WO2007073139A1 - Couche diagnostique - Google Patents

Couche diagnostique Download PDF

Info

Publication number
WO2007073139A1
WO2007073139A1 PCT/MX2006/000141 MX2006000141W WO2007073139A1 WO 2007073139 A1 WO2007073139 A1 WO 2007073139A1 MX 2006000141 W MX2006000141 W MX 2006000141W WO 2007073139 A1 WO2007073139 A1 WO 2007073139A1
Authority
WO
WIPO (PCT)
Prior art keywords
reagent
detection
diagnostic
diaper
diaper according
Prior art date
Application number
PCT/MX2006/000141
Other languages
English (en)
Spanish (es)
Inventor
Nancy OLIVARES GONZÁLEZ
Original Assignee
Olivares Gonzalez Nancy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olivares Gonzalez Nancy filed Critical Olivares Gonzalez Nancy
Publication of WO2007073139A1 publication Critical patent/WO2007073139A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/42—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators with wetness indicator or alarm
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/525—Multi-layer analytical elements
    • G01N33/526—Multi-layer analytical elements the element being adapted for a specific analyte

Definitions

  • the present invention is related to disease diagnostic means by using reagent strips, and more particularly with a disposable diaper for infants or adults that includes a plurality of urine sensitive indicator reagents to detect levels of: glucose, ketone bodies, heavy metals such as lead, nitrites and specific gravity, fixed to the internal absorbent cover of the diaper; and a plurality of excrement-sensitive indicator reagents, to detect: fat, proteins and perform Clinitest test and viral tests
  • reagents that placed on a strip serve to guide diagnoses such as pregnancy tests as well as substances that are only found in urine in pathological situations.
  • Urine studies are used as diagnostic tools that provide a qualitative report of the presence of substances that can be detected in urine in pathological situations through chemical reactions that have color changes on contact with the rectors and detect reducing substances such as sugars, bilirubins, leukocytes, nitrites, urobilinogen, proteins, pH, blood, specific gravity, ketones, contaminants (lead, mercury, etc.) as well as medications, neurotransmitter derivatives, organic hormones etc. Said color changes that occur in each case are compared with control tables indicating the color corresponding to a positive result of the presence of a substance.
  • reagents are also offered in strips to detect substances such as ketone bodies, which serves to assess the effects of a diet in adults, so that self-monitoring can be done at home, but there are no reagents to date homemade to evaluate the urine of infants placed directly in a disposable reservoir and detect abnormal diseases or health conditions.
  • the diaper is also an excrement collector
  • reagents that identify reducing substances such as sugars in excrement were additionally included, it would be possible to diagnose sugar intolerance, indicating sugar absorption problems that indirectly confirm a diagnosis of rotavirus diarrhea, or absorption defect problems.
  • the Clinitest test is used, which is carried out in the office by means of a test strip using the same principle of the reaction of Benedict for urine and / or excrement. Adding said reagent to a diaper would allow monitoring at home of all evacuations of the user of this diaper and its clinical evolution.
  • a diaper with the reagents mentioned above would alert the user supervisor to indicate the need to go to a doctor or to evaluate in a laboratory the urine or excrement of the minor or of the older adult who uses disposable diaper, in addition said diaper would also be useful to the doctor to monitor possible diseases with the indication of the use of said diaper during the period of the disease with urine or pathological evacuations.
  • a diaper with reagents to detect substances such as metals would facilitate studies of environmental pollutants such as lead, mercury, etc. or other compounds that pollute the environment and are excreted in the urine, through tests such as that used by Masson's trichromatic dye to detect lead.
  • the abnormal substances to look for in the urine are leukocytes, these are cells that are not normally found in the urine unless the patient has an infection and their presence is detected when there are more than 5 to 15 cells. Said cells are detected with 0.5% w / w derived from acid thiazoamine ester, 0.4% diazonium salt, and 50% w / w buffer, and the results are not affected with the presence of other cells such as erythrocytes, bacteria or some protozoa (trichomonas) and even when the presence of bilirubins can increase the color of the reaction and the presence of glucose and proteins contribute to decrease the coloration, the result is positive when the reagent tone becomes purple or different shades of lilac.
  • the reagents for detecting nitrites give pink colors, the test of which is based on the principles of the Griess test and uses p-sulfanilic acid and 1.5% ethylenediamine. This test detects the nitrites that are characteristic of Gram negative bacteria and the pink coloration indicates the presence of said bacteria or an infection by bacteria in the urine.
  • the specific gravity test reflects the amount of ions in the urine, and is carried out by means of bromothymol blue whose greenish-yellow tones are indicative of an increase in ion concentration in
