WO2007009414A1 - Systeme constitue d'un instrument de prelevement servant a prelever des cellules ou a appliquer des preparations et dispositif de logement pour ledit instrument - Google Patents

Systeme constitue d'un instrument de prelevement servant a prelever des cellules ou a appliquer des preparations et dispositif de logement pour ledit instrument Download PDF

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Publication number
WO2007009414A1
WO2007009414A1 PCT/DE2006/001084 DE2006001084W WO2007009414A1 WO 2007009414 A1 WO2007009414 A1 WO 2007009414A1 DE 2006001084 W DE2006001084 W DE 2006001084W WO 2007009414 A1 WO2007009414 A1 WO 2007009414A1
Authority
WO
WIPO (PCT)
Prior art keywords
receiving device
cell
receiving
receiving area
instrument
Prior art date
Application number
PCT/DE2006/001084
Other languages
German (de)
English (en)
Inventor
Abdolhamid Huschmand Nia
Reinhold Wegener
Original Assignee
Georg-August-Universität Göttingen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georg-August-Universität Göttingen filed Critical Georg-August-Universität Göttingen
Publication of WO2007009414A1 publication Critical patent/WO2007009414A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
    • A61M35/006—Portable hand-held applicators having means for dispensing or spreading integral media using sponges, foams, absorbent pads or swabs as spreading means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0096—Casings for storing test samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0291—Instruments for taking cell samples or for biopsy for uterus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/03—Automatic limiting or abutting means, e.g. for safety
    • A61B2090/037—Automatic limiting or abutting means, e.g. for safety with a frangible part, e.g. by reduced diameter

