WO2006123354A3 - Oral pharmaceutical composition - Google Patents

Oral pharmaceutical composition Download PDF

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Publication number
WO2006123354A3
WO2006123354A3 PCT/IN2006/000042 IN2006000042W WO2006123354A3 WO 2006123354 A3 WO2006123354 A3 WO 2006123354A3 IN 2006000042 W IN2006000042 W IN 2006000042W WO 2006123354 A3 WO2006123354 A3 WO 2006123354A3
Authority
WO
WIPO (PCT)
Prior art keywords
weight
pharmaceutical composition
water
lipophilic
oral pharmaceutical
Prior art date
Application number
PCT/IN2006/000042
Other languages
French (fr)
Other versions
WO2006123354A2 (en
WO2006123354B1 (en
Inventor
Vijaya Kumar Velidi
Chancharusiri Apichai
Snehal Mukund Mehta
Wongpayak Pornchai
Madhav Pai Rajesh
Torane S Jyotsna
Ratilal Vavia Pradeep
Original Assignee
Mega Lifesciences Pvt Ltd
Vijaya Kumar Velidi
Chancharusiri Apichai
Snehal Mukund Mehta
Wongpayak Pornchai
Madhav Pai Rajesh
Torane S Jyotsna
Ratilal Vavia Pradeep
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mega Lifesciences Pvt Ltd, Vijaya Kumar Velidi, Chancharusiri Apichai, Snehal Mukund Mehta, Wongpayak Pornchai, Madhav Pai Rajesh, Torane S Jyotsna, Ratilal Vavia Pradeep filed Critical Mega Lifesciences Pvt Ltd
Priority to EP06780508A priority Critical patent/EP1848407A2/en
Publication of WO2006123354A2 publication Critical patent/WO2006123354A2/en
Publication of WO2006123354A3 publication Critical patent/WO2006123354A3/en
Publication of WO2006123354B1 publication Critical patent/WO2006123354B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins

Abstract

An oral pharmaceutical composition comprising about 0.1 to about 25% by weight of selective hydrophobic drug , about 0.5 to about 90% by weight of a lipophilic naturally occurring wetting agent, solubilizer and stabilizer comprising rice oil, about 0.5 to about 90% by weight of a lipophilic component, about 0.5 to about 90% by weight of a hydrophilic co-surfactant and about 0.5 to about 90% by weight of a surfactant, wherein the relative proportion of selective hydrophobic drug, hydrophilic components, lipophilic components and surfactants in said composition is such that upon dilution with water to a ratio of 1 part by weight of said composition to 100 parts by weight of water, an oil-in-water microemulsion having average particle size below 100 nm is spontaneously formed.
PCT/IN2006/000042 2005-02-02 2006-02-01 Oral pharmaceutical composition WO2006123354A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06780508A EP1848407A2 (en) 2005-02-02 2006-02-01 Oral pharmaceutical composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN104/MUM/2005 2005-02-02
IN104MU2005 2005-02-02

Publications (3)

Publication Number Publication Date
WO2006123354A2 WO2006123354A2 (en) 2006-11-23
WO2006123354A3 true WO2006123354A3 (en) 2007-02-15
WO2006123354B1 WO2006123354B1 (en) 2007-04-19

Family

ID=37106954

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2006/000042 WO2006123354A2 (en) 2005-02-02 2006-02-01 Oral pharmaceutical composition

Country Status (2)

Country Link
EP (1) EP1848407A2 (en)
WO (1) WO2006123354A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
CN101848702B (en) 2006-12-01 2013-07-17 安特里奥公司 Amphiphilic entity nanoparticles
TW200932240A (en) * 2007-10-25 2009-08-01 Astellas Pharma Inc Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
WO2009121069A2 (en) * 2008-03-28 2009-10-01 University Of Massachusetts Compositions and methods for the preparation of nanoemulsions
EP2308468A1 (en) 2009-10-08 2011-04-13 Novaliq GmbH Novel pharmaceutical composition comprising a macrolide immunosuppressant drug
CN110198703A (en) 2016-11-21 2019-09-03 艾里奥治疗公司 The transdermal delivery of big reagent

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6028067A (en) * 1997-12-05 2000-02-22 Chong Kun Dang Corp. Cyclosporin-containing microemulsion preconcentrate composition
US6616942B1 (en) * 1999-03-29 2003-09-09 Soft Gel Technologies, Inc. Coenzyme Q10 formulation and process methodology for soft gel capsules manufacturing
FR2837670A1 (en) * 2002-03-26 2003-10-03 Longechaud Veronique Fernandez Soft gelatin capsules filled with rice bran oil, useful for nutritional, cosmetic and therapeutic applications
US20030235595A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Oil-containing, orally administrable pharmaceutical composition for improved delivery of a therapeutic agent
US6761903B2 (en) * 1999-06-30 2004-07-13 Lipocine, Inc. Clear oil-containing pharmaceutical compositions containing a therapeutic agent
US20050008581A1 (en) * 2003-06-06 2005-01-13 Nbty, Inc. Methods and compositions that enhance bioavailability of coenzyme-Q10

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6028067A (en) * 1997-12-05 2000-02-22 Chong Kun Dang Corp. Cyclosporin-containing microemulsion preconcentrate composition
US6616942B1 (en) * 1999-03-29 2003-09-09 Soft Gel Technologies, Inc. Coenzyme Q10 formulation and process methodology for soft gel capsules manufacturing
US20030235595A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Oil-containing, orally administrable pharmaceutical composition for improved delivery of a therapeutic agent
US6761903B2 (en) * 1999-06-30 2004-07-13 Lipocine, Inc. Clear oil-containing pharmaceutical compositions containing a therapeutic agent
FR2837670A1 (en) * 2002-03-26 2003-10-03 Longechaud Veronique Fernandez Soft gelatin capsules filled with rice bran oil, useful for nutritional, cosmetic and therapeutic applications
US20050008581A1 (en) * 2003-06-06 2005-01-13 Nbty, Inc. Methods and compositions that enhance bioavailability of coenzyme-Q10

Also Published As

Publication number Publication date
WO2006123354A2 (en) 2006-11-23
WO2006123354B1 (en) 2007-04-19
EP1848407A2 (en) 2007-10-31

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