WO2007016209A3 - Pure 1,2-benzisoxazole-3-methane-sulfonic acid sodium salt and purification process - Google Patents

Pure 1,2-benzisoxazole-3-methane-sulfonic acid sodium salt and purification process Download PDF

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Publication number
WO2007016209A3
WO2007016209A3 PCT/US2006/029121 US2006029121W WO2007016209A3 WO 2007016209 A3 WO2007016209 A3 WO 2007016209A3 US 2006029121 W US2006029121 W US 2006029121W WO 2007016209 A3 WO2007016209 A3 WO 2007016209A3
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WO
WIPO (PCT)
Prior art keywords
methane
sulfonic acid
sodium salt
benzisoxazole
chemically pure
Prior art date
Application number
PCT/US2006/029121
Other languages
French (fr)
Other versions
WO2007016209A2 (en
Inventor
Marioara Mendelovici
Natalia Shenkar
Original Assignee
Teva Pharma
Marioara Mendelovici
Natalia Shenkar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma, Marioara Mendelovici, Natalia Shenkar filed Critical Teva Pharma
Publication of WO2007016209A2 publication Critical patent/WO2007016209A2/en
Publication of WO2007016209A3 publication Critical patent/WO2007016209A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

The present invention provides chemically pure sodium salt of 1,2-benzisoxazofe-3-methane-sulfonic acid, the sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid of high assay, or chemically pure sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid of high assay, and processes for preparing the same via purification. The present invention also provides monohydrate form of the chemically pure sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid, the sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid of high assay, or chemically pure sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid of high assay. Furthermore, the present invention provides anhydrous form of the chemically pure sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid, the sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid of high assay, or chemically pure sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid of high assay. One of the embodiments of the present invention is directed to a process for preparing zonisamide using the chemically pure sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid, the sodium salt of 1,2-benzisoxazole-3- methane-sulfonic acid of high assay, or chemically pure sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid of high assay.
PCT/US2006/029121 2005-07-28 2006-07-28 Pure 1,2-benzisoxazole-3-methane-sulfonic acid sodium salt and purification process WO2007016209A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70299405P 2005-07-28 2005-07-28
US60/702,994 2005-07-28

Publications (2)

Publication Number Publication Date
WO2007016209A2 WO2007016209A2 (en) 2007-02-08
WO2007016209A3 true WO2007016209A3 (en) 2007-04-12

Family

ID=37526989

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/029121 WO2007016209A2 (en) 2005-07-28 2006-07-28 Pure 1,2-benzisoxazole-3-methane-sulfonic acid sodium salt and purification process

Country Status (1)

Country Link
WO (1) WO2007016209A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003072552A1 (en) * 2002-02-22 2003-09-04 Teva Pharmaceutical Industries Ltd. Method for preparing benzisoxazole methane sulfonyl chloride and its amidation to form zonisamide
WO2004020419A1 (en) * 2002-08-29 2004-03-11 Teva Pharmaceutical Industries Ltd. Novel sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms
WO2005030738A1 (en) * 2003-09-29 2005-04-07 Suven Life Sciences Limited Improved process for the preparation of intermediates useful for the preparation of zonisamide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003072552A1 (en) * 2002-02-22 2003-09-04 Teva Pharmaceutical Industries Ltd. Method for preparing benzisoxazole methane sulfonyl chloride and its amidation to form zonisamide
WO2004020419A1 (en) * 2002-08-29 2004-03-11 Teva Pharmaceutical Industries Ltd. Novel sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms
WO2005030738A1 (en) * 2003-09-29 2005-04-07 Suven Life Sciences Limited Improved process for the preparation of intermediates useful for the preparation of zonisamide

Also Published As

Publication number Publication date
WO2007016209A2 (en) 2007-02-08

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