Definitions

  • the invention relates to a system with a smear instrument for the removal of cells or material samples or the application of preparations and a receiving device for the smear instrument.
  • a cytological sampler which has a holder, at the front end of which a conical, foam-covered tip is formed.
  • This tip can be introduced into the cervix to accommodate cells with a low traumatic effect, where they can take in the cells they desire.
  • you remove bacteria and other microorganisms they would usually first be grown in a suitable nutrient medium.
  • the samples taken are either immediately transferred to a plate with a nutrient medium or preincubated in a glass tube with a nutrient medium for later transfer to one or more plates for analysis.
  • the transfer to a second tube costs time and money.
  • the object of the present invention is to provide a system with which it can be ensured in a simple manner after a cell removal that the removed cells can be optimally stored, transported and further treated. For this purpose, it must be possible to preincubate the removed cells under air in a transport tube. Also, centrifugation on a smear instrument inserted in the transport tube should be possible to remove the cells or material samples from the foam. Furthermore, an application of preparations on skin or wound surfaces should be possible via a soaked in the preparation receiving area, the preparation should be well protected before applying as possible.
  • the system according to the invention with a stent removal instrument and a stool retrieval device provides that the stool instrument comprises a holder having a front and a rear end. At the front end is a cell or
  • Specimen receiving area arranged at the rear end is a
  • the receiving device for the smear instrument has an insertion opening for at least the cell or specimen receiving area and enclosing the cell or specimen receiving area, wherein a rear
  • the handle element facing cooperates with the receiving device in such a way that a closed chamber is formed, in which at a complete insertion of the smear instrument in the receiving device at least a front part of the cell or specimen receiving area is added.
  • the smear instrument with most of the holder and the cell or specimen receiving area is thus inserted into the receiving device and closed by the gripping element, which is arranged at the rear part of the holder, so that a closed chamber is formed.
  • the other application of the invention provides for the application of preparations or medicaments which are taken up via the cell or specimen receiving area and stored protected in the chamber until use.
  • the smear instrument which is then used as an application instrument, is removed from the receiving device and stroked or rolled on the surface to be treated.
  • a cell receiving area which also includes a specimen receiving area is detected.
  • the applications and advantages in the storage or storage of cell or tissue samples can be transferred to the preparations accordingly.
  • the structural conditions can be taken accordingly.
  • a development of the invention provides that the rear end of the cell receiving area is formed as a dimensionally stable carrier to a
  • the cell receiving area which may be formed as a soft foam tip to allow.
  • the dimensionally stable offers Carrier at the same time a protective function when the smear instrument is inserted in the receiving device.
  • a very good storage and preservation of the removed sample material is achieved in that the carrier of the foam tip has a peripheral edge, which rests in fully inserted state of the smear instrument in the press fit on the inside of the receiving device.
  • a very small, second chamber is formed, which is closed by the support of the foam tip.
  • this chamber is filled almost exclusively by the foam tip, if necessary, a small volume is provided for a nutrient medium.
  • a peripheral receiving groove is provided on the inside of the receiving device, in which a circumferential edge of the carrier engages positively in the fully inserted state. Due to the yielding or latching of the peripheral edge of the carrier into the receiving groove, both a haptic and acoustic signal is sent to the user of the system that the chamber is closed in the front end of the receiving device.
  • the chambers are preferably airtight in the closed state, wherein the airtight seal can be brought about both by the carrier and by the handle element.
  • At least one predetermined breaking point may be arranged between the gripping element and the cell or specimen receiving area, which makes it possible to separate the holder with the gripping element from the cell receiving area at a predetermined location in order to reduce the length of the system.
  • a predetermined breaking point is formed in the receiving device in order to be able to break it off if, for example, only the front region with the hermetically sealed cell receiving region is required in order to store the cells in the longer term.
  • the receiving device is preferably designed as a closed-end tube, for example plastic or glass tube.
  • the system will be equipped with a smear instrument for the removal of cells and a pick-up device for the smear instrument.
  • the smear instrument comprises a holder having a front end and a rear end. At the front end, a cell receiving area is arranged, while at the rear end a handle member is arranged.
  • the receiving device for the smear instrument has an insertion opening for at least the cell receiving area and enclosing the cell receiving area.
  • a sealing region in particular a closing edge is formed, which shoots flush with a sealing surface on the handle member in the fully inserted state of the smear instrument, so as to provide a closed chamber in which the cell receiving area is taken protected against environmental influences together with the holder.
  • a development of the invention provides that the sealing surface is formed as a shoulder, which rests on a front-side end edge, in order to achieve a secure and airtight closure in the fully closed state.
  • a locking device is formed on the handle element, which engages in a form-fitting manner in a second-off engagement device on the receiving device.
  • This makes it possible to fix the gripping element positively on the receiving device, for example via a threaded portion in the form of a screwing movement or via undercuts, which are overcome by a compressive force, so that the gripping element engages or clipped in the Recording device is received.
