WO2007054436A3 - Thiazolo [4 , 5-c] pyridine derivatives as mglu5 receptor antagonists - Google Patents
Thiazolo [4 , 5-c] pyridine derivatives as mglu5 receptor antagonists Download PDFInfo
- Publication number
- WO2007054436A3 WO2007054436A3 PCT/EP2006/067794 EP2006067794W WO2007054436A3 WO 2007054436 A3 WO2007054436 A3 WO 2007054436A3 EP 2006067794 W EP2006067794 W EP 2006067794W WO 2007054436 A3 WO2007054436 A3 WO 2007054436A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- receptor antagonists
- thiazolo
- pyridine derivatives
- mglu5 receptor
- mglu5
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2006311084A AU2006311084A1 (en) | 2005-11-08 | 2006-10-26 | Thiazolo [4 , 5-c] pyridine derivatives as mGlu5 receptor antagonists |
CN2006800386693A CN101291939B (en) | 2005-11-08 | 2006-10-26 | Thiazolo[4,5-C]pyridine derivatives as mGluR5 receptor antagonists |
AT06807563T ATE553108T1 (en) | 2005-11-08 | 2006-10-26 | THIAZOLOA4,5-CUPYRIDINE DERIVATIVE AS ANTAGONISTS OF THE MGLU5 RECEPTOR |
ES06807563T ES2382162T3 (en) | 2005-11-08 | 2006-10-26 | Thiazolo [4,5-c] pyridine derivatives as MGLU5 receptor antagonists |
BRPI0618636-0A BRPI0618636A2 (en) | 2005-11-08 | 2006-10-26 | thiazolo [4,5-c] pyridine derivatives |
CA002628936A CA2628936A1 (en) | 2005-11-08 | 2006-10-26 | Thiazolo [4 , 5-c] pyridine derivatives as mglu5 receptor antagonists |
EP06807563A EP1948667B1 (en) | 2005-11-08 | 2006-10-26 | Thiazolo[4,5-c]pyridine derivatives as mglu5 receptor antagonists |
JP2008539390A JP5015166B2 (en) | 2005-11-08 | 2006-10-26 | Thiazolo [4,5-c] pyridine derivatives as mGlu5 receptor antagonists |
IL190989A IL190989A0 (en) | 2005-11-08 | 2008-04-17 | Thiazolo [4,5-c]pyridine derivatives |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05110461 | 2005-11-08 | ||
EP05110461.0 | 2005-11-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007054436A2 WO2007054436A2 (en) | 2007-05-18 |
WO2007054436A3 true WO2007054436A3 (en) | 2007-06-28 |
Family
ID=37897285
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2006/067794 WO2007054436A2 (en) | 2005-11-08 | 2006-10-26 | Thiazolo [4 , 5-c] pyridine derivatives as mglu5 receptor antagonists |
Country Status (16)
Country | Link |
---|---|
US (1) | US7659401B2 (en) |
EP (1) | EP1948667B1 (en) |
JP (1) | JP5015166B2 (en) |
KR (1) | KR101020431B1 (en) |
CN (1) | CN101291939B (en) |
AR (1) | AR058179A1 (en) |
AT (1) | ATE553108T1 (en) |
AU (1) | AU2006311084A1 (en) |
BR (1) | BRPI0618636A2 (en) |
CA (1) | CA2628936A1 (en) |
ES (1) | ES2382162T3 (en) |
IL (1) | IL190989A0 (en) |
RU (1) | RU2425834C2 (en) |
TW (1) | TWI323261B (en) |
WO (1) | WO2007054436A2 (en) |
ZA (1) | ZA200803821B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2696016A1 (en) | 2007-07-13 | 2009-01-22 | Addex Pharma S.A. | Novel heteroaromatic derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors |
GB0800411D0 (en) * | 2008-01-10 | 2008-02-20 | Glaxo Group Ltd | Novel compounds |
CN102666552B (en) * | 2009-12-18 | 2014-11-26 | 詹森药业有限公司 | Bicyclic thiazoles as allosteric modulators of MGLUR5 receptors |
CA2782947A1 (en) * | 2009-12-18 | 2011-06-23 | Janssen Pharmaceutica Nv | Bicyclic thiazoles as allosteric modulators of mglur5 receptors |
WO2017147312A1 (en) | 2016-02-23 | 2017-08-31 | Indiana University Research & Technology Corporation | Combination therapies for treatment of spinal muscular atrophy |
KR102224677B1 (en) | 2018-08-23 | 2021-03-08 | 가천대학교 산학협력단 | Thiazolopiperazine derivatives and composition for preventing or treating autoimmune diseases comprising the same |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004067002A2 (en) * | 2003-01-30 | 2004-08-12 | Recordati Ireland Limited | SELECTIVE mGlu5 ANTAGONISTS FOR TREATMENT OF NEUROMUSCULAR DYSFUNCTION OF THE LOWER URINARY TRACT |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0321115B1 (en) | 1987-12-14 | 1991-08-14 | Sawai Pharmaceutical Co., Ltd. | Carboxamide derivatives having tetrazole and thiazole rings and their use |
JP2695037B2 (en) * | 1990-11-07 | 1997-12-24 | 富士通株式会社 | Error pulse stretching circuit |
US6107300A (en) * | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
