WO2006134430A3 - Apparatus for determining myocardial iron accumulation by analysing t2* magnetic resonance images - Google Patents

Apparatus for determining myocardial iron accumulation by analysing t2* magnetic resonance images Download PDF

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Publication number
WO2006134430A3
WO2006134430A3 PCT/IB2006/000880 IB2006000880W WO2006134430A3 WO 2006134430 A3 WO2006134430 A3 WO 2006134430A3 IB 2006000880 W IB2006000880 W IB 2006000880W WO 2006134430 A3 WO2006134430 A3 WO 2006134430A3
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WO
WIPO (PCT)
Prior art keywords
image
images
succession
echo times
magnetic resonance
Prior art date
Application number
PCT/IB2006/000880
Other languages
French (fr)
Other versions
WO2006134430A2 (en
Inventor
Luigi Landini
Vicenzo Positano
Alessia Pepe
Filomena Maria Santarelli
Massimo Lombardi
Antonio Benassi
Antonio L'abbate
Original Assignee
Cnr Consiglio Nazionale Delle Ricerche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cnr Consiglio Nazionale Delle Ricerche filed Critical Cnr Consiglio Nazionale Delle Ricerche
Publication of WO2006134430A2 publication Critical patent/WO2006134430A2/en
Publication of WO2006134430A3 publication Critical patent/WO2006134430A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/50—NMR imaging systems based on the determination of relaxation times, e.g. T1 measurement by IR sequences; T2 measurement by multiple-echo sequences
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5608—Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/565—Correction of image distortions, e.g. due to magnetic field inhomogeneities
    • G01R33/56509—Correction of image distortions, e.g. due to magnetic field inhomogeneities due to motion, displacement or flow, e.g. gradient moment nulling

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

An apparatus for analyzing of the distribution of iron content in determined anatomic regions, in particular in the heart, of thalassemic patients subject to many blood transfusion and for which martial accumulation should be monitored. In particular, the apparatus provides magnetic resonance means adapted to measure a succession of images (10), (20, 30), for example at the left ventricle of the myocardium, for different echo times (TE). More in detail, each succession of images (10), (20, 30) is taken at a determined height of the heart (50). For example, by scanning a plurality section of the left ventricle (51) of a patient at a plane α for different echo times (TE) a first succession of images (10) is obtained. Then by of suitable contour tracking means the image is defined so that the contours of the more relevant parts is highlighted. Each image is then computed by means of known algorithms in order to determine the values of the brightness (S) of its pixels. Then on each image (10) of the series an area of analysis (11) assimilated to a corona is defined between an outer contour (13) and an inner contour (14). The area (11) is then split into different portions, for example four equiangular sectors (15). For each field (15) of the image (10) it is possible to obtain on a diagram;a point of coordinates (S, TE). Repeating the step for different echo times it is possible then to obtain by interpolation a relative brightness decay curve.
PCT/IB2006/000880 2005-05-12 2006-04-13 Apparatus for determining myocardium martial accumulation by analysing magnetic resonance images WO2006134430A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITPI2005A000053 2005-05-12
IT000053A ITPI20050053A1 (en) 2005-05-12 2005-05-12 EQUIPMENT FOR THE EVALUATION OF THE MARTIAL ACCUMULATION IN MYCHARDIUM BY PROCESSING MAGNETIC RESONANCE IMAGES

Publications (2)

Publication Number Publication Date
WO2006134430A2 WO2006134430A2 (en) 2006-12-21
WO2006134430A3 true WO2006134430A3 (en) 2010-12-02

Family

ID=37532667

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/000880 WO2006134430A2 (en) 2005-05-12 2006-04-13 Apparatus for determining myocardium martial accumulation by analysing magnetic resonance images

Country Status (2)

Country Link
IT (1) ITPI20050053A1 (en)
WO (1) WO2006134430A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201121404D0 (en) * 2011-12-13 2012-01-25 Isis Innovation Diagnosis
GB201121406D0 (en) 2011-12-13 2012-01-25 Isis Innovation Systems and methods
GB201304728D0 (en) 2013-03-15 2013-05-01 Isis Innovation Medical imaging
GB201403877D0 (en) * 2014-03-05 2014-04-16 St Georges Hosp Medical School Apparatus and methods for detecting myocardial iron content using black-blood magnetic resonance data
KR102401111B1 (en) * 2020-01-29 2022-05-23 포항공과대학교 산학협력단 Apparatus and method for analyzing image of myocardial perfusion with magnetic resonance

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANDERSON LJ ET AL: "Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload", EUROPEAN HEART JOURNAL, vol. 22, 2001, pages 2171 - 2179, XP002602524 *
BROWN G ET AL: "Myocardial T2* relaxometry in secondary haemochromatosis: Impact of technical variations", PROCEEDINGS OF THE INTERNATIONAL SOCIETY FOR MAGNETIC RESONANCE IN MEDICINE, 13TH SCIENTIFIC MEETING AND EXHIBITION, MIAMI BEACH, FLORIDA, USA, 7-13 MAY 2005, 23 April 2005 (2005-04-23), pages 1668, XP002602523 *
CERQUEIRA M D ET AL: "STANDARDIZED MYOCARDIAL SEGMENTATION AND NOMENCLATURE FOR TOMOGRAPHIC IMAGING OF THE HEART A STATEMENT OF HEALTHCARE PROFESSIONALS FROM THE CARDIAC IMAGING COMMITTEE OF THE COUNCIL ON CLINICAL CARDIOLOGY OF THE AMERICAN HEART ASSOCIATION", CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, US LNKD- DOI:10.1161/HC0402.102975, vol. 105, no. 4, 29 January 2002 (2002-01-29), pages 539 - 542, XP001164153, ISSN: 0009-7322 *
NICOLAOU M: "CMR Tools - Thalassaemia Tools", 24 April 2005 (2005-04-24), XP002602525, Retrieved from the Internet <URL:http://web.archive.org/web/20060510204347/www.cmrtools.com/cmrTools/?m=8> [retrieved on 20100928] *
SLOMKA P J ET AL: "Patient Motion Correction for Multiplanar, Multi-Breath-Hold Cardiac Cine MR Imaging", JOURNAL OF MAGNETIC RESONANCE IMAGING, SOCIETY FOR MAGNETIC RESONANCE IMAGING, OAK BROOK, IL, US LNKD- DOI:10.1002/JMRI.20909, vol. 25, 1 January 2007 (2007-01-01), pages 965 - 973, XP002570163, ISSN: 1053-1807 *
WESTWOOD M ET AL: "A single breath-hold multiecho T2* cardiovascular magnetic resonance technique for diagnosis of myocardial iron overload", JOURNAL OF MAGNETIC RESONANCE IMAGING, vol. 18, 2003, pages 33 - 39, XP002602522 *

Also Published As

Publication number Publication date
WO2006134430A2 (en) 2006-12-21
ITPI20050053A1 (en) 2006-11-13

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