WO2006128455A3 - Compounds modifying apoptosis - Google Patents

Compounds modifying apoptosis Download PDF

Info

Publication number
WO2006128455A3
WO2006128455A3 PCT/DK2006/000280 DK2006000280W WO2006128455A3 WO 2006128455 A3 WO2006128455 A3 WO 2006128455A3 DK 2006000280 W DK2006000280 W DK 2006000280W WO 2006128455 A3 WO2006128455 A3 WO 2006128455A3
Authority
WO
WIPO (PCT)
Prior art keywords
apoptosis
compounds
compounds modifying
modifying apoptosis
inhibiting
Prior art date
Application number
PCT/DK2006/000280
Other languages
French (fr)
Other versions
WO2006128455A2 (en
Inventor
Ole Thastrup
Jens Norrild
Original Assignee
2Curex Aps
Ole Thastrup
Jens Norrild
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2005/000347 external-priority patent/WO2005116656A1/en
Application filed by 2Curex Aps, Ole Thastrup, Jens Norrild filed Critical 2Curex Aps
Priority to AU2006254538A priority Critical patent/AU2006254538A1/en
Priority to US11/914,994 priority patent/US8318717B2/en
Priority to EP06742429.1A priority patent/EP1888619B1/en
Publication of WO2006128455A2 publication Critical patent/WO2006128455A2/en
Publication of WO2006128455A3 publication Critical patent/WO2006128455A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala

Abstract

The present invention relates to compounds capable of inhibiting binding of the Smac protein to Inhibitors of apoptosis (IAPs). Such compounds are preferably capable of inhibiting IAP and thus may promote apoptosis or sensitize cells for apoptosis. The compounds may be used in the treatment of proliferative diseases, such as cancer.
PCT/DK2006/000280 2005-05-25 2006-05-23 Compounds modifying apoptosis WO2006128455A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2006254538A AU2006254538A1 (en) 2005-05-25 2006-05-23 Compounds modifying apoptosis
US11/914,994 US8318717B2 (en) 2005-05-25 2006-05-23 Compounds modifying apoptosis
EP06742429.1A EP1888619B1 (en) 2005-05-25 2006-05-23 Compounds modifying apoptosis

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DKPCT/DK2005/000347 2005-05-25
DKPA200500763 2005-05-25
DKPA200500763 2005-05-25
PCT/DK2005/000347 WO2005116656A1 (en) 2004-05-25 2005-05-25 Identification of compounds modifying a cellular response
DKPA200501663 2005-11-25
DKPA200501663 2005-11-25

Publications (2)

Publication Number Publication Date
WO2006128455A2 WO2006128455A2 (en) 2006-12-07
WO2006128455A3 true WO2006128455A3 (en) 2007-04-12

Family

ID=37482012

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2006/000280 WO2006128455A2 (en) 2005-05-25 2006-05-23 Compounds modifying apoptosis

Country Status (3)