  • the urine which, together with the presence of glucose in the urine, can lead to a diagnosis suggestive of diabetes.
  • ketone bodies The detection of the presence of ketone bodies is based on the principle of the Legal test, which uses sodium nitroprusside that reacts with acetoacetic acid product of the organic metabolism of fat that is excreted in the urine in cases where fats be used by the body as the only source of energy. Positive results indicate states of prolonged fasting, catabolism or destruction of cells or diets that lack protein and carbohydrates. This detection of ketone bodies is also very useful in ketosic or ketogenic diets that are used as treatment in children who have seizures and these diets are the only way to control seizures.
  • the glucose detection is based on Benedic's tests that detect the presence of reducing substances such as sugars and produces a brown color with the reagents when sugars are present.
  • Test strips for home tests are available in self-services, especially for measuring ketones in patients on a dietary regimen or for measuring glucose in urine, etc., in tests for adults.
  • the reagents mentioned above for diagnosis of urine would be very useful because the same diaper would work as a home alarm that would warn when the patient presents a substance that is not found in common situations in the urine through a control guide, in which the appraiser will compare the colorations given by the different diaper reagents and assess whether there is an abnormally present substance, and will go to the doctor to perform a urine assessment or valuation order by a professional study to treat the disease in a timely manner.
  • a diaper that has these characteristics is described in US Patent No. 5,947,943 to Lee, which includes a moisture indicator material located on the inner side of the back cover which changes from appearance when exposed to moisture. Said material changes from a light color when it is dry to a dark color when it gets wet.
  • Jiménez Serrato claims a diaper with incorporated indicators sensitive to urine to detect pH level, nitrates, bilirubin, acetone, proteins, blood and urobilinogen.
  • the Jiménez Serrato patent does not describe or suggest to include indicators for the diagnosis of excrement, nor that the indicators incorporated into the diaper are sensitive to glucose, ketone bodies, sugars, fat, heavy metals such as lead, specific gravity, Clinitest test and viral tests.
  • the applicant developed a disposable diaper that includes indicators sensitive to urine and excrement to detect glucose, ketone bodies, fat, proteins, heavy metals such as lead, specific gravity and to perform the Clinitest test and viral tests for detect among other viruses rotavirus, adenovirus and echovirus.
  • the diaper developed by the applicant serves as a control to monitor the urine and feces of the patient in search of substances that are not found in common situations in the urine and feces by means of said indicators, by means of which the appraiser will compare the colorations that give the different diaper indicator reagents and would assess if there is an abnormally present substance.
  • the disposable diaper comprises: an internal absorbent cover; an external water-repellent cover, an absorbent core positioned between the internal and external cover; a lateral fin extending on each side of the absorbent core; a side barrier arranged adjacent to each side end of the article, which may be incorporated directly or indirectly.
  • the invention comprises: a plurality of urine sensitive indicator reagents for detecting: glucose, ketone bodies, heavy metals such as lead, nitrites and specific gravity, fixed to the diaper absorbent inner shell; and a plurality of indicator reagents sensitive to excrement, to detect: fat, proteins and perform Clinitest test and viral tests to detect, among other viruses, the rotavirus, adenovirus and echovirus, fixed to the diaper absorbent inner shell.
  • the invention comprises: Urine sensitive strip type indicators attached to the diaper absorbent inner shell, each indicator including: a reagent for glucose detection comprising Benedic tests; a reagent for the detection of ketone bodies comprising sodium nitroprusside; a reagent for the detection of heavy metals such as lead comprising Masson's trichromatic; a reagent for the detection of nitrites comprising p-sulfanilic acid and 1.5% ethylenediamine; and a reagent for the detection of specific gravity comprising bromothymol blue; strip type indicators sensitive to excrement, fixed to the internal absorbent diaper cover, each indicator comprising: a reagent for performing the Clinitest test; a reagent for the detection of fat comprising Sudan black; a reagent for the detection of proteins comprising Biuret reagent; a viral test reagent comprising the Rotatest test, which contains rotavirus antibodies;
  • the strips can be adhered to the inner diaper cover by means of an adherent substance in a suitable position so that they can receive the urine and the excrement.
  • any other suitable material can be impregnated with the reagents corresponding to each indicator or impregnated said reagents directly in the fiber of the inner diaper cover.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Absorbent Articles And Supports Therefor (AREA)

