/en
Priority to IL192572A priority patent/IL192572A0/en
Publication of WO2007085815A8 publication Critical patent/WO2007085815A8/en
Priority to US12/992,718 priority patent/US20120093830A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Disclosed are ligands that have binding specificity for interleukin-4 (IL-4), for interleukin-13 (IL-13), or for IL-4 and IL-13. Also disclosed are methods of using these ligands. In particular, the use of these ligands for treating allergic asthma is described.
PCT/GB2007/000228 2006-01-24 2007-01-24 Ligands that bind il-4 and/or il-13 WO2007085815A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
BRPI0710572-0A BRPI0710572A2 (en) 2006-01-24 2007-01-24 binder, use of binder, methods for treating an allergic, asthma and cancer disease, inhibiting a th2-type immune response, and administering anti-il-4 and anti-il-13 treatment, Pharmaceutical, Drug Dispensing Device, Isolated or Recombinant Nucleic Acid, Vector, Host Cell, Methods for Producing a Binder and Inhibiting Cell Proliferation
CA002636854A CA2636854A1 (en) 2006-01-24 2007-01-24 Ligands that bind il-4 and/or il-13
JP2008551864A JP2009523460A (en) 2006-01-24 2007-01-24 Ligand binding to IL-4 and / or IL-13
EP07705003A EP1976882A2 (en) 2006-01-24 2007-01-24 Ligands that bind il-4 and/or il-13
AU2007209202A AU2007209202A1 (en) 2006-01-24 2007-01-24 Ligands that bind IL-4 and/or IL-13
US12/223,005 US20110159003A1 (en) 2006-01-24 2007-01-24 Ligands That Bind Il-4 and/or Il-13
EA200801515A EA200801515A1 (en) 2006-01-24 2007-01-24 LIGANDS THAT BIND IL-4 AND / OR IL-13
US12/152,903 US20090060916A1 (en) 2006-01-24 2008-05-15 Ligands that bind IL-4 and/or IL-13
IL192572A IL192572A0 (en) 2006-01-24 2008-07-02 Ligands that bind il-4 and/or il-13
NO20082942A NO20082942L (en) 2006-01-24 2008-07-02 Ligands that bind IL-4 and / or IL-13
US12/992,718 US20120093830A1 (en) 2006-01-24 2009-05-13 Single domain antibodies that bind il-13

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76170806P 2006-01-24 2006-01-24
US60/761,708 2006-01-24

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/152,903 Continuation-In-Part US20090060916A1 (en) 2006-01-24 2008-05-15 Ligands that bind IL-4 and/or IL-13

Publications (3)

Publication Number Publication Date
WO2007085815A2 WO2007085815A2 (en) 2007-08-02
WO2007085815A3 true WO2007085815A3 (en) 2007-11-15
WO2007085815A8 WO2007085815A8 (en) 2008-07-31

Family

ID=38028503

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/000228 WO2007085815A2 (en) 2006-01-24 2007-01-24 Ligands that bind il-4 and/or il-13

Country Status (16)

Country Link
US (3) US20110159003A1 (en)
EP (1) EP1976882A2 (en)
JP (2) JP2009523460A (en)
KR (1) KR20080098382A (en)
CN (1) CN101578298A (en)
AU (1) AU2007209202A1 (en)
BR (1) BRPI0710572A2 (en)
CA (1) CA2636854A1 (en)
CR (1) CR10179A (en)
EA (1) EA200801515A1 (en)
IL (1) IL192572A0 (en)
MA (1) MA30175B1 (en)
NO (1) NO20082942L (en)
TW (2) TW200740843A (en)
WO (1) WO2007085815A2 (en)
ZA (1) ZA200806202B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8388965B2 (en) 2007-10-15 2013-03-05 Sanofi Antibodies that bind IL-4 and/or IL-13 and their uses

