WO2006134374A3 - A method for production of l-ascorbic acid - Google Patents

A method for production of l-ascorbic acid Download PDF

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Publication number
WO2006134374A3
WO2006134374A3 PCT/GB2006/002203 GB2006002203W WO2006134374A3 WO 2006134374 A3 WO2006134374 A3 WO 2006134374A3 GB 2006002203 W GB2006002203 W GB 2006002203W WO 2006134374 A3 WO2006134374 A3 WO 2006134374A3
Authority
WO
WIPO (PCT)
Prior art keywords
ascorbic acid
production
organism
micro
polynucleotide
Prior art date
Application number
PCT/GB2006/002203
Other languages
French (fr)
Other versions
WO2006134374A2 (en
Inventor
Robert Douglas Hancock
Gary Davidson Hunter
Jane Shaw
Roberto Viola
Original Assignee
Scottish Crop Res Inst
Robert Douglas Hancock
Gary Davidson Hunter
Jane Shaw
Roberto Viola
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scottish Crop Res Inst, Robert Douglas Hancock, Gary Davidson Hunter, Jane Shaw, Roberto Viola filed Critical Scottish Crop Res Inst
Publication of WO2006134374A2 publication Critical patent/WO2006134374A2/en
Publication of WO2006134374A3 publication Critical patent/WO2006134374A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

There is provided a method for producing L-ascorbic acid (vitamin C) in which the enzymes tagatose epimerase and fucose isomerase are co-incubated with a micro-organism able to convert L-galactose to L- ascorbic acid. The micro-organism can be a yeast or a fungus. A recombinant polynucleotide comprising the sequence encoding for tagatose epimerase or fucose isomerase is also described, and the invention also includes a vector comprising such a polynucleotide and host cells transformed therewith.
PCT/GB2006/002203 2005-06-15 2006-06-15 A method for production of l-ascorbic acid WO2006134374A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0512150A GB0512150D0 (en) 2005-06-15 2005-06-15 Production of L-ascorbic acid
GB0512150.4 2005-06-15

Publications (2)

Publication Number Publication Date
WO2006134374A2 WO2006134374A2 (en) 2006-12-21
WO2006134374A3 true WO2006134374A3 (en) 2007-04-19

Family

ID=34855555

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/002203 WO2006134374A2 (en) 2005-06-15 2006-06-15 A method for production of l-ascorbic acid

Country Status (2)

Country Link
GB (1) GB0512150D0 (en)
WO (1) WO2006134374A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101203856B1 (en) * 2011-08-24 2012-11-21 씨제이제일제당 (주) D-psicose 3-epimerase variants improved thermostability and continuous production of D-psicose using the variants
GB2583417B (en) 2012-09-27 2021-03-31 Tate & Lyle Ingredients Americas Llc A protein
US9255120B2 (en) 2013-04-11 2016-02-09 California Institute Of Technology Conversion of glucose to sorbose
WO2018116266A1 (en) * 2016-12-23 2018-06-28 Petiva Private Ltd. D-psicose 3-epimerase mutant and uses thereof
US11028146B2 (en) * 2017-09-22 2021-06-08 Modern Meadow, Inc. Recombinant yeast strains

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004029267A1 (en) * 2002-09-27 2004-04-08 Dsm Ip Assets B.V. Process for producing l-ascorbic acid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004029267A1 (en) * 2002-09-27 2004-04-08 Dsm Ip Assets B.V. Process for producing l-ascorbic acid

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DATABASE EM_PRO [online] EMBL; 15 August 2001 (2001-08-15), HINKLE G. ET AL: "Agrobacterium tumefaciens str. C58 linear chromosome, section 14", XP002413357, retrieved from EBI accession no. AE008210 Database accession no. AE008210 *
DATABASE EM_PRO [online] EMBL; 6 July 1989 (1989-07-06), LU Z. ET AL: "Escherichia coli fucose operon", XP002413359, retrieved from EBI accession no. X15025 Database accession no. X15025 *
DATABASE UniProt [online] 1 June 2002 (2002-06-01), GOODNER B. ET AL: "D-tagatose 3-epimerase", XP002413358, retrieved from EBI accession no. QBU6Q7_AGRT5 Database accession no. QBU6Q7_AGRT5 *
DATABASE UniProt [online] 4 January 2005 (2005-01-04), LU Z. ET AL: "L-fucose isomerase", XP002413360, retrieved from EBI accession no. FUCI_ECOLI Database accession no. FUCI_ECOLI *
GOODNER B ET AL: "Genome Sequence of the Plant Pathogen and Biotechnology Agent Agrobacterium tumefaciens C58", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 294, 14 December 2001 (2001-12-14), pages 2323 - 2328, XP002981264, ISSN: 0036-8075 *
HANCOCK R D ET AL: "Biotechnological approaches for l-ascorbic acid production", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 20, no. 7, 1 July 2002 (2002-07-01), pages 299 - 305, XP004361398, ISSN: 0167-7799 *
KIM HYE-JUNG ET AL: "Characterization of an Agrobacterium tumefaciens D-psicose 3-epimerase that converts D-fructose to D-psicose", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 72, no. 2, February 2006 (2006-02-01), pages 981 - 985, XP002413340, ISSN: 0099-2240 *
LEANG KHIM ET AL: "A novel enzymatic approach to the massproduction of L-galactose from L-sorbose", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 97, no. 6, June 2004 (2004-06-01), pages 383 - 388, XP002413341, ISSN: 1389-1723 *

Also Published As

Publication number Publication date
WO2006134374A2 (en) 2006-12-21
GB0512150D0 (en) 2005-07-20

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