  • the locking device may be formed as a projection which engages in the engaging device designed as a recess, wherein the recess is designed such that in a first position, the grip element is fixed to the receiving device, but the grip element does not yet sealingly rests on the end edge. In a second position of the grip element, this lies sealingly on the sealing area or the closing edge and closes the receiving device.
  • a rear end of the cell receiving area which faces the gripping element, to cooperate with the receiving device in such a way that a closed chamber is formed in which at least one front part of the cell receiving area is received when the smear instrument is completely inserted into the receiving device is.
  • the closed chamber is formed by the cooperation of a dimensionally stable carrier on the back of the cell receiving area, which may be formed as a conical foam tip or as a foam cone.
  • the carrier is seated with its peripheral edge in an interference fit on the inside of the receiving device and may be inserted into a circumferential receiving groove to ensure an airtight seal and a sealed transport of the removed cell sample.
  • a peripheral edge of the carrier in the completely inserted state can engage positively in a receiving groove arranged in the receiving device on the inside.
  • Both the chamber formed by the gripping member in conjunction with the receiving device and the chamber formed by the carrier in cooperation with the receiving device may be hermetically sealed.
  • At least one predetermined breaking point may be arranged in the holder between the gripping element and the cell receiving region in order to be able to produce a shorter length of the smear instrument, if appropriate
  • the cell receiving area should be sealed airtight in the receiving device only by the carrier.
  • a predetermined breaking point is also formed on the receiving device, which is formed between the insertion opening and the rear end of the cell receiving portion of the smear instrument in the fully inserted state.
  • the locking device and the engagement device may be designed as a snap closure, so that the smear instrument only has to be pressed into the receiving device.
  • a further embodiment of the system provides that projections are arranged on the grip element in axial extension in the direction of the cell receiving region and in the circumferential direction. Also in the axial extension of the insertion away radial recesses are formed in the receiving device, which are offset from each other in the circumferential direction and are formed or arranged so that the projections which are formed on the handle member are received in the recesses.
  • the offset in the axial direction makes it possible for the gripping element to be introduced stepwise into the receiving device, wherein each recess forms a stop on which the correspondingly arranged and formed projection rests.
  • the smear instrument By rotating the handle member and inserting the front projection in the direction of the cell receiving area into the recess further away from the insertion opening, the smear instrument can be completely inserted into the receiving device.
  • This device allows a staged insertion of the smear instrument, so that the handle element does not rest completely sealingly on the sealing area or the terminal edge when the front projection is inserted in the recess closest to the insertion opening.
  • the smear instrument can be fully inserted.
  • Figure 1 - a detailed view of a smear instrument in partially inserted state
  • FIG. 2 shows a partial drawing of a smear instrument completely inserted into a receiving device
  • FIG. 3 shows a completely introduced smear instrument in a receiving device in a perspective partial sectional view
  • Figure 4 - a partially inserted into a receiving device
  • Figure 5 - a partially inserted into a receiving device smear instrument in a perspective partial sectional view with twisted smear instrument
  • FIG. 6 shows a partially closed receiving device with an introduced smear instrument in the position according to FIG. 5;
  • FIG. 7 shows an outside view according to FIG. 6; such as
  • Figure 8 an alternative embodiment of the system in the closed state.
  • FIG. 1 shows a swab instrument 1 which has a holder 10, at the rear end 12 of which a grip element 13 is arranged.
  • the holder 10 is rod-shaped, the rear end 12 opposite the front end 11 is not visible in this partial view.
  • the smear instrument 1 is in a Recording device 2 introduced, which is partially cut for clarity.
  • the receiving device 2 is essentially a unilaterally open, conically tapered to the closed end tube into which the holder 10 can be inserted together with a part of the handle member 13.
  • the grip element 13 is substantially cylindrical and widens radially so that a sealing surface 130 in the form of a shoulder is formed. Offset to the sealing surface 130 radially inwardly a socket 135 is formed in a cylindrical shape to the axial extension, facing away from the handle member 13, locking devices 133, 134 extend, which are presently formed as perpendicular to each other aligned projections with an oval base.
  • the projections 133, 134 are offset in the circumferential direction and axially along the longitudinal axis of the holder 10 to each other.
  • FIG. 1 In the left-hand illustration of FIG. 1 it can be seen that the smear instrument 1 with the holder 10 is inserted in the receiving device 2, but the lower edge of the projection 134 rests on a supporting edge 233 'of an engagement device, so that between the base 135 of the gripping element 13 and a terminal edge 25 of the receiving device, a gap is formed, can pass through the air in the partially sealed chamber 3 within the receiving device 2.
  • a nutrient fluid can be introduced into the chamber 3 for preincubation. In this condition, incubation or centrifugation can be performed.
  • the smear instrument 1 In the illustrated position, the smear instrument 1 is on the one hand firmly mounted on the receiving device 2, on the other hand, an exchange of air take place.
  • the smear instrument 1 is rotated by 90 °, so that the locking device 134 is aligned with a corresponding engagement device 234, as shown in FIG.
  • the lower edge of the Locking device 134 no longer on the edge 233 'of the upper, the insertion opening 20 facing engagement device 233, so that the entire smear instrument 1 can slide into the receiving device 2 further.
  • the locking device 133 is then on the edge 233 ', at the same time closes the cylindrical base 135 flush with the upper part of the receiving device 2, while the sealing surface 130 sealingly rests on the end edge 25.
  • the insertion opening 20 of the receiving device 2 is completely and tightly closed, so that the recorded tissue or the recorded cells can be transported or stored within the chamber 3 without an exchange of air with the environment.
