WO2007042289A3 - Nanobodies™ and polypeptides against egfr and igf-ir - Google Patents

Nanobodies™ and polypeptides against egfr and igf-ir Download PDF

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Publication number
WO2007042289A3
WO2007042289A3 PCT/EP2006/009840 EP2006009840W WO2007042289A3 WO 2007042289 A3 WO2007042289 A3 WO 2007042289A3 EP 2006009840 W EP2006009840 W EP 2006009840W WO 2007042289 A3 WO2007042289 A3 WO 2007042289A3
Authority
WO
WIPO (PCT)
Prior art keywords
nanobodies
polypeptides
igf
nucleic acids
host cells
Prior art date
Application number
PCT/EP2006/009840
Other languages
French (fr)
Other versions
WO2007042289A2 (en
Inventor
Toon Laeremans
Haard Hans De
Hendricus Renerus J Hoogenboom
Original Assignee
Ablynx Nv
Toon Laeremans
Haard Hans De
Hendricus Renerus J Hoogenboom
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ablynx Nv, Toon Laeremans, Haard Hans De, Hendricus Renerus J Hoogenboom filed Critical Ablynx Nv
Priority to EP06792421A priority Critical patent/EP1934259A2/en
Priority to CA002624781A priority patent/CA2624781A1/en
Priority to US12/083,406 priority patent/US20090252681A1/en
Priority to JP2008534933A priority patent/JP2009511032A/en
Priority to AU2006301426A priority patent/AU2006301426A1/en
Publication of WO2007042289A2 publication Critical patent/WO2007042289A2/en
Publication of WO2007042289A3 publication Critical patent/WO2007042289A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®

Abstract

The invention relates to polypeptides and Nanobodies against Epidermal Growth Factor Receptor (EGFR) and/or Insulin Growth Factor-I Receptor (IGF-IR). The invention also relates to nucleic acids encoding such Nanobodies and polypeptides; to methods for preparing such Nanobodies and polypeptides; to host cells expressing or capable of expressing such Nanobodies or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such Nanobodies, polypeptides, nucleic acids and/or host cells; and to uses of such Nanobodies, polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
PCT/EP2006/009840 2005-10-11 2006-10-11 Nanobodies™ and polypeptides against egfr and igf-ir WO2007042289A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP06792421A EP1934259A2 (en) 2005-10-11 2006-10-11 Nanobodies and polypeptides against egfr and igf-ir
CA002624781A CA2624781A1 (en) 2005-10-11 2006-10-11 Nanobodies tm and polypeptides against egfr and igf-ir
US12/083,406 US20090252681A1 (en) 2005-10-11 2006-10-11 Nanobodies and Polypeptides Against EGFR and IGF-IR
JP2008534933A JP2009511032A (en) 2005-10-11 2006-10-11 Nanobodies and polypeptides for EGFR and IGF-IR
AU2006301426A AU2006301426A1 (en) 2005-10-11 2006-10-11 NanobodiesTM and polypeptides against EGFR and IGF-IR

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72593905P 2005-10-11 2005-10-11
US60/725,939 2005-10-11

Publications (2)

Publication Number Publication Date
WO2007042289A2 WO2007042289A2 (en) 2007-04-19
WO2007042289A3 true WO2007042289A3 (en) 2007-10-04

Family

ID=37837037

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/009840 WO2007042289A2 (en) 2005-10-11 2006-10-11 Nanobodies™ and polypeptides against egfr and igf-ir

Country Status (6)

Country Link
EP (1) EP1934259A2 (en)
JP (1) JP2009511032A (en)
CN (1) CN101321784A (en)
AU (1) AU2006301426A1 (en)
CA (1) CA2624781A1 (en)
WO (1) WO2007042289A2 (en)

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Also Published As

Publication number Publication date
CA2624781A1 (en) 2007-04-19
CN101321784A (en) 2008-12-10
EP1934259A2 (en) 2008-06-25
AU2006301426A1 (en) 2007-04-19
JP2009511032A (en) 2009-03-19
WO2007042289A2 (en) 2007-04-19

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