WO1998005651A1 (en) | 1996-08-01 | 1998-02-12 | Warner-Lambert Company | Novel glutamate receptor antagonists: fused cycloalkyl quinoxalinediones |
US6658606B1 (en) * | 1997-10-29 | 2003-12-02 | Continental Teves Ag & Co. Ohg | Method and device for checking an error control procedure of a circuit |
US6660753B2 (en) | 1999-08-19 | 2003-12-09 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
MXPA02001764A (en) | 1999-08-19 | 2004-03-19 | Nps Pharma Inc | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists. |
KR100825182B1 (en) | 2000-11-30 | 2008-04-24 | 캐논 가부시끼가이샤 | Luminescent Element and Display |
RU2319701C2 (en) | 2001-02-21 | 2008-03-20 | Астразенека Аб | HETEROPOLYCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION POSSESSING ANTAGONISTIC ACTIVITY WITH RESPECT TO METABOTROPIC GLUTAMATE RECEPTORS mGluR OF GROUP I |
US6890931B2 (en) | 2001-04-02 | 2005-05-10 | Brown University | Methods of treating disorders with group I mGluR antagonists |
US6529046B1 (en) * | 2001-12-12 | 2003-03-04 | Etron Technology, Inc. | Minimum pulse width detection and regeneration circuit |
AU2003270701B2 (en) * | 2002-10-31 | 2009-11-12 | Amgen Inc. | Antiinflammation agents |
EP1781647A2 (en) | 2004-07-22 | 2007-05-09 | Astex Therapeutics Limited | Thiazole and isothiazole derivatives as protein kinase inhibitors |
JP2008534664A (en) * | 2005-04-06 | 2008-08-28 | アストラゼネカ アクチボラグ | Substituted heterocycles and their use as CHK1, PDK1 and PAK inhibitors |
-
2006
- 2006-10-26 BR BRPI0618636-0A patent/BRPI0618636A2/en not_active IP Right Cessation
- 2006-10-26 EP EP06807563A patent/EP1948667B1/en not_active Not-in-force
- 2006-10-26 JP JP2008539390A patent/JP5015166B2/en not_active Expired - Fee Related
- 2006-10-26 RU RU2008115034/04A patent/RU2425834C2/en not_active IP Right Cessation
- 2006-10-26 WO PCT/EP2006/067794 patent/WO2007054436A2/en active Application Filing
- 2006-10-26 ES ES06807563T patent/ES2382162T3/en active Active
- 2006-10-26 AT AT06807563T patent/ATE553108T1/en active
- 2006-10-26 AU AU2006311084A patent/AU2006311084A1/en not_active Abandoned
- 2006-10-26 KR KR1020087013474A patent/KR101020431B1/en not_active IP Right Cessation
- 2006-10-26 CN CN2006800386693A patent/CN101291939B/en not_active Expired - Fee Related
- 2006-10-26 CA CA002628936A patent/CA2628936A1/en not_active Abandoned
- 2006-10-31 US US11/590,087 patent/US7659401B2/en not_active Expired - Fee Related
- 2006-11-06 AR ARP060104855A patent/AR058179A1/en not_active Application Discontinuation
- 2006-11-06 TW TW095140997A patent/TWI323261B/en not_active IP Right Cessation
-
2008
- 2008-04-17 IL IL190989A patent/IL190989A0/en unknown
- 2008-05-05 ZA ZA200803821A patent/ZA200803821B/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004067002A2 (en) * | 2003-01-30 | 2004-08-12 | Recordati Ireland Limited | SELECTIVE mGlu5 ANTAGONISTS FOR TREATMENT OF NEUROMUSCULAR DYSFUNCTION OF THE LOWER URINARY TRACT |
Non-Patent Citations (1)
Title |
---|
MUTEL V: "Therapeutic potential of non-competitive, substype selective, metabotropic glutamate receptor ligands", EXPERT OPINION ON THERAPEUTIC PATENTS, ASHLEY PUBLICATIONS, GB, vol. 12, 2002, pages 1845 - 1852, XP002394958, ISSN: 1354-3776 * |
Also Published As
Publication number | Publication date |
---|---|
TWI323261B (en) | 2010-04-11 |
KR20080069229A (en) | 2008-07-25 |
WO2007054436A2 (en) | 2007-05-18 |
US7659401B2 (en) | 2010-02-09 |
EP1948667A2 (en) | 2008-07-30 |
US20070105891A1 (en) | 2007-05-10 |
ZA200803821B (en) | 2009-03-25 |
CN101291939B (en) | 2013-02-13 |
AU2006311084A1 (en) | 2007-05-18 |
JP5015166B2 (en) | 2012-08-29 |
AR058179A1 (en) | 2008-01-23 |
ATE553108T1 (en) | 2012-04-15 |
CA2628936A1 (en) | 2007-05-18 |
CN101291939A (en) | 2008-10-22 |
RU2008115034A (en) | 2009-12-20 |
RU2425834C2 (en) | 2011-08-10 |
IL190989A0 (en) | 2008-12-29 |
KR101020431B1 (en) | 2011-03-08 |
TW200736264A (en) | 2007-10-01 |
BRPI0618636A2 (en) | 2011-09-06 |
JP2009514923A (en) | 2009-04-09 |
ES2382162T3 (en) | 2012-06-05 |
EP1948667B1 (en) | 2012-04-11 |
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