WO2007079929A3 - Substituierte tricyclische piperidon-derivate - Google Patents

Substituierte tricyclische piperidon-derivate Download PDF

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Publication number
WO2007079929A3
WO2007079929A3 PCT/EP2006/012223 EP2006012223W WO2007079929A3 WO 2007079929 A3 WO2007079929 A3 WO 2007079929A3 EP 2006012223 W EP2006012223 W EP 2006012223W WO 2007079929 A3 WO2007079929 A3 WO 2007079929A3
Authority
WO
WIPO (PCT)
Prior art keywords
substituted tricyclic
piperidone derivatives
piperidone
derivatives
medicaments
Prior art date
Application number
PCT/EP2006/012223
Other languages
English (en)
French (fr)
Other versions
WO2007079929A2 (de
Inventor
Stefan Schunk
Stefan Oberboersch
Hagen-Heinrich Hennies
Martin Maier
Anton Khartulyari
Original Assignee
Gruenenthal Gmbh
Stefan Schunk
Stefan Oberboersch
Hagen-Heinrich Hennies
Martin Maier
Anton Khartulyari
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh, Stefan Schunk, Stefan Oberboersch, Hagen-Heinrich Hennies, Martin Maier, Anton Khartulyari filed Critical Gruenenthal Gmbh
Priority to EP06846988A priority Critical patent/EP1966138A2/de
Priority to JP2008546226A priority patent/JP2009520719A/ja
Publication of WO2007079929A2 publication Critical patent/WO2007079929A2/de
Publication of WO2007079929A3 publication Critical patent/WO2007079929A3/de
Priority to US12/143,614 priority patent/US20080312268A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Die vorliegende Erfindung betrifft substituierte tricyclische Piperidon-Derivate der Formel (I):Verfahren zu deren Herstellung, Arzneimittel enthaltend diese Verbindungen und die Verwendung von substituierten tricyclische Piperidon-Derivaten zur Herstellung von Arzneimitteln mit analgetische Wirkung.
PCT/EP2006/012223 2005-12-22 2006-12-19 Substituierte tricyclische piperidon-derivate WO2007079929A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP06846988A EP1966138A2 (de) 2005-12-22 2006-12-19 Substituierte tricyclische piperidon-derivate
JP2008546226A JP2009520719A (ja) 2005-12-22 2006-12-19 置換された三環状ピペリドン誘導体
US12/143,614 US20080312268A1 (en) 2005-12-22 2008-06-20 Substituted tricyclic piperidone compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005061426A DE102005061426A1 (de) 2005-12-22 2005-12-22 Substituierte tricyclische Piperidon-Derivate
DE102005061426.4 2005-12-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/143,614 Continuation US20080312268A1 (en) 2005-12-22 2008-06-20 Substituted tricyclic piperidone compounds

Publications (2)

Publication Number Publication Date
WO2007079929A2 WO2007079929A2 (de) 2007-07-19
WO2007079929A3 true WO2007079929A3 (de) 2007-09-27

Family

ID=38135534

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/012223 WO2007079929A2 (de) 2005-12-22 2006-12-19 Substituierte tricyclische piperidon-derivate

Country Status (5)

Country Link
US (1) US20080312268A1 (de)
EP (1) EP1966138A2 (de)
JP (1) JP2009520719A (de)
DE (1) DE102005061426A1 (de)
WO (1) WO2007079929A2 (de)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999055680A1 (en) * 1998-04-29 1999-11-04 Pfizer Products Inc. Aryl fused azapolycyclic compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3576812A (en) * 1968-07-02 1971-04-27 American Home Prod 1,5-methano-3-benzazocine derivatives
US3687937A (en) * 1970-06-23 1972-08-29 Us Of America The 1,5-methano-3-benzazocine derivatives
JPS5211149B2 (de) * 1972-06-01 1977-03-29

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999055680A1 (en) * 1998-04-29 1999-11-04 Pfizer Products Inc. Aryl fused azapolycyclic compounds
US6462035B1 (en) * 1998-04-29 2002-10-08 Pfizer Inc. Aryl fused azapolycyclic compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KHARTULYARI A.S. ET AL.: "Synthesis of Benzomorphan Analogues by Intramolecular Buchwald-Hartwig Cyclization", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, WILEY-VCH VERLAG, WEINHEIM, DE, vol. 2007, no. 2, 2007, pages 317 - 324, XP002440413, ISSN: 1434-193X *
SHIOTANI S ET AL: "9 HYDROXY-1 2 3 4 5 6-HEXAHYDRO-1 5-METHANO-3 BENZAZOCINE DERIVATIVES AS ANALGESICS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 20, no. 2, 1977, pages 310 - 312, XP002440414, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
US20080312268A1 (en) 2008-12-18
JP2009520719A (ja) 2009-05-28
WO2007079929A2 (de) 2007-07-19
DE102005061426A1 (de) 2007-07-05
EP1966138A2 (de) 2008-09-10

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