Country Link
EP (1) EP1888619B1 (en)
AU (1) AU2006254538A1 (en)
WO (1) WO2006128455A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1773766B1 (en) 2004-07-15 2014-04-02 Tetralogic Pharmaceuticals Corporation Iap binding compounds
JP5198880B2 (en) 2005-02-25 2013-05-15 テトラロジック ファーマシューティカルズ コーポレーション Dimer IAP inhibitor
WO2006122408A1 (en) 2005-05-18 2006-11-23 Aegera Therapeutics Inc. Bir domain binding compounds
BRPI0617751A2 (en) 2005-10-25 2011-08-02 Aegera Therapeutics Inc iap bir domain binding compounds
TWI543988B (en) 2006-03-16 2016-08-01 科學製藥股份有限公司 Iap bir domain binding compounds
NZ572836A (en) 2006-05-16 2011-12-22 Pharmascience Inc Iap bir domain binding compounds
EP2049524A2 (en) 2006-07-24 2009-04-22 Tetralogic Pharmaceuticals Corporation Iap inhibitors
MX2009000824A (en) 2006-07-24 2009-02-04 Tetralogic Pharmaceuticals Cor Dimeric iap antagonists.
UY32099A (en) 2008-09-11 2010-04-30 Enanta Pharm Inc HEPATITIS C SERINA PROTEASAS MACROCYCLIC INHIBITORS
GB2472563B (en) * 2009-04-28 2013-02-27 Univ Leicester Method of preparing hairpin and cyclic polyamides
US8283372B2 (en) 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
UY32826A (en) 2009-08-04 2011-02-28 Takeda Pharmaceutical HETEROCYCLIC COMPOUNDS
EP2534170B1 (en) 2010-02-12 2017-04-19 Pharmascience Inc. Iap bir domain binding compounds
EP2658859A4 (en) 2010-12-30 2014-07-30 Enanta Pharm Inc Macrocyclic hepatitis c serine protease inhibitors
BR112013016480A2 (en) 2010-12-30 2016-09-20 Abbvie Inc phenanthridine macrocycle hepatitis c serine protease inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
KR20140011773A (en) * 2012-07-19 2014-01-29 한미약품 주식회사 Heterocyclic derivatives with dual inhibitory activity
WO2015103490A1 (en) 2014-01-03 2015-07-09 Abbvie, Inc. Solid antiviral dosage forms
WO2015109391A1 (en) 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
EP4093394A1 (en) 2020-01-20 2022-11-30 Astrazeneca AB Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0695757A2 (en) * 1994-08-01 1996-02-07 Arizona Board Of Regents Human cancer inhibitory peptide amides
WO2002096930A2 (en) * 2001-05-31 2002-12-05 The Trustees Of Princeton University Iap binding peptides and assays for identifying compounds that bind iap
WO2004005248A1 (en) * 2002-07-02 2004-01-15 Novartis Ag Peptide inhibitors of smac protein binding to inhibitor of apoptosis proteins (iap)
WO2004072105A2 (en) * 2003-02-12 2004-08-26 The Trustees Of Princeton University Iap-binding cargo molecules and peptidomimetics for use in diagnostic and therapeutic methods
WO2005116656A1 (en) * 2004-05-25 2005-12-08 2Curex Identification of compounds modifying a cellular response

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0695757A2 (en) * 1994-08-01 1996-02-07 Arizona Board Of Regents Human cancer inhibitory peptide amides
WO2002096930A2 (en) * 2001-05-31 2002-12-05 The Trustees Of Princeton University Iap binding peptides and assays for identifying compounds that bind iap
WO2004005248A1 (en) * 2002-07-02 2004-01-15 Novartis Ag Peptide inhibitors of smac protein binding to inhibitor of apoptosis proteins (iap)
WO2004072105A2 (en) * 2003-02-12 2004-08-26 The Trustees Of Princeton University Iap-binding cargo molecules and peptidomimetics for use in diagnostic and therapeutic methods
WO2005116656A1 (en) * 2004-05-25 2005-12-08 2Curex Identification of compounds modifying a cellular response

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BRIAN MCRAE ET AL.: "Studies on Reactivity of Human Leukocyte Elastase, Cathepsin G, and Procine Pancreatic Elastase toward Peptides Including Sequences Related to the Reactive Site of alpha1-Protease Inhibitor (alpha1-Antitrypsin)", BIOCHEMISTRY, vol. 19, 1980, pages 3973 - 3978, XP002415587 *
GROTH T ET AL: "PEG BASED RESINS FOR PROTEASE DRUG DISCOVERY SYNTHESIS, SCREENING AND ANALYSIS OF COMBINATORIAL ON-BEAD LIBRARIES", COMBINATORIAL CHEMISTRY AND HIGH THROUGHPUT SCREENING, HILVERSUM, NL, vol. 6, no. 7, November 2003 (2003-11-01), pages 589 - 610, XP008033922, ISSN: 1386-2073 *
KIPP R A ET AL: "Molecular targeting of inhibitor of apoptosis based on small molecule mimics of natural binding partners", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 41, no. 23, 2002, pages 7344 - 7349, XP002962287, ISSN: 0006-2960 *

Also Published As

Publication number Publication date
WO2006128455A2 (en) 2006-12-07
EP1888619B1 (en) 2013-04-17
AU2006254538A1 (en) 2006-12-07
EP1888619A2 (en) 2008-02-20

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