WO2007031727A3 - System for delivering neuronal calcium sensor - 1 (ncs - 1) - Google Patents

System for delivering neuronal calcium sensor - 1 (ncs - 1) Download PDF

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Publication number
WO2007031727A3
WO2007031727A3 PCT/GB2006/003367 GB2006003367W WO2007031727A3 WO 2007031727 A3 WO2007031727 A3 WO 2007031727A3 GB 2006003367 W GB2006003367 W GB 2006003367W WO 2007031727 A3 WO2007031727 A3 WO 2007031727A3
Authority
WO
WIPO (PCT)
Prior art keywords
ncs
delivering
calcium sensor
neuronal calcium
neuronal
Prior art date
Application number
PCT/GB2006/003367
Other languages
French (fr)
Other versions
WO2007031727A2 (en
Inventor
Liang-Fong Wong
Nicholas Mazarakis
Susan Kingsman
Ping Yip
Jonathan Corcoran
Stephen Mcmahon
Malcom Maden
Original Assignee
Oxford Biomedica Ltd
King S College London
Liang-Fong Wong
Nicholas Mazarakis
Susan Kingsman
Ping Yip
Jonathan Corcoran
Stephen Mcmahon
Malcom Maden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford Biomedica Ltd, King S College London, Liang-Fong Wong, Nicholas Mazarakis, Susan Kingsman, Ping Yip, Jonathan Corcoran, Stephen Mcmahon, Malcom Maden filed Critical Oxford Biomedica Ltd
Priority to EP06779383A priority Critical patent/EP1937820A2/en
Publication of WO2007031727A2 publication Critical patent/WO2007031727A2/en
Publication of WO2007031727A3 publication Critical patent/WO2007031727A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4728—Calcium binding proteins, e.g. calmodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15045—Special targeting system for viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
    • C12N2810/6072—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses
    • C12N2810/6081—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses rhabdoviridae, e.g. VSV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides a system capable of delivering neuronal calcium sensor-1 (NCS-1), or a nucleotide sequence encoding NCS-1 to a target cell, for promoting neurite outgrowth. The system may be used in the manufacture of a pharmaceutical composition for the treatment of a condition such as spinal cord injury.
PCT/GB2006/003367 2005-09-13 2006-09-11 System for delivering neuronal calcium sensor - 1 (ncs - 1) WO2007031727A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06779383A EP1937820A2 (en) 2005-09-13 2006-09-11 System for delivering neuronal calcium sensor-1 (ncs-1)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0518674.7 2005-09-13
GB0518674A GB0518674D0 (en) 2005-09-13 2005-09-13 System

Publications (2)

Publication Number Publication Date
WO2007031727A2 WO2007031727A2 (en) 2007-03-22
WO2007031727A3 true WO2007031727A3 (en) 2008-05-15

Family

ID=35221413

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/003367 WO2007031727A2 (en) 2005-09-13 2006-09-11 System for delivering neuronal calcium sensor - 1 (ncs - 1)

Country Status (3)

Country Link
EP (1) EP1937820A2 (en)
GB (1) GB0518674D0 (en)
WO (1) WO2007031727A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10639384B2 (en) 2016-03-23 2020-05-05 Inserm (Institut National De La Sante Et De La Recherche Medicale) Targeting the neuronal calcium sensor 1 for treating wolfram syndrome
CN112852976B (en) * 2021-03-17 2023-10-31 湖北省农业科学院畜牧兽医研究所 Molecular marker related to later egg laying characteristics in NCS1 gene of laying hen and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001075135A1 (en) * 2000-03-30 2001-10-11 Oxford Biomedica (Uk) Limited Retinoic acid receptor beta-2, its antagonists, and gene therapy vectors for the treatment of neurological disorders
EP1250931A1 (en) * 2001-04-17 2002-10-23 F. Hoffmann-La Roche Ag Novel use of neuronal calcium sensor-1 (NCS-1) in therapy of CNS disorders and in the development of therapeutic agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001075135A1 (en) * 2000-03-30 2001-10-11 Oxford Biomedica (Uk) Limited Retinoic acid receptor beta-2, its antagonists, and gene therapy vectors for the treatment of neurological disorders
EP1250931A1 (en) * 2001-04-17 2002-10-23 F. Hoffmann-La Roche Ag Novel use of neuronal calcium sensor-1 (NCS-1) in therapy of CNS disorders and in the development of therapeutic agents

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KAWASAKI T, ET AL.: "SPATIOTEMPORAL DISTRIBUTION OF NEURONAL CALCIUM SENSOR-1 IN THE DEVELOPING RAT SPINAL CORD", THE JOURNAL OF COMPARATIVE NEUROLOGY, vol. 460, 2003, pages 465 - 475, XP009076437 *
NAKAMURA T Y, ET AL.: "NOVEL ROLE OF NEURONAL CA2+ SENSOR-1 AS A SURVIVAL FACTOR UP-REGULATED IN INJURED NEURONS", THE JOURNAL OF CELL BIOLOGY, vol. 172, no. 7, 27 March 2006 (2006-03-27), pages 1081 - 1091, XP002412312 *
PAN C-Y, ET AL.: "ALTERATIONS IN EXOCYTOSIS INDUCED BY NEURONAL CA2+ SENSOR-1 IN BOVINE CHROMAFFIN CELLS", THE JOURNAL OF NEUROSCIENCE, vol. 22, no. 7, 2002, pages 2427 - 2433, XP002412311 *

Also Published As

Publication number Publication date
EP1937820A2 (en) 2008-07-02
GB0518674D0 (en) 2005-10-19
WO2007031727A2 (en) 2007-03-22

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