WO2007013894A3 - Phospholipid ether analogs for detecting and treating cancer - Google Patents

Phospholipid ether analogs for detecting and treating cancer Download PDF

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Publication number
WO2007013894A3
WO2007013894A3 PCT/US2005/047657 US2005047657W WO2007013894A3 WO 2007013894 A3 WO2007013894 A3 WO 2007013894A3 US 2005047657 W US2005047657 W US 2005047657W WO 2007013894 A3 WO2007013894 A3 WO 2007013894A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
detecting
phospholipid ether
ether analogs
treating cancer
Prior art date
Application number
PCT/US2005/047657
Other languages
French (fr)
Other versions
WO2007013894A9 (en
WO2007013894A2 (en
Inventor
Jamey Weichert
Marc Longino
Anatoly Pinchuk
Original Assignee
Cellectar Llc
Jamey Weichert
Marc Longino
Anatoly Pinchuk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellectar Llc, Jamey Weichert, Marc Longino, Anatoly Pinchuk filed Critical Cellectar Llc
Priority to EP05858499A priority Critical patent/EP1833514A2/en
Priority to MX2007007497A priority patent/MX2007007497A/en
Priority to JP2007548624A priority patent/JP2008545614A/en
Priority to CA002591907A priority patent/CA2591907A1/en
Priority to US11/382,645 priority patent/US7632644B2/en
Publication of WO2007013894A2 publication Critical patent/WO2007013894A2/en
Publication of WO2007013894A9 publication Critical patent/WO2007013894A9/en
Publication of WO2007013894A3 publication Critical patent/WO2007013894A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides methods for treating, detecting and locating recurrence of cancer, radiation and chemo insensitive cancer or metastasis of cancer selected from the group consisting of Lung cancer, Adrenal cancer, Melanoma, Colon cancer, Colorectal cancer, Ovarian cancer, Prostate cancer, Liver cancer, Subcutaneous cancer, Squamous cell cancer, Intestinal cancer, Hepatocellular carcinoma, Retinoblastoma,Cervical cancer, Glioma, Breast cancer and Pancreatic cancer in subject using phospholipid ether analogs
PCT/US2005/047657 2004-03-02 2005-12-20 Phospholipid ether analogs for detecting and treating cancer WO2007013894A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP05858499A EP1833514A2 (en) 2004-12-20 2005-12-20 Phospholipid ether analogs for detecting and treating cancer
MX2007007497A MX2007007497A (en) 2004-12-20 2005-12-20 Phospholipid ether analogs for detecting and treating cancer.
JP2007548624A JP2008545614A (en) 2004-12-20 2005-12-20 Phospholipid ether analogs for cancer detection and therapy
CA002591907A CA2591907A1 (en) 2004-12-20 2005-12-20 Phospholipid ether analogs for detecting and treating cancer
US11/382,645 US7632644B2 (en) 2004-03-02 2006-05-10 Imaging and selective retention of phospholipid ether analogs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59319004P 2004-12-20 2004-12-20
US60/593,190 2004-12-20

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/006681 Continuation-In-Part WO2005084716A2 (en) 2004-03-02 2005-03-02 Phospholipid analogs for diagnosis and treatment of cancer

Related Child Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2005/024259 Continuation-In-Part WO2006014589A2 (en) 2004-03-02 2005-07-08 Virtual colonoscopy with radiolabeled phospholipid ether analogs
US11/382,645 Continuation-In-Part US7632644B2 (en) 2004-03-02 2006-05-10 Imaging and selective retention of phospholipid ether analogs

Publications (3)

Publication Number Publication Date
WO2007013894A2 WO2007013894A2 (en) 2007-02-01
WO2007013894A9 WO2007013894A9 (en) 2007-03-29
WO2007013894A3 true WO2007013894A3 (en) 2007-04-19

Family

ID=37564093

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/047657 WO2007013894A2 (en) 2004-03-02 2005-12-20 Phospholipid ether analogs for detecting and treating cancer

Country Status (6)