Abstract

L'invention concerne une couche diagnostique jetable comprenant une pluralité de réactifs indicateurs sensibles à l'urine, permettant de détecter les niveaux de glucose, de corps cétoniques, de métaux lourds comme le plomb, de nitrites, et leur gravité spécifique, fixés à la partie interne absorbante de la couche, et une pluralité de réactifs indicateurs sensibles aux excréments, permettant de détecter la graisse et les protéines, et d'effectuer un Clinitest et des analyses virales. Ladite couche permet de surveiller de manière contrôlée l'urine et les selles du patient dans la recherche de substances ne se trouvant pas communément dans l'urine et les selles à l'aide desdits indicateurs, au moyen desquels le technicien d'analyse compare les colorations que donnent les différents réactifs des indicateurs de la couche et détermine l'existence anormale d'une substance.
PCT/MX2006/000141 2005-12-21 2006-12-08 Couche diagnostique WO2007073139A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MXNL05000103A MXNL05000103A (es) 2005-12-21 2005-12-21 Panal diagnostico.
MXNL/A/2005/000103 2005-12-21

Publications (1)

Publication Number Publication Date
WO2007073139A1 true WO2007073139A1 (fr) 2007-06-28

Family

ID=38188844

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MX2006/000141 WO2007073139A1 (fr) 2005-12-21 2006-12-08 Couche diagnostique

Country Status (2)

Country Link
MX (1) MXNL05000103A (fr)
WO (1) WO2007073139A1 (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8816149B2 (en) 2011-10-28 2014-08-26 Kimberly-Clark Worldwide, Inc. System for detection and monitoring of body exudates using a gas emitting substance for use in interactive toilet training
US8933292B2 (en) 2011-10-28 2015-01-13 Kimberly-Clark Worldwide, Inc. Absorbent article with sensor array for body exudate detection
US9119748B2 (en) 2011-10-28 2015-09-01 Kimberly-Clark Worldwide, Inc. Electronic discriminating device for body exudate detection
US9131893B2 (en) 2012-10-26 2015-09-15 Pixie Scientific, Llc Health diagnostic systems and methods
CN109655448A (zh) * 2019-01-07 2019-04-19 安徽铜冠有色金属（池州）有限责任公司 电感耦合等离子体原子发射光谱法测尿铅的方法
US10383564B2 (en) 2015-05-22 2019-08-20 Pixie Scientific, Llc Indicator panels for incontinence products
WO2020242405A1 (fr) * 2019-05-29 2020-12-03 İstanbul Üni̇versi̇tesi̇ Rektörlüğü Produits d'hygiène absorbants à usage unique pour la détection de cétone dans l'urine
US11234680B2 (en) 2016-04-01 2022-02-01 Palma Group S.A. Diaper for collecting biological samples
US11662304B2 (en) 2021-09-17 2023-05-30 Johnson & Johnson Consumer Inc. System and method for in situ measuring and collecting samples of analyte concentration in bodily fluids
WO2023180691A1 (fr) 2022-03-23 2023-09-28 iDE8 Limited Appareil et procédés de biocapteur à base de polymère superabsorbant
US11921050B2 (en) 2020-03-23 2024-03-05 Johnson & Johnson Consumer Inc. Predictive method using colorimetric analysis of bodily fluids

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2022423A (en) * 1978-07-07 1979-12-19 Super Iride Spa Improvements in and relating to sanitary clothing
WO2000015169A1 (fr) * 1998-09-16 2000-03-23 Paula Jimenez Cerrato Couche-culotte dotee d'indicateurs sensibles a l'etat de l'urine l'impregnant et visibles de l'exterieur
WO2001013109A2 (fr) * 1999-08-12 2001-02-22 Gael Michael R Dispositif comprenant des reactifs utilise pour detecter des etats pathologiques
US6479727B1 (en) * 1999-06-29 2002-11-12 Donald C. Roe Diagnostic panel

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2022423A (en) * 1978-07-07 1979-12-19 Super Iride Spa Improvements in and relating to sanitary clothing
WO2000015169A1 (fr) * 1998-09-16 2000-03-23 Paula Jimenez Cerrato Couche-culotte dotee d'indicateurs sensibles a l'etat de l'urine l'impregnant et visibles de l'exterieur
US6479727B1 (en) * 1999-06-29 2002-11-12 Donald C. Roe Diagnostic panel
WO2001013109A2 (fr) * 1999-08-12 2001-02-22 Gael Michael R Dispositif comprenant des reactifs utilise pour detecter des etats pathologiques

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8816149B2 (en) 2011-10-28 2014-08-26 Kimberly-Clark Worldwide, Inc. System for detection and monitoring of body exudates using a gas emitting substance for use in interactive toilet training
US8933292B2 (en) 2011-10-28 2015-01-13 Kimberly-Clark Worldwide, Inc. Absorbent article with sensor array for body exudate detection
US9119748B2 (en) 2011-10-28 2015-09-01 Kimberly-Clark Worldwide, Inc. Electronic discriminating device for body exudate detection
US9131893B2 (en) 2012-10-26 2015-09-15 Pixie Scientific, Llc Health diagnostic systems and methods
US10251602B2 (en) 2012-10-26 2019-04-09 Pixie Scientific, Llc Health diagnostic systems and methods
US10383564B2 (en) 2015-05-22 2019-08-20 Pixie Scientific, Llc Indicator panels for incontinence products
US11234680B2 (en) 2016-04-01 2022-02-01 Palma Group S.A. Diaper for collecting biological samples
CN109655448A (zh) * 2019-01-07 2019-04-19 安徽铜冠有色金属（池州）有限责任公司 电感耦合等离子体原子发射光谱法测尿铅的方法
WO2020242405A1 (fr) * 2019-05-29 2020-12-03 İstanbul Üni̇versi̇tesi̇ Rektörlüğü Produits d'hygiène absorbants à usage unique pour la détection de cétone dans l'urine
US11921050B2 (en) 2020-03-23 2024-03-05 Johnson & Johnson Consumer Inc. Predictive method using colorimetric analysis of bodily fluids
US11662304B2 (en) 2021-09-17 2023-05-30 Johnson & Johnson Consumer Inc. System and method for in situ measuring and collecting samples of analyte concentration in bodily fluids
WO2023180691A1 (fr) 2022-03-23 2023-09-28 iDE8 Limited Appareil et procédés de biocapteur à base de polymère superabsorbant

Also Published As

Publication number Publication date
MXNL05000103A (es) 2007-06-20

Similar Documents

Publication Publication Date Title
WO2007073139A1 (fr) Couche diagnostique
JP5260543B2 (ja) ラテラルフローアッセイデバイス及び当該デバイスを含む吸収性物品
ES2329481T3 (es) Dispositivo y metodo de examen de sangre fecal oculta.
JP6487071B2 (ja) 一体化された集尿器と副作用の軽減を可能にするセンサとを有する光線療法装置
US20080050451A1 (en) Methods for assessing dehydration and shock, assays and kits for the methods
WO2000015169A1 (fr) Couche-culotte dotee d'indicateurs sensibles a l'etat de l'urine l'impregnant et visibles de l'exterieur
BRPI0809885B1 (pt) artigo absorvente, e, método para detectar presença de um analito na urina
WO2003005946A1 (fr) Article sanitaire pour analyse de l'etat d'un organisme et methode correspondante
KR200390501Y1 (ko) 질병진단기능을 가진 기저귀
US10660301B1 (en) Health monitoring cat litter
KR20190057825A (ko) 부착형 소변검사 스티커
WO2019089768A1 (fr) Dispositif à faible ressource et système de mesure des taux de bilirubine
Sheets et al. Urinalysis
JP2017032338A (ja) 尿中ケトン体検出紙オムツ
CN109765224A (zh) 一种胶带基的尿液传感器
CN215875246U (zh) 一种粪隐血即时检测纸尿裤
KR20230086503A (ko) 반려동물용 소변 검사 기저귀
JP6635345B2 (ja) 尿中のバイオマーカーを検出するための方法及び該方法に用いるためのキット
RU2338191C1 (ru) Способ определения степени тяжести эндогенной интоксикации у новорожденных детей с гипербилирубинэмией
KR20070024882A (ko) 건강진단용 팬티
WO2017168388A1 (fr) Couche pour prélèvement d'échantillons biologiques
US20230054322A1 (en) Urine indication pad with inbuilt diagnostics for training and indication of potential disease
JP6778035B2 (ja) 体液中成分検出用試験片
JP4999727B2 (ja) 簡易尿採集器、およびそれを用いた２４時間尿中塩類簡易測定方法
Sinha et al. Biosensors for Point‐of‐Care Applications: Replacing Pathology Labs by Bedside Devices

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06843906

Country of ref document: EP

Kind code of ref document: A1