WO2007025989A3 - Nucleic acid variants in the toll like receptor genes associated with altered innate immunity - Google Patents

Nucleic acid variants in the toll like receptor genes associated with altered innate immunity Download PDF

Info

Publication number
WO2007025989A3
WO2007025989A3 PCT/EP2006/065821 EP2006065821W WO2007025989A3 WO 2007025989 A3 WO2007025989 A3 WO 2007025989A3 EP 2006065821 W EP2006065821 W EP 2006065821W WO 2007025989 A3 WO2007025989 A3 WO 2007025989A3
Authority
WO
WIPO (PCT)
Prior art keywords
toll
nucleic acid
innate immunity
genes associated
acid variants
Prior art date
Application number
PCT/EP2006/065821
Other languages
French (fr)
Other versions
WO2007025989A2 (en
Inventor
Lieve Nuytinck
Original Assignee
Innogenetics Nv
Lieve Nuytinck
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics Nv, Lieve Nuytinck filed Critical Innogenetics Nv
Priority to EP06806736A priority Critical patent/EP1931801A2/en
Publication of WO2007025989A2 publication Critical patent/WO2007025989A2/en
Publication of WO2007025989A3 publication Critical patent/WO2007025989A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

The present invention relates to a method and kit for identifying a subject at risk of, or having, an indication associated with altered innate immunity. The present invention is based on the determination of Toll Like Receptor (TLR) genotypes and/or serum levels.
PCT/EP2006/065821 2005-09-02 2006-08-30 Nucleic acid variants in the toll like receptor genes associated with altered innate immunity WO2007025989A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06806736A EP1931801A2 (en) 2005-09-02 2006-08-30 Nucleic acid variants in the toll like receptor genes associated with altered innate immunity

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05108074 2005-09-02
EP05108074.5 2005-09-02
US71752705P 2005-09-15 2005-09-15
US60/717,527 2005-09-15

Publications (2)

Publication Number Publication Date
WO2007025989A2 WO2007025989A2 (en) 2007-03-08
WO2007025989A3 true WO2007025989A3 (en) 2007-08-23

Family

ID=36128627

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/065821 WO2007025989A2 (en) 2005-09-02 2006-08-30 Nucleic acid variants in the toll like receptor genes associated with altered innate immunity

Country Status (2)

Country Link
EP (1) EP1931801A2 (en)
WO (1) WO2007025989A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9580752B2 (en) 2008-12-24 2017-02-28 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8335652B2 (en) 2004-06-23 2012-12-18 Yougene Corp. Self-improving identification method
US11268149B2 (en) 2004-12-08 2022-03-08 Cedars-Sinai Medical Center Diagnosis and treatment of inflammatory bowel disease
US10544459B2 (en) 2004-12-08 2020-01-28 Cedars-Sinai Medical Center Methods of using genetic variants for the diagnosis and treatment of inflammatory bowel disease
WO2008107377A2 (en) * 2007-03-02 2008-09-12 Innogenetics N.V. Combinations of markers for sepsis risk assessment
US20100311052A1 (en) * 2007-06-29 2010-12-09 Biomonitor A/S Prognostic method for the determination of the suitability of biopharmaceutical treatment
WO2010062960A2 (en) 2008-11-26 2010-06-03 Cedars-Sinai Medical Center METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE
EP4285988A3 (en) 2013-03-27 2024-03-06 Cedars-Sinai Medical Center Treating fibrosis by inhibiting tl1a
EP3022295A4 (en) 2013-07-19 2017-03-01 Cedars-Sinai Medical Center Signature of tl1a (tnfsf15) signaling pathway
KR20220153109A (en) 2016-03-17 2022-11-17 세다르스-신나이 메디칼 센터 Methods of diagnosing inflammatory bowel disease through rnaset2
CN114182007B (en) * 2021-12-08 2023-11-24 上海锐翌医学检验实验室有限公司 Behcet disease marker gene and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003050137A2 (en) * 2001-12-11 2003-06-19 David Schwartz Toll-like receptor 4 mutations

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003050137A2 (en) * 2001-12-11 2003-06-19 David Schwartz Toll-like receptor 4 mutations