  • the sealing effect can also be realized by the base 135 and a peripheral edge of the receiving device 2.
  • FIG. 3 shows the completely introduced smear instrument 1 in an overall view.
  • a carrier 15 is formed as a plate-shaped support, which is not shown
  • Foam tip carries which can be introduced for cell uptake in a body opening. After the cell uptake, the smear instrument 1 is completely inserted into the receiving device 2, as shown in the left-hand illustration of FIG.
  • a predetermined breaking point 17 is formed, on which the grip element 13 and the rear part of the holder 10 can be canceled in order to reduce the length of the holder 10. Also, a predetermined breaking point 24 is formed on the receiving device 2 in order to shorten the receiving device 2 if necessary.
  • the tapered to the front end shape of the receiving device 2 is further to recognize.
  • FIG. 4 an alignment of the swab instrument 1 is shown in which the protrusions 133, 134 are allowed to be inserted into the corresponding engagement means or recesses 233, 234, so that the swab instrument 1 is completely inserted into the direction of movement by displacement in the direction of the arrow Recording device can be introduced.
  • the base 135 is also fully inserted into the insertion opening 20 until the sealing surface 130 sealingly rests on the end edge 25.
  • FIG. 5 an alignment of the smear instrument 1 is shown in which, in the case of an insertion movement in the direction of the arrow, the locking device 134 would seat on the edge 233 ', so that a gap 5 would be left open.
  • This gap 5 is shown in FIG.
  • the foam tip 16, which is preferably conical, is fastened to the carrier 15, so that a cell receiving region 14 is formed at the front end 11 of the carrier 10.
  • FIG. 7 shows an overall view of the system with the smear instrument 1 and the receiving device 2, the smear instrument 1 being accommodated in the receiving device 2, leaving a gap 5 free.
  • the base 135 is still above the end edge 25 and allows air circulation.
  • the predetermined breaking point 24 is as a material weakening in the front, closed area of the receiving device 2, the Plastic or other suitable material may be formed.
  • FIG. 8 shows a variant of the invention in which the grip area 13 rests flush with the sealing edge 130 on the terminal edge 25.
  • Receiving groove 23 is formed, in which the peripheral edge 150 of the carrier 15 can engage positively. This allows not only a particularly tight conclusion but also an acoustic and haptic feedback on the complete closing of the system to form two sealed
  • the claimed system is designed so that the receiving device 2 can readily be used directly for preincubation. This saves time and material in the lab. In addition, there is a low risk that the sample removed will be contaminated or that the material removed can not be completely transferred, especially if only very little material is present.
  • the receiving device 2 forms in connection with the carrier 15 a closed space 4 in the lower or front part of the receiving device 2, so that the sample or the cells taken up can be protected against dehydration.
  • the lid adjoining the gripping element 13 can be fixed in two positions on the receiving device 2 in the form of the sealing surface 130, namely in a first, partially open position, in which the front locking device 134 on the Edge 233 'of the engagement device 233 rests, and in a second, fully closed position.
  • the first position for example in the incubation position or drying position or for centrifugation, the insertion opening 20 remains open so far that an incubation the sample is possible under air supply, the sample remains protected against external influences.
  • the open position it is also possible to centrifuge the sample in order to remove the cells from the cell receiving area 14 and there in particular from the foam material 16. Should it be necessary to store the sample in a dry place, the lid can also be left in this first position.
  • the handle member 13 For complete closure, the handle member 13 must be aligned such that the respective engagement means 233, 234 are aligned with the corresponding locking means 133, 134.
  • the locking means and the corresponding engagement means may be formed as threaded portions, so that the smear instrument 1 can be fixed in the receiving device 2 via a screwing movement.
  • the removal of the cells is optimized and a subsequent transfer of the removed cells to a plate with a medium in good quality possible.
  • the foam tip 16 is also suitable for the removal of cells from mucous membranes, such as the mouth, throat, abdomen or vagina, because a large-area removal of many cells without lesions in the patient is possible.
  • the system is thus suitable for taking, transporting, incubating and smearing cells for microorganism testing and for DNA and material collection for evidence collection.
  • the system is used in healthcare as well as in microbiology or forensic medicine. Due to the airtight completion of the smear instrument 1 within the receiving device 2, it is possible the smear instrument. 1 Store almost sterile in the unused state, which reduces the overall cost and increases the reliability of the results for the evaluation.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un système constitué d'un instrument de prélèvement (1) servant à prélever des cellules et d'un dispositif de logement (2) pour l'instrument de prélèvement (1). Cet instrument de prélèvement (1) comprend un support (10) pourvu d'une extrémité avant (11) et d'une extrémité arrière (12), une zone de prélèvement de cellules (14) se trouvant à l'extrémité avant (11) et un élément de prise (13) étant placé à l'extrémité arrière (12). Le dispositif de logement (2) destiné à l'instrument de prélèvement (1) présente une ouverture d'insertion (20) pour au moins la zone de prélèvement de cellules (14) et entoure cette zone de prélèvement de cellules (14), une extrémité arrière (15) de la zone de prélèvement de cellules (14), qui fait face à l'élément de prise (13), coopérant avec le dispositif de logement (2) de façon à former une chambre fermée (4), dans laquelle au moins une partie avant de la zone de prélèvement de cellules (14) est logée lorsque l'instrument de prélèvement (1) est complètement inséré dans le dispositif de logement (2).
PCT/DE2006/001084 2005-07-19 2006-06-23 Systeme constitue d'un instrument de prelevement servant a prelever des cellules ou a appliquer des preparations et dispositif de logement pour ledit instrument WO2007009414A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005034217.5 2005-07-19
DE102005034217A DE102005034217A1 (de) 2005-07-19 2005-07-19 System mit einem Abstrichinstrument für die Entnahme von Zellen oder das Auftragen von Präparaten sowie Aufnahmevorrichtung hierzu