Country Link
EP (1) EP1833514A2 (en)
JP (1) JP2008545614A (en)
KR (1) KR20080005178A (en)
CA (1) CA2591907A1 (en)
MX (1) MX2007007497A (en)
WO (1) WO2007013894A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8540968B2 (en) 2004-03-02 2013-09-24 Cellectar, Inc. Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof
EP2044960B1 (en) * 2004-03-02 2013-11-20 Cellectar, Inc. Phospholipid analogue for the in vivo diagnosis of cancers
AU2005269861A1 (en) * 2004-07-08 2006-02-09 Cellectar, Llc Virtual colonoscopy with radiolabeled phospholipid ether analogs
WO2010132428A1 (en) * 2009-05-11 2010-11-18 Cellectar, Inc. Fluorescent phospholipid ether compounds, compositions, and methods of use
ES2799411T3 (en) 2009-06-12 2020-12-17 Cellectar Inc Alkylphospholipid compounds for cancer treatment and cancer stem cell imaging and detection
US20110064661A1 (en) * 2009-09-11 2011-03-17 Pinchuk Anatoly Non-radioactive phospholipid compounds, compositions, and methods of use
PT3229810T (en) * 2014-11-17 2020-08-27 Cellectar Biosciences Inc Phospholipid ether analogs as cancer-targeting drug vehicles
JP6666757B2 (en) * 2016-03-10 2020-03-18 日本メジフィジックス株式会社 Method for quantifying polyoxyethylene nonionic surfactant and method for producing radiopharmaceutical preparation
NZ749272A (en) * 2016-06-14 2023-01-27 Cellectar Biosciences Inc Phospholipid ether analogs for the identification and isolation of circulating tumor cells
EP3484513B1 (en) * 2016-07-18 2023-06-07 Wisconsin Alumni Research Foundation Radiohalogenated agents for combined cancer therapy
US11633506B2 (en) 2016-07-18 2023-04-25 Wisconsin Alumni Research Foundation Using targeted radiotherapy (TRT) to drive anti-tumor immune response to immunotherapies
CA3031776C (en) * 2016-07-25 2024-02-20 Wisconsin Alumni Research Foundation Targeted radiotherapy chelates for in situ immune modulated cancer vaccination
KR20200088374A (en) * 2017-11-10 2020-07-22 위스콘신 얼럼나이 리서어치 화운데이션 Methods of using targeted radiotherapy (TRT) to induce an anti-tumor immune response to immunotherapy
CA3096677A1 (en) * 2018-04-10 2019-10-17 Cellectar Biosciences, Inc. Fractionated dosing of a phospholipid ether analog for the treatment of cancer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024480A1 (en) * 1996-12-04 1998-06-11 The Regents Of The University Of Michigan Radioiodinated phospholipid ether analogs and methods of using the same
US5795561A (en) * 1987-10-23 1998-08-18 The Board Of Regents Of The University Of Michigan Radioiodinated phospholipid ether analogues
WO2005084716A2 (en) * 2004-03-02 2005-09-15 Cellectar, Llc Phospholipid analogs for diagnosis and treatment of cancer
WO2006014589A2 (en) * 2004-07-08 2006-02-09 Cellectar, Llc Virtual colonoscopy with radiolabeled phospholipid ether analogs

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795561A (en) * 1987-10-23 1998-08-18 The Board Of Regents Of The University Of Michigan Radioiodinated phospholipid ether analogues
WO1998024480A1 (en) * 1996-12-04 1998-06-11 The Regents Of The University Of Michigan Radioiodinated phospholipid ether analogs and methods of using the same
WO2005084716A2 (en) * 2004-03-02 2005-09-15 Cellectar, Llc Phospholipid analogs for diagnosis and treatment of cancer
WO2006014589A2 (en) * 2004-07-08 2006-02-09 Cellectar, Llc Virtual colonoscopy with radiolabeled phospholipid ether analogs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WEICHERT J P ET AL: "Initial Clinical Imaging Results with NM404 in Non-Small Cell Lung Cancer", MOLECULAR IMAGING, MIT PRESS,, US, vol. 3, no. 3, July 2004 (2004-07-01), pages 269 - 270, XP002365141, ISSN: 1535-3508 *

Also Published As

Publication number Publication date
EP1833514A2 (en) 2007-09-19
CA2591907A1 (en) 2007-02-01
KR20080005178A (en) 2008-01-10
JP2008545614A (en) 2008-12-18
MX2007007497A (en) 2008-01-11
WO2007013894A9 (en) 2007-03-29
WO2007013894A2 (en) 2007-02-01

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