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007045477A2 (en) 2005-10-21 2007-04-26 Novartis Ag Human antibodies against il-13 and therapeutic uses
WO2009138413A1 (en) * 2008-05-15 2009-11-19 Domantis Limited Single domain antibodies that bind il-13
JP2009536527A (en) * 2006-05-09 2009-10-15 ジェネンテック・インコーポレーテッド Binding polypeptide with optimized scaffold
AU2007358569B2 (en) * 2007-09-07 2014-09-04 Ablynx N.V. Binding molecules with multiple binding sites, compositions comprising the same and uses thereof
EP2036980A1 (en) * 2007-09-14 2009-03-18 Gruber, Jens Down regulation of gene expression using virus-like particles charged with nucleic acid
AU2017201008B2 (en) * 2007-10-15 2018-12-13 Sanofi Antibodies that bind IL-4 and/or IL-13 and their uses
AU2008334605B2 (en) * 2007-12-13 2013-07-18 Glaxo Group Limited Polypeptides, antibody variable domains & antagonists
WO2009089295A2 (en) * 2008-01-07 2009-07-16 Government Of The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Anti-hiv domain antibodies and method of making and using same
CN112481367A (en) * 2008-03-31 2021-03-12 健泰科生物技术公司 Compositions and methods for treating and diagnosing asthma
US8217140B2 (en) 2008-04-17 2012-07-10 Ablynx N.V. Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same
WO2010035012A1 (en) * 2008-09-26 2010-04-01 Ucb Pharma S.A. Biological products
EP2356149A2 (en) * 2008-10-21 2011-08-17 Domantis Limited Ligands that have binding specificity for dc-sign
US8278419B2 (en) 2008-10-31 2012-10-02 Centocor Ortho Biotech Inc. Fibronectin type III domain based scaffold compositions, methods and uses
KR20110092328A (en) * 2008-11-26 2011-08-17 글락소 그룹 리미티드 Ligands that bind il-13
AU2009324354B2 (en) 2008-12-10 2016-04-14 Ablynx Nv Amino acid sequences directed against the Angiopoietin/Tie system and polypeptides comprising the same for the treatment of diseases and disorders related to angiogenesis
SG176203A1 (en) * 2009-05-28 2011-12-29 Glaxo Group Ltd Il-13 binding protein
ES2729422T3 (en) 2009-05-28 2019-11-04 Glaxo Group Ltd Antigen binding proteins
CA2768462A1 (en) * 2009-07-16 2011-01-20 Glaxo Group Ltd. Improved anti-serum albumin binding single variable domains
BR112012001977A2 (en) * 2009-07-29 2017-01-31 Glaxo Group Ltd immunoglobulin single variable domain, isolated polypeptide, binder, fusion protein, isolated nucleic acid, isolated nucleic acid molecule, vector, host cell, methods for making a polypeptide and for treating and / or preventing a condition, pharmaceutical composition, use of a single variable domain, and pulmonary dispensing device.
EP2531523A1 (en) 2010-02-05 2012-12-12 Ablynx N.V. Peptides capable of binding to serum albumin and compounds, constructs and polypeptides comprising the same
PL2533761T3 (en) * 2010-02-11 2019-09-30 Ablynx N.V. Methods and compositions for the preparation of aerosols
BR112012027863B1 (en) 2010-04-30 2023-03-07 Janssen Biotech, Inc POLYPEPTIDES, PROTEIN SCRABOWS, LIBRARIES AND METHODS OF CONSTRUCTION THEREOF, METHOD FOR GENERATING A PROTEIN SCRAPE BINDING TO A SPECIFIC TARGET WITH A PREDEFINED BINDING AFFINITY, ISOLATED NUCLEIC ACID MOLECULES, VECTORS, HOST CELLS, MEDICAL COMPOSITIONS, DEVICES AND MANUFACTURING ARTICLES
JP6062375B2 (en) 2011-01-06 2017-01-18 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ Ligand binding to TGF-beta receptor II
AR085911A1 (en) 2011-03-16 2013-11-06 Sanofi Sa SAFE THERAPEUTIC DOSE OF A SIMILAR PROTEIN TO AN ANTIBODY WITH VUAL REGION
US9527925B2 (en) 2011-04-01 2016-12-27 Boehringer Ingelheim International Gmbh Bispecific binding molecules binding to VEGF and ANG2
MY165090A (en) 2011-04-21 2018-02-28 Bristol Myers Squibb Co Antibody polypeptides that antagonize cd40
KR102142385B1 (en) 2011-09-27 2020-08-10 얀센 바이오테크 인코포레이티드 Fibronectin type iii repeat based protein scaffolds with alternative binding surfaces
