WO2006120406A3 - Gene over-expression in d. discoideum for identifying farnesyl diphosphate synthase antagonists useful for treating bone diseases - Google Patents

Gene over-expression in d. discoideum for identifying farnesyl diphosphate synthase antagonists useful for treating bone diseases Download PDF

Info

Publication number
WO2006120406A3
WO2006120406A3 PCT/GB2006/001658 GB2006001658W WO2006120406A3 WO 2006120406 A3 WO2006120406 A3 WO 2006120406A3 GB 2006001658 W GB2006001658 W GB 2006001658W WO 2006120406 A3 WO2006120406 A3 WO 2006120406A3
Authority
WO
WIPO (PCT)
Prior art keywords
identifying
discoideum
expression
bone diseases
diphosphate synthase
Prior art date
Application number
PCT/GB2006/001658
Other languages
French (fr)
Other versions
WO2006120406A2 (en
Inventor
Jeffrey Graham Williams
Original Assignee
Univ Dundee
Jeffrey Graham Williams
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Dundee, Jeffrey Graham Williams filed Critical Univ Dundee
Publication of WO2006120406A2 publication Critical patent/WO2006120406A2/en
Publication of WO2006120406A3 publication Critical patent/WO2006120406A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/44—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from protozoa
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/9116—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • G01N2333/91165—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5) general (2.5.1)
    • G01N2333/91171—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5) general (2.5.1) with definite EC number (2.5.1.-)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to drug screening assays. The present invention also relates to methods of identifying putative drug target genes/proteins, as well as methods of testing the efficacy of test drug candidates.
PCT/GB2006/001658 2005-05-07 2006-05-08 Gene over-expression in d. discoideum for identifying farnesyl diphosphate synthase antagonists useful for treating bone diseases WO2006120406A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0509340A GB0509340D0 (en) 2005-05-07 2005-05-07 Gene over-expression
GB0509340.6 2005-05-07

Publications (2)

Publication Number Publication Date
WO2006120406A2 WO2006120406A2 (en) 2006-11-16
WO2006120406A3 true WO2006120406A3 (en) 2007-05-10

Family

ID=34685234

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/001658 WO2006120406A2 (en) 2005-05-07 2006-05-08 Gene over-expression in d. discoideum for identifying farnesyl diphosphate synthase antagonists useful for treating bone diseases

Country Status (2)

Country Link
GB (1) GB0509340D0 (en)
WO (1) WO2006120406A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1184462A2 (en) * 2000-09-01 2002-03-06 SmithKline Beecham Corporation Identification of targets of antimicrobial compounds
US20030108872A1 (en) * 2000-08-23 2003-06-12 Mark Sulavik Genomics-assisted rapid identification of targets

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030108872A1 (en) * 2000-08-23 2003-06-12 Mark Sulavik Genomics-assisted rapid identification of targets
EP1184462A2 (en) * 2000-09-01 2002-03-06 SmithKline Beecham Corporation Identification of targets of antimicrobial compounds

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GROVE J E ET AL: "THE INTRACELLULAR TARGET FOR THE ANTIRESOPRTIVE AMINOBISPHOSPHONATE DRUGS IN DICTYOSTELIUM DISCOIDEUM IS THE ENZYME FARNESYL DIPHOSPHATE SYNTHASE", JOURNAL OF BONE AND MINERAL RESEARCH, NEW YORK, NY, US, vol. 15, no. 5, May 2000 (2000-05-01), pages 971 - 981, XP008034423, ISSN: 0884-0431 *
LI X ET AL: "Multicopy Suppressors for Novel Antibacterial Compounds Reveal Targets and Drug Efflux Susceptibility", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 11, no. 10, October 2004 (2004-10-01), pages 1423 - 1430, XP004601876, ISSN: 1074-5521 *
SUGDEN C J ET AL: "Engineered gene over-expression as a method of drug target identification", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 334, no. 2, 26 August 2005 (2005-08-26), pages 555 - 560, XP004979487, ISSN: 0006-291X *

Also Published As

Publication number Publication date
GB0509340D0 (en) 2005-06-15
WO2006120406A2 (en) 2006-11-16

Similar Documents

Publication Publication Date Title
WO2009067546A3 (en) Lung cancer markers and uses thereof
WO2007034221A3 (en) Non small cell lung cancer therapy prognosis and target
WO2006113245A3 (en) Methods for measuring glycan levels of proteins
WO2008036691A3 (en) Biomarkers for prostate cancer and methods using the same
EP1994142A4 (en) Methods and compositions for the rapid isolation of small rna molecules
WO2005093429A3 (en) Method for the detection of intracellular parameters with luminescent protein probes for the screening of molecules capable of altering said parameters
WO2008054600A3 (en) Compositions and methods for biodetection by nucleic acid-templated chemistry
WO2011100541A3 (en) Compositions and methods for the detection of small rnas
WO2010045318A3 (en) Gene and gene expressed protein targets depicting biomarker patterns and signature sets by tumor type
WO2009086215A3 (en) Pathway analysis of cell culture phenotypes and uses thereof
WO2008148072A3 (en) Disease-associated genetic variations and methods for obtaining and using same
TWI317811B (en)
UA94582C2 (en) Genetic modification mon89788 of soybean and methods for its determination
WO2009022907A3 (en) A method for identifying, expanding, and removing adult stem cells and cancer stem cells
WO2007136736A3 (en) Methods for nucleic acid sorting and synthesis
WO2012024255A3 (en) Camkk-beta as a target for treating cancer
WO2009113814A3 (en) Protein marker for early diagnosis of liver cancer
WO2008054514A3 (en) Differential expression profiling analysis of cell culture phenotypes and the uses thereof
EP2374884A3 (en) Human miRNAs isolated from mesenchymal stem cells
WO2007118242A3 (en) Identification of a constitutively resistant cancer stem cell
WO2011087709A3 (en) Eml4-alk translocations in lung cancer
EP2075341A4 (en) Method for study, determination or evaluation by gene expression analysis
WO2011036666A3 (en) Systems and methods for measuring translation of target proteins in cells
WO2005067648A3 (en) Multiplex spatial profiling of gene expression
WO2007120955A3 (en) Genes affecting human memory performance

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

NENP Non-entry into the national phase

Ref country code: RU

WWW Wipo information: withdrawn in national office

Country of ref document: RU

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 06727027

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 06727027

Country of ref document: EP

Kind code of ref document: A2