WO2007002885A3 - Compositions and methods for use of a sodium channel blocker - Google Patents

Compositions and methods for use of a sodium channel blocker Download PDF

Info

Publication number
WO2007002885A3
WO2007002885A3 PCT/US2006/025516 US2006025516W WO2007002885A3 WO 2007002885 A3 WO2007002885 A3 WO 2007002885A3 US 2006025516 W US2006025516 W US 2006025516W WO 2007002885 A3 WO2007002885 A3 WO 2007002885A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
sodium channel
compositions
channel blocker
urinary tract
Prior art date
Application number
PCT/US2006/025516
Other languages
French (fr)
Other versions
WO2007002885A2 (en
Inventor
Milton L Brown
William D Steers
Original Assignee
Univ Virginia
Milton L Brown
William D Steers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Virginia, Milton L Brown, William D Steers filed Critical Univ Virginia
Publication of WO2007002885A2 publication Critical patent/WO2007002885A2/en
Publication of WO2007002885A3 publication Critical patent/WO2007002885A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention encompasses compositions and methods of using sodium channel blockers to treat bladder and urinary tract diseases, disorder, and conditions such as overactive bladder, urge urinary incontinence, lower urinary tract symptoms due to benign prostatic hyperplasia.
PCT/US2006/025516 2005-06-29 2006-06-29 Compositions and methods for use of a sodium channel blocker WO2007002885A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69513405P 2005-06-29 2005-06-29
US60/695,134 2005-06-29
US73167705P 2005-10-31 2005-10-31
US60/731,677 2005-10-31

Publications (2)

Publication Number Publication Date
WO2007002885A2 WO2007002885A2 (en) 2007-01-04
WO2007002885A3 true WO2007002885A3 (en) 2009-04-09

Family

ID=37596073

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/025516 WO2007002885A2 (en) 2005-06-29 2006-06-29 Compositions and methods for use of a sodium channel blocker

Country Status (1)

Country Link
WO (1) WO2007002885A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9044482B2 (en) * 2012-08-15 2015-06-02 Asana Biosciences, Llc Use of aminoindane compounds in treating overactive bladder and interstitial cystitis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003088915A2 (en) * 2002-04-18 2003-10-30 University Of Virginia Patent Foundation Novel sodium channel blockers
US20040209960A1 (en) * 2003-01-30 2004-10-21 Dynogen Pharmaceuticals, Inc. Methods of treating lower urinary tract disorders using sodium channell modulators
EP1557166A1 (en) * 2004-01-21 2005-07-27 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003088915A2 (en) * 2002-04-18 2003-10-30 University Of Virginia Patent Foundation Novel sodium channel blockers
US20040209960A1 (en) * 2003-01-30 2004-10-21 Dynogen Pharmaceuticals, Inc. Methods of treating lower urinary tract disorders using sodium channell modulators
EP1557166A1 (en) * 2004-01-21 2005-07-27 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LENKOWSKI ET AL.: "Blocke of Human Nav 1.5 Sodium Channels by Novel Alpha-hydroxyphenylamide Analogues of Phenytoin", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 21, 2004, pages 635 - 644 *

Also Published As

Publication number Publication date
WO2007002885A2 (en) 2007-01-04

Similar Documents

Publication Publication Date Title
WO2008089236A3 (en) Compositions and methods for diagnosing, treating, and preventing prostate conditions
WO2006018743A3 (en) Herbal compositions for the prevention or treatment of urinary incontinence and overactive bladder
WO2007112073A3 (en) Methods for modulating bladder function
WO2007103448A3 (en) Rifaximin anti-rectal dysfunction preparation
WO2008060767A3 (en) Macrocyclic benzofused pyrimidine derivatives
WO2008033562A3 (en) Kinase inhibitor compounds
WO2010127099A3 (en) Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
WO2008021210A3 (en) Methods and compositions for the treatment of neurodegenerative disorders
EP1846005A4 (en) Kits and improved compositions for treating lower urinary tract
HK1123000A1 (en) Compositions and methods for the treatment and prevention of fibrotic, inflammatory and neovascularization conditions
WO2007092622A3 (en) Compositions and methods for treating bone
WO2006003388A8 (en) Compositions and methods for treating inflammatory disorders
WO2009052431A3 (en) Cd19 binding agents and uses thereof
WO2007112052A3 (en) Formulations and methods for vascular permeability-related diseases or conditions
WO2009026334A3 (en) Treatment with kallikrein inhibitors
WO2006091459A3 (en) Compositions and methods for treating vascular permeability
WO2007100617A3 (en) Imidazole-based compounds, compositions comprising them and methods of their use
WO2008063932A3 (en) Method for treating age-related macular degeneration
EP2083862A4 (en) Compositions and methods for treating ocular diseases and conditions
BRPI0506970B8 (en) alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders
WO2008149353A3 (en) Telomerase activating compounds and methods of use thereof
WO2009085270A3 (en) Use of inhibitors of c0nnexin43 for treatment of fibrotic conditions
WO2006009718A3 (en) Methods for treating or preventing erectile dysfunction or urinary incontinence
WO2008052139A3 (en) Ultra low dose doxepin and methods of using the same to treat sleep disorders
WO2007112121A3 (en) Tetracycline compounds and methods of treatment

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06774328

Country of ref document: EP

Kind code of ref document: A2