WO2007048102A3 - Angio-inhibitory peptides derived from human timp-2 - Google Patents
Angio-inhibitory peptides derived from human timp-2 Download PDFInfo
- Publication number
- WO2007048102A3 WO2007048102A3 PCT/US2006/060061 US2006060061W WO2007048102A3 WO 2007048102 A3 WO2007048102 A3 WO 2007048102A3 US 2006060061 W US2006060061 W US 2006060061W WO 2007048102 A3 WO2007048102 A3 WO 2007048102A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- angio
- peptides derived
- inhibitory peptides
- human timp
- proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention provides proteins and polypeptides with anti-angiogenic activity. The proteins may be prepared by recombinant or other synthetic means and may be formulated in compositions as needed to facilitate their use. The invention further provides methods of inhibiting or reducing angiogenesis as well as the treatment of angiogenesis mediated diseases.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72814605P | 2005-10-18 | 2005-10-18 | |
US60/728,146 | 2005-10-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007048102A2 WO2007048102A2 (en) | 2007-04-26 |
WO2007048102A3 true WO2007048102A3 (en) | 2007-12-27 |
Family
ID=37963410
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/060061 WO2007048102A2 (en) | 2005-10-18 | 2006-10-18 | Angio-inhibitory peptides derived from human timp-2 |
PCT/US2006/060059 WO2007048100A2 (en) | 2005-10-18 | 2006-10-18 | Angio-inhibitory peptides derived from human timp-2 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/060059 WO2007048100A2 (en) | 2005-10-18 | 2006-10-18 | Angio-inhibitory peptides derived from human timp-2 |
Country Status (1)
Country | Link |
---|---|
WO (2) | WO2007048102A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2920521A1 (en) * | 2013-08-07 | 2015-02-12 | Astute Medical, Inc. | Assays for timp2 having improved performance in biological samples |
WO2018187453A1 (en) | 2017-04-05 | 2018-10-11 | Astute Medical, Inc. | Assays for timp2 having improved performance in biological samples |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990011287A1 (en) * | 1989-03-21 | 1990-10-04 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Matrix metalloproteinase inhibitor peptides |
WO2003057884A1 (en) * | 2002-01-08 | 2003-07-17 | Leadbio Inc. | Human serum albumin-timp2 fusion protein, a polynucleotide encoding the same and a method of producing the human serum albumin-timp2 fusion protein |
WO2004060275A2 (en) * | 2002-12-19 | 2004-07-22 | Kimberly-Clark Worldwide, Inc. | Wound care compositions |
-
2006
- 2006-10-18 WO PCT/US2006/060061 patent/WO2007048102A2/en active Application Filing
- 2006-10-18 WO PCT/US2006/060059 patent/WO2007048100A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990011287A1 (en) * | 1989-03-21 | 1990-10-04 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Matrix metalloproteinase inhibitor peptides |
WO2003057884A1 (en) * | 2002-01-08 | 2003-07-17 | Leadbio Inc. | Human serum albumin-timp2 fusion protein, a polynucleotide encoding the same and a method of producing the human serum albumin-timp2 fusion protein |
WO2004060275A2 (en) * | 2002-12-19 | 2004-07-22 | Kimberly-Clark Worldwide, Inc. | Wound care compositions |
Non-Patent Citations (2)
Title |
---|
FERNANDEZ CECILIA A ET AL: "Structural and functional uncoupling of the enzymatic and angiogenic inhibitory activities of tissue inhibitor of metalloproteinase-2 (TIMP-2). Loop 6 is a novel angiogenesis inhibitor.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 42, 17 October 2003 (2003-10-17), pages 40989 - 40995, XP002435349, ISSN: 0021-9258 * |
SEO D-W ET AL: "TIMP-2 mediated inhibition of angiogenesis: An MMP-independent mechanism", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 114, no. 2, 25 July 2003 (2003-07-25), pages 171 - 180, XP002313229, ISSN: 0092-8674 * |
Also Published As
Publication number | Publication date |
---|---|
WO2007048100A2 (en) | 2007-04-26 |
WO2007048100A3 (en) | 2008-02-07 |
WO2007048102A2 (en) | 2007-04-26 |
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