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BOCHUD P.-Y. ET AL.,: "cutting edge: a toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling", JOURNAL OF IMMUNOLOGY, vol. 170, 2003, pages 3451 - 3454, XP002377352 *
GOLDSTEIN D. R.: "toll-like receptors and other links between innate and acquired alloimmunity", CURRENT OPINION IN IMMUNOLOGY, vol. 16, 2004, pages 538 - 544, XP002377353 *
HAERTEL CH. ET. AL.,: "polymorphisms of genes involved in innate immunity: association with preterm delivery", MOLECULAR HUMAN REPRODUCTION, vol. 12, no. 10, 29 October 2004 (2004-10-29), pages 911 - 915, XP009065437 *
LAZARUS R. ET AL.: "Toll-like receptor 10 genetic variation is associated with asthma in two independent samples", AM. J. RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 170, 2004, pages 594 - 600, XP002377355 *
LORENZ E ET AL: "RELEVANCE OF MUTATIONS IN THE TLR4 RECEPTOR IN PATIENTS WITH GRAM-NEGATIVE SEPTIC SHOCK", ARCHIVES OF INTERNAL MEDICINE, AMERICAN MEDICAL ASSOCIATION, CHICAGO, IL, US, vol. 162, no. 9, 15 May 2002 (2002-05-15), pages 1028 - 1032, XP008041705, ISSN: 0003-9926 *
LORENZ E. ET AL.,: "a novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection", INFECTION AND IMMUNITY, vol. 68, no. 11, November 2000 (2000-11-01), pages 6398 - 6401, XP002377354 *
MORRE S A ET AL: "Role of the toll-like receptor 4 Asp299Gly polymorphism in susceptibility to Candida albicans infection", JOURNAL OF INFECTIOUS DISEASES, CHICAGO, IL, US, vol. 186, 1 November 2002 (2002-11-01), pages 1377 - 1379, XP002904767, ISSN: 0022-1899 *
SCHROEDER N. W.J. & SCHUMANN R.R.: "single nucleotide polymorphisms of toll-like receptors and susceptibility to infectious disease", LANCET INFECT DIS., vol. 5, March 2005 (2005-03-01), pages 156 - 164, XP002377357 *
SUN J. ET AL.,: "sequence variants in toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk", J. NATIONAL CANCER INSTITUTE, vol. 97, no. 7, 6 April 2005 (2005-04-06), pages 525 - 532, XP002377356 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9580752B2 (en) 2008-12-24 2017-02-28 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy

Also Published As

Publication number Publication date
WO2007025989A2 (en) 2007-03-08
EP1931801A2 (en) 2008-06-18

Similar Documents

Publication Publication Date Title
WO2007025989A3 (en) Nucleic acid variants in the toll like receptor genes associated with altered innate immunity
WO2006089091A3 (en) Methods for detecting minimum residual disease
WO2005087951A3 (en) Reagents, methods and kits for use in deactivating nucleic acids
WO2006117161A3 (en) New labelling strategies for the sensitive detection of analytes
WO2006007980A3 (en) Esr1 and cervical cancer
WO2008064131A3 (en) Device and process for unique internet access identification
WO2010002883A3 (en) Methods and devices for single-molecule whole genome analysis
WO2009100188A3 (en) Methods for detection of corn event das-59132
WO2005080594A3 (en) Method for determining the risk of developing a neurological disease
WO2007023148A3 (en) Nucleic acid variants in the lbp gene associated with altered innate immunity
WO2008136988A3 (en) Polymorphisms in genes affecting cyp2c9-related disorders and uses thereof
WO2008135929A3 (en) Colorimetric method and kit for the detection of specific nucleic acid sequences using metal nanoparticles functionalized with modified oligonucleotides
WO2007086980A3 (en) Methods of determining the risk of developing coronary artery disease
WO2007097574A8 (en) Molecular marker associated with tmv resistance and use thereof
WO2008076856A3 (en) Reagents and methods for detecting cyp2d6 polymorphisms
WO2005100611A3 (en) Detection of viral nucleic acid and method for reverse transcribing rna
WO2005118872A3 (en) Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases
WO2010051214A8 (en) Compositions and methods for detecting mutations in jak2 nucleic acid
WO2006099537A3 (en) The use of antibody-surrogate antigen systems for detection of analytes
WO2005035720A3 (en) Methods and use of binding components for improving assay specificity
WO2006060739A3 (en) Ubiquitin ligase assays and related reagents
WO2008056144A3 (en) Methods for detecting toluene and xylene using as biosensor a tranformed acinetobacter baylyi adp1
WO2007060671A3 (en) Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis
EP1829979A4 (en) Method of identifying gene with variable expression
WO2004000995A3 (en) Methods, probes, and accessory molecules for detecting single nucleotide polymorphisms

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2006806736

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2006806736

Country of ref document: EP