Publications (1)

Publication Number Publication Date
WO2007009414A1 true WO2007009414A1 (fr) 2007-01-25

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DE (1) DE102005034217A1 (fr)
WO (1) WO2007009414A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013078014A1 (fr) * 2011-11-21 2013-05-30 In Hindsight Llc Dispositif de collecte, stockage et transport d'échantillons de cellules cytologiques
US9804063B2 (en) 2012-08-07 2017-10-31 Prionics Ag Sampling device for samples containing DNA in particular
US10456118B2 (en) 2010-11-24 2019-10-29 In Hindsight Llc Biological sample collection, storage, and transport system and method
WO2020160555A1 (fr) * 2019-02-01 2020-08-06 Mars, Incorporated Trousse, procédé et dispositif d'échantillonnage de microbiome oral

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010032012A1 (de) 2010-07-23 2012-01-26 Sms Siemag Aktiengesellschaft Lagerung von Walzenzapfen mittels Wälzlagern
DE102018009476B3 (de) 2018-03-03 2019-05-29 Georg Barth Excisionsskalpell
EP3756554A1 (fr) 2019-05-25 2020-12-30 Georg Barth Scalpel d'excérsion

Citations (5)

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Publication number Priority date Publication date Assignee Title
FR2103054A5 (fr) * 1970-07-20 1972-04-07 Curtis William
FR2412287A1 (fr) * 1977-12-21 1979-07-20 Oreal Conditionnement comportant un organe distributeur de produit de maquillage liquide
US4633886A (en) * 1985-05-02 1987-01-06 Bucaro Jr Russell J Device for home detection of cervical and vaginal cancer
EP1366715A1 (fr) * 2002-05-31 2003-12-03 Sentinel CH. S.r.L. Tube d'extraction pour la collection d'échantillons de féces
DE10326183A1 (de) * 2003-06-06 2004-12-23 Schlüter, Gert Vorrichtungen und Verfahren zur Gewinnung, Wiedergewinnung und Präparation von Abstrich-Zellmaterial

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2103054A5 (fr) * 1970-07-20 1972-04-07 Curtis William
FR2412287A1 (fr) * 1977-12-21 1979-07-20 Oreal Conditionnement comportant un organe distributeur de produit de maquillage liquide
US4633886A (en) * 1985-05-02 1987-01-06 Bucaro Jr Russell J Device for home detection of cervical and vaginal cancer
EP1366715A1 (fr) * 2002-05-31 2003-12-03 Sentinel CH. S.r.L. Tube d'extraction pour la collection d'échantillons de féces
DE10326183A1 (de) * 2003-06-06 2004-12-23 Schlüter, Gert Vorrichtungen und Verfahren zur Gewinnung, Wiedergewinnung und Präparation von Abstrich-Zellmaterial

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8961896B2 (en) 2010-11-24 2015-02-24 In Hindsight Llc Cytological cell sample collection, storage, and transport device
US9451935B2 (en) 2010-11-24 2016-09-27 In Hindsight Llc Biological sample collection, storage, and transport system and method
US10456118B2 (en) 2010-11-24 2019-10-29 In Hindsight Llc Biological sample collection, storage, and transport system and method
WO2013078014A1 (fr) * 2011-11-21 2013-05-30 In Hindsight Llc Dispositif de collecte, stockage et transport d'échantillons de cellules cytologiques
US9804063B2 (en) 2012-08-07 2017-10-31 Prionics Ag Sampling device for samples containing DNA in particular
WO2020160555A1 (fr) * 2019-02-01 2020-08-06 Mars, Incorporated Trousse, procédé et dispositif d'échantillonnage de microbiome oral
CN113710168A (zh) * 2019-02-01 2021-11-26 马斯公司 用于采样口腔微生物组的试剂盒、方法和装置

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Publication number Publication date
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