WO2007065037A3 - Antibodies against mmp-13 (collagenase-3) and uses thereof - Google Patents

Antibodies against mmp-13 (collagenase-3) and uses thereof Download PDF

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Publication number
WO2007065037A3
WO2007065037A3 PCT/US2006/046625 US2006046625W WO2007065037A3 WO 2007065037 A3 WO2007065037 A3 WO 2007065037A3 US 2006046625 W US2006046625 W US 2006046625W WO 2007065037 A3 WO2007065037 A3 WO 2007065037A3
Authority
WO
WIPO (PCT)
Prior art keywords
light chain
collagenase
immunoglobulin molecules
sequences
antibodies against
Prior art date
Application number
PCT/US2006/046625
Other languages
French (fr)
Other versions
WO2007065037A2 (en
Inventor
Ian Foltz
Peter Mezes
Joseph Eichen
Original Assignee
Curagen Corp
Amgen Fremont Inc
Ian Foltz
Peter Mezes
Joseph Eichen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curagen Corp, Amgen Fremont Inc, Ian Foltz, Peter Mezes, Joseph Eichen filed Critical Curagen Corp
Publication of WO2007065037A2 publication Critical patent/WO2007065037A2/en
Publication of WO2007065037A3 publication Critical patent/WO2007065037A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Antibodies directed to the antigen MMP-13 and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen MMP-13. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR' s), specifically from FRl through FR4 or CDRl through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.
PCT/US2006/046625 2005-12-02 2006-12-04 Antibodies against mmp-13 (collagenase-3) and uses thereof WO2007065037A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74193305P 2005-12-02 2005-12-02
US60/741,933 2005-12-02

Publications (2)

Publication Number Publication Date
WO2007065037A2 WO2007065037A2 (en) 2007-06-07
WO2007065037A3 true WO2007065037A3 (en) 2008-10-23

Family

ID=38092911

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/046625 WO2007065037A2 (en) 2005-12-02 2006-12-04 Antibodies against mmp-13 (collagenase-3) and uses thereof

Country Status (1)

Country Link
WO (1) WO2007065037A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2186894A4 (en) * 2007-07-10 2010-10-20 Shionogi & Co Monoclonal antibody having neutralizing activity against mmp13
CA2892973A1 (en) * 2012-11-28 2014-06-05 Cnj Holdings, Inc. Antibodies against clostridium difficile
WO2015057906A1 (en) * 2013-10-16 2015-04-23 Janssen Biotech, Inc. Cd200 receptor 1 agonists
CN111733140B (en) * 2020-04-04 2022-07-01 华中农业大学 Hybridoma cell strain resisting canine matrix metalloproteinase, preparation method thereof, monoclonal antibody and application thereof
WO2021217024A1 (en) * 2020-04-24 2021-10-28 Millennium Pharmaceuticals, Inc. Anti-cd19 antibodies and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020173508A1 (en) * 1997-03-04 2002-11-21 Freskos John N. Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds
WO2003035048A2 (en) * 2001-10-26 2003-05-01 Novartis Ag Methods for the treatment of osteoarthritis and compositions thereof
US20030139332A1 (en) * 2001-07-09 2003-07-24 The Regents Of The University Of California Use of matrix metalloproteinase inhibitors to mitigate nerve damage
US20040259802A1 (en) * 2003-06-20 2004-12-23 Shu-Ping Yang Anti-chrondrosarcoma compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020173508A1 (en) * 1997-03-04 2002-11-21 Freskos John N. Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds
US20030139332A1 (en) * 2001-07-09 2003-07-24 The Regents Of The University Of California Use of matrix metalloproteinase inhibitors to mitigate nerve damage
WO2003035048A2 (en) * 2001-10-26 2003-05-01 Novartis Ag Methods for the treatment of osteoarthritis and compositions thereof
US20040259802A1 (en) * 2003-06-20 2004-12-23 Shu-Ping Yang Anti-chrondrosarcoma compounds

Also Published As

Publication number Publication date
WO2007065037A2 (en) 2007-06-07

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