US10481164B2 (en) * 2012-03-26 2019-11-19 Amgen Inc. Method for using light scattering in real time to directly monitor and control impurity removal in purification processes
PE20150643A1 (en) 2012-06-22 2015-05-29 Cytomx Therapeutics Inc ANTI-JAGGED 1 / JAGGED 2 CROSS-REACTIVE ANTIBODIES ACTIVABLE ANTI-JAGGED ANTIBODIES AND METHODS OF USE OF THEM
PT3470432T (en) 2012-08-21 2021-12-14 Regeneron Pharma Methods for treating or preventing asthma by administering an il-4r antagonist
CN113234142B (en) * 2012-08-22 2024-03-05 财团法人牧岩生命工学研究所 Screening and reconstruction method of hyperstable immunoglobulin variable domain and application thereof
CN106068125B (en) * 2013-12-17 2021-08-31 Mhs克尔创新有限责任公司 Compositions and methods for treating adipose tissue accumulation
US11066467B2 (en) 2013-12-17 2021-07-20 Mhs Care-Innovation Llc Compositions and methods for treating ischemic heart disease
KR102368450B1 (en) * 2014-02-21 2022-02-28 사노피 바이오테크놀로지 Methods for treating or preventing asthma by administering an il-4r antagonist
US10435475B2 (en) 2014-03-07 2019-10-08 Bristol-Myers Squibb Company Method of using antibody polypeptides that antagonize CD40 to treat IBD
MX2016013372A (en) 2014-04-11 2017-01-26 Novartis Ag Methods of selectively treating asthma using il-13 antagonists.
AU2015329936A1 (en) 2014-10-10 2017-04-20 Ablynx N.V. Methods of treating RSV infections
KR102364212B1 (en) 2014-10-10 2022-02-17 아블린쓰 엔.브이. Inhalation device for use in aerosol therapy of respiratory diseases
EP3218412A1 (en) 2014-11-14 2017-09-20 Sanofi Biotechnology Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist
WO2016097313A1 (en) 2014-12-19 2016-06-23 Ablynx N.V. Cysteine linked nanobody dimers
CN109311968A (en) 2016-05-02 2019-02-05 埃博灵克斯股份有限公司 Treat rsv infection
JP6293829B2 (en) * 2016-08-05 2018-03-14 モガム インスティチュート フォー バイオメディカル リサーチＭＯＧＡＭ Ｉｎｓｔｉｔｕｔｅ ｆｏｒ Ｂｉｏｍｅｄｉｃａｌ Ｒｅｓｅａｒｃｈ Stabilized immunoglobulin variable domain selection method and application of selected domains
WO2018099968A1 (en) 2016-11-29 2018-06-07 Ablynx N.V. Treatment of infection by respiratory syncytial virus (rsv)
BR112019012154A2 (en) 2016-12-14 2019-11-12 Janssen Biotech Inc cd8a-binding fibronectin type iii domains
EP3554535A4 (en) 2016-12-14 2020-10-21 Janssen Biotech, Inc. Pd-l1 binding fibronectin type iii domains
EP3554561B1 (en) 2016-12-14 2023-06-28 Janssen Biotech, Inc. Cd137 binding fibronectin type iii domains
CN111526920A (en) 2017-10-30 2020-08-11 赛诺菲生物技术公司 Methods of treating or preventing asthma by administering IL-4R antagonists
CN108855003B (en) * 2018-06-28 2021-01-05 南开大学 Immunoadsorbent for removing inflammatory factors in blood and preparation method thereof
CN111494625B (en) 2018-12-25 2022-06-21 江苏荃信生物医药股份有限公司 Pharmaceutical compositions for the treatment of IL-4 and/or IL-13 mediated signal transduction related disorders
WO2020176815A2 (en) * 2019-02-27 2020-09-03 Zhejiang Nanomab Technology Center Co. Ltd. Sequence-based high throughput method generating camelids antibodies to cover broad epitopes with high-resolution
EP4045061A4 (en) 2019-10-14 2024-04-17 Aro Biotherapeutics Company Cd71 binding fibronectin type iii domains
US11781138B2 (en) 2019-10-14 2023-10-10 Aro Biotherapeutics Company FN3 domain-siRNA conjugates and uses thereof
EP4144758A4 (en) 2020-04-22 2024-05-15 Mabwell Shanghai Bioscience Co Ltd Single variable domain antibody targeting human programmed death ligand 1 (pd-l1) and derivative thereof
IL297950A (en) * 2020-05-06 2023-01-01 Dragonfly Therapeutics Inc Antibodies targeting clec12a and use thereof
US20240117030A1 (en) * 2022-03-03 2024-04-11 Pfizer Inc. Multispecific antibodies and uses thereof
WO2024038112A1 (en) * 2022-08-17 2024-02-22 Institut National de la Santé et de la Recherche Médicale Improved anti-albumin nanobodies and their uses

