WO2007035734A3 - Cytotoxin compounds and methods of isolation - Google Patents

Cytotoxin compounds and methods of isolation Download PDF

Info

Publication number
WO2007035734A3
WO2007035734A3 PCT/US2006/036484 US2006036484W WO2007035734A3 WO 2007035734 A3 WO2007035734 A3 WO 2007035734A3 US 2006036484 W US2006036484 W US 2006036484W WO 2007035734 A3 WO2007035734 A3 WO 2007035734A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
tunicates
isolation
methods
cell lines
Prior art date
Application number
PCT/US2006/036484
Other languages
French (fr)
Other versions
WO2007035734A2 (en
Inventor
Bill Baker
Thushara Diyabalanage
James B Mcclintock
Charles D Amsler
Original Assignee
Univ South Florida
Uab Research Foundation
Bill Baker
Thushara Diyabalanage
James B Mcclintock
Charles D Amsler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ South Florida, Uab Research Foundation, Bill Baker, Thushara Diyabalanage, James B Mcclintock, Charles D Amsler filed Critical Univ South Florida
Priority to CA002622912A priority Critical patent/CA2622912A1/en
Priority to US12/066,938 priority patent/US8669376B2/en
Priority to AU2006292268A priority patent/AU2006292268A1/en
Priority to EP06825017A priority patent/EP1934196A4/en
Priority to JP2008531434A priority patent/JP2009508878A/en
Publication of WO2007035734A2 publication Critical patent/WO2007035734A2/en
Publication of WO2007035734A3 publication Critical patent/WO2007035734A3/en
Priority to US14/204,996 priority patent/US9394270B2/en
Priority to US15/190,679 priority patent/US10815212B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.
PCT/US2006/036484 2004-02-17 2006-09-18 Cytotoxin compounds and methods of isolation WO2007035734A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002622912A CA2622912A1 (en) 2005-09-16 2006-09-18 Cytotoxin compounds and methods of isolation
US12/066,938 US8669376B2 (en) 2004-02-17 2006-09-18 Cytotoxin compounds and methods of isolation
AU2006292268A AU2006292268A1 (en) 2004-02-17 2006-09-18 Cytotoxin compounds and methods of isolation
EP06825017A EP1934196A4 (en) 2005-09-16 2006-09-18 Cytotoxin compounds and methods of isolation
JP2008531434A JP2009508878A (en) 2005-09-16 2006-09-18 Cytotoxic compounds and isolation methods
US14/204,996 US9394270B2 (en) 2004-02-17 2014-03-11 Cytotoxin compounds and methods of isolation
US15/190,679 US10815212B2 (en) 2004-02-17 2016-06-23 Cytotoxin compounds and methods of isolation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71759805P 2005-09-16 2005-09-16
US60/717,598 2005-09-16

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/906,386 Continuation-In-Part US7625885B2 (en) 2004-02-17 2005-02-17 Cytotoxin compound and method of isolation

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/066,938 A-371-Of-International US8669376B2 (en) 2004-02-17 2006-09-18 Cytotoxin compounds and methods of isolation
US14/204,996 Continuation US9394270B2 (en) 2004-02-17 2014-03-11 Cytotoxin compounds and methods of isolation

Publications (2)

Publication Number Publication Date
WO2007035734A2 WO2007035734A2 (en) 2007-03-29
WO2007035734A3 true WO2007035734A3 (en) 2007-05-03

Family

ID=37889469

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/036484 WO2007035734A2 (en) 2004-02-17 2006-09-18 Cytotoxin compounds and methods of isolation

Country Status (7)

Country Link
EP (1) EP1934196A4 (en)
JP (1) JP2009508878A (en)
KR (1) KR20080059213A (en)
CN (1) CN101277942A (en)
AU (1) AU2006292268A1 (en)
CA (1) CA2622912A1 (en)
WO (1) WO2007035734A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7838691B2 (en) 2007-04-05 2010-11-23 Board Of Regents, Of The University Of Texas System Palmerolides: methods of preparation and derivatives thereof
JP5411264B2 (en) * 2008-07-08 2014-02-12 ソルヴェイ・スペシャルティ・ポリマーズ・イタリー・エッセ・ピ・ア Method for producing fluorosurfactant
WO2012045451A1 (en) 2010-10-05 2012-04-12 Ludwig-Maximilians-Universitaet Muenchen Novel therapeutic treatment of progranulin-dependent diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050187286A1 (en) * 2004-02-17 2005-08-25 University Of South Florida Cytotoxin Compound and Method of Isolation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050187286A1 (en) * 2004-02-17 2005-08-25 University Of South Florida Cytotoxin Compound and Method of Isolation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1934196A4 *

Also Published As

Publication number Publication date
EP1934196A4 (en) 2011-05-18
KR20080059213A (en) 2008-06-26
AU2006292268A1 (en) 2007-03-29
CA2622912A1 (en) 2007-03-29
EP1934196A2 (en) 2008-06-25
WO2007035734A2 (en) 2007-03-29
CN101277942A (en) 2008-10-01
JP2009508878A (en) 2009-03-05

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