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770403A (en) * 1992-02-19 1998-06-23 Schering Corporation Cloning and exprssion of humanized monoclonal antibodies against human interluekin-4
WO2004003019A2 (en) * 2002-06-28 2004-01-08 Domantis Limited Immunoglobin single variant antigen-binding domains and dual-specific constructs
WO2004058821A2 (en) * 2002-12-27 2004-07-15 Domantis Limited Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand
GB2403952A (en) * 2003-07-15 2005-01-19 Cambridge Antibody Tech IL-13 binding molecules
WO2005062967A2 (en) * 2003-12-23 2005-07-14 Tanox, Inc. Novel anti-il 13 antibodies and uses thereof
WO2005121177A2 (en) * 2004-06-09 2005-12-22 Wyeth Anti-il-13 antibodies, crystals of anti-il-13 antibodies and complexes comprising them
WO2006003407A2 (en) * 2004-07-01 2006-01-12 Glaxo Group Limited Chimeric and humanised monoclonal antibodies against inteleukin- 13

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869620A (en) * 1986-09-02 1999-02-09 Enzon, Inc. Multivalent antigen-binding proteins
US5637481A (en) * 1993-02-01 1997-06-10 Bristol-Myers Squibb Company Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
US5596072A (en) * 1992-08-21 1997-01-21 Schering Corporation Method of refolding human IL-13
US7585847B2 (en) * 2000-02-03 2009-09-08 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for the treatment of asthma and allergy
US7175988B2 (en) * 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
CA2554596A1 (en) * 2004-02-27 2005-09-15 Regeneron Pharmaceuticals, Inc. Il-4/il-13 specific polypetides and therapeutic uses thereof
WO2006023460A2 (en) * 2004-08-16 2006-03-02 Theravance, Inc. COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770403A (en) * 1992-02-19 1998-06-23 Schering Corporation Cloning and exprssion of humanized monoclonal antibodies against human interluekin-4
WO2004003019A2 (en) * 2002-06-28 2004-01-08 Domantis Limited Immunoglobin single variant antigen-binding domains and dual-specific constructs
WO2004058821A2 (en) * 2002-12-27 2004-07-15 Domantis Limited Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand
GB2403952A (en) * 2003-07-15 2005-01-19 Cambridge Antibody Tech IL-13 binding molecules
WO2005062967A2 (en) * 2003-12-23 2005-07-14 Tanox, Inc. Novel anti-il 13 antibodies and uses thereof
WO2005121177A2 (en) * 2004-06-09 2005-12-22 Wyeth Anti-il-13 antibodies, crystals of anti-il-13 antibodies and complexes comprising them
WO2006003407A2 (en) * 2004-07-01 2006-01-12 Glaxo Group Limited Chimeric and humanised monoclonal antibodies against inteleukin- 13

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DOMANTIS: "DOMANTIS' DUAL TARGETING DOMAIN ANTIBODIES SHOWN TO KILL MULTIPLE MYELOMA CELLS AND SPARE HEALTHY CELLS", 7 December 2005, XP002428485 *
DOMANTIS: "Fact sheet- Company overview", 27 August 2005, XP002434537 *
HART T K ET AL: "Preclinical efficacy and safety of pascolizumab (SB 240683): A humanized anti-interleukin-4 antibody with therapeutic potential in asthma", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 130, no. 1, October 2002 (2002-10-01), pages 93 - 100, XP002434532, ISSN: 0009-9104 *
HOLT L J ET AL: "Domain antibodies: proteins for therapy", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 21, no. 11, November 2003 (2003-11-01), pages 484 - 490, XP004467495, ISSN: 0167-7799 *
WAYBACKMACHINE: "History of Domantis web-site: Access: Aug 27 2005", 21 May 2007, XP002434538 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8388965B2 (en) 2007-10-15 2013-03-05 Sanofi Antibodies that bind IL-4 and/or IL-13 and their uses
KR101681909B1 (en) 2007-10-15 2016-12-05 사노피 Antibodies that bind IL-4 and/or IL-13 and their uses
KR101682373B1 (en) 2007-10-15 2016-12-06 사노피 Antibodies that bind IL-4 and/or IL